The antioxidant effect of tetrahedral framework nucleic acid-based delivery of small activating RNA targeting DJ-1 on retinal oxidative stress injury
Cell Prolif. 2024 Apr 9:e13635. doi: 10.1111/cpr.13635. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the world’s leading causes of blindness. The retinal pigment epithelium (RPE) and vascular endothelial cell exposed to oxidative stress is the major cause of AMD and DR. DJ-1, an important endogenous antioxidant, its overexpression […]
Selective microRNA expression of exosomes from retinal pigment epithelial cells by oxidative stress
Vision Res. 2024 Apr 8;220:108388. doi: 10.1016/j.visres.2024.108388. Online ahead of print. ABSTRACT The function of exosomal miRNAs (miRs) in retinal degeneration is largely unclear. We were aimed to investigate the functions of exosomes as well as their miRs derived from retinal pigment epithelial (RPE) cells following exposure to oxidative stress (OS). After the OS by […]
Poor visual prognosis of Asian patients with 3460 mitochondrial DNA mutation in Leber’s hereditary optic neuropathy
Can J Ophthalmol. 2024 Apr 6:S0008-4182(24)00095-4. doi: 10.1016/j.jcjo.2024.03.013. Online ahead of print. ABSTRACT BACKGROUND: Among the 3 primary mutations of Leber’s hereditary optic neuropathy (LHON), the incidence of LHON with a mutation at nucleotide position 3460 is the lowest in Asians. Therefore, information about the clinical manifestations of LHON mutations in Asians with the 3460 […]
Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases
Front Med (Lausanne). 2024 Mar 22;11:1353624. doi: 10.3389/fmed.2024.1353624. eCollection 2024. ABSTRACT In the field of eye health, the profound impact of exercise and physical activity on various ocular diseases has become a focal point of attention. This review summarizes and elucidates the positive effects of exercise and physical activities on common ocular diseases, including dry […]
Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy
CNS Neurosci Ther. 2024 Apr;30(4):e14707. doi: 10.1111/cns.14707. ABSTRACT AIMS: Mitochondria-associated endoplasmic reticulum membranes (MAMs) serve as a crucial bridge connecting the endoplasmic reticulum (ER) and mitochondria within cells. Vesicle-associated membrane protein-associated protein B (VAPB) and protein tyrosine phosphatase interacting protein 51 (PTPIP51) are responsible for the formation and stability of MAMs, which have been implicated […]
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 4:167157. doi: 10.1016/j.bbadis.2024.167157. Online ahead of print. ABSTRACT Statins are the first line of choice for the treatment for atherosclerosis, but their use can cause myotoxicity, a common side effect that may require dosage reduction or discontinuation. The exact mechanism of statin-induced myotoxicity is unknown. Previous research […]
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print. ABSTRACT Non-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and […]
Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Acta Neuropathol Commun. 2024 Apr 5;12(1):53. doi: 10.1186/s40478-024-01768-1. NO ABSTRACT PMID:38581047 | DOI:10.1186/s40478-024-01768-1
PGC-1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age-related macular degeneration
J Cell Mol Med. 2024 Apr;28(8):e18051. doi: 10.1111/jcmm.18051. ABSTRACT We previously showed that mice with knockout in the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) gene encoding the PGC-1α protein, and nuclear factor erythroid 2 like 2 (NFE2L2) gene, exhibited some features of the age-related macular degeneration (AMD) phenotype. To further explore the mechanism behind […]
Secondary follicles enable efficient germline mtDNA base editing at hard-to-edit site
Mol Ther Nucleic Acids. 2024 Mar 11;35(2):102170. doi: 10.1016/j.omtn.2024.102170. eCollection 2024 Jun 11. ABSTRACT Efficient germline mtDNA editing is required to construct disease-related animal models and future gene therapy. Recently, the DddA-derived cytosine base editors (DdCBEs) have made mitochondrial genome (mtDNA) precise editing possible. However, there still exist challenges for editing some mtDNA sites in […]