Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage
J Nanobiotechnology. 2024 May 9;22(1):233. doi: 10.1186/s12951-024-02503-7. ABSTRACT BACKGROUND: Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients’ quality of life and social functioning. Currently, anti-inflammatory drugs […]
ADVANCES IN ALZHEIMER’S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION
Neurochem Int. 2024 May 7:105761. doi: 10.1016/j.neuint.2024.105761. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) remains one of the most formidable neurological disorders, affecting millions globally. This review provides a holistic overview of the therapeutic strategies, both conventional and novel, aimed at mitigating the impact of AD. Initially, we delve into the conventional approach, emphasizing […]
Inhibiting the SARM1-NAD+ axis reduces oxidative stress-induced damage to retinal and nerve cells
Int Immunopharmacol. 2024 May 8;134:112193. doi: 10.1016/j.intimp.2024.112193. Online ahead of print. ABSTRACT Retinal neurodegenerative diseases are a category of refractory blinding eye conditions closely associated with oxidative stress induced by mitochondrial dysfunction in retinal cells. SARM1, a core driver molecule leading to axonal degeneration, possesses NAD+ enzyme (NADase) activity. However, the role of the SARM1-NAD+ […]
Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca2+-dependent AMPK/mTOR pathway
Int J Ophthalmol. 2024 Mar 18;17(3):420-434. doi: 10.18240/ijo.2024.03.03. eCollection 2024. ABSTRACT AIM: To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells (LECs) under hyperosmotic stress. METHODS: LECs were treated with hyperosmotic stress at the concentration of 270, 300, 400, 500, or 600 mOsm for 6, 12, 18, 24h in vitro. […]
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
Cell Biosci. 2024 May 8;14(1):58. doi: 10.1186/s13578-024-01242-4. ABSTRACT The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of the innate immune system, is involved in the development of several diseases. Ectopic DNA-induced inflammatory responses are involved in several pathological processes. Repeated damage to tissues and metabolic organelles […]
Mitochondrial DNA-Associated Leigh Syndrome Spectrum
2003 Oct 30 [updated 2024 May 9]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: Mitochondrial DNA-associated Leigh syndrome spectrum (mtDNA-LSS) is part of a continuum of progressive neurodegenerative disorders caused by abnormalities […]
Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced-Pulmonary Fibrosis
Adv Sci (Weinh). 2024 May 7:e2401394. doi: 10.1002/advs.202401394. Online ahead of print. ABSTRACT Currently, the typical combination therapy of programmed death ligand-1 (PD-L1) antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in clinical due to lessened DNA damage and acquired immune tolerance via the upregulation of some other immune checkpoint inhibitors. Apart from […]
Galactose-Replacement Unmasks the Biochemical Consequences of the G11778A Mitochondrial DNA Mutation of LHON in Patient-Derived Fibroblasts
Exp Cell Res. 2024 May 4:114075. doi: 10.1016/j.yexcr.2024.114075. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a visual impairment associated with mutations of mitochondrial genes encoding elements of the electron transport chain. While much is known about the genetics of LHON, the cellular pathophysiology leading to retinal ganglion cell degeneration and subsequent […]
Mitochondria-Targeted Nanoadjuvants Induced Multi-Functional Immune-Microenvironment Remodeling to Sensitize Tumor Radio-Immunotherapy
Adv Sci (Weinh). 2024 May 5:e2400297. doi: 10.1002/advs.202400297. Online ahead of print. ABSTRACT It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand-1 (PD-L1) overexpression and transforming growth factor-β (TGF-β) excessive secretion would accelerate […]
Mitochondrial retinopathies and optic neuropathies: the impact of retinal imaging on modern understanding of pathogenesis, diagnosis, and management
Prog Retin Eye Res. 2024 May 2:101264. doi: 10.1016/j.preteyeres.2024.101264. Online ahead of print. ABSTRACT Advancements in ocular imaging have significantly broadened our comprehension of mitochondrial retinopathies and optic neuropathies by examining the structural and pathological aspects of the retina and optic nerve in these conditions. This article aims to review the prominent imaging characteristics associated […]