Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Acta Neuropathol Commun. 2024 May 21;12(1):79. doi: 10.1186/s40478-024-01782-3. ABSTRACT Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death. The retina is often affected in common neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Studies have demonstrated that the retina in patients with […]
Human Conjunctival Transcriptome in Acanthamoeba Keratitis: An Exploratory Study
Cornea. 2024 May 21. doi: 10.1097/ICO.0000000000003545. Online ahead of print. ABSTRACT PURPOSE: The purpose of this study was to identify conjunctival transcriptome differences in patients with Acanthamoeba keratitis compared with keratitis with no known associated pathogen. METHODS: The host conjunctival transcriptome of 9 patients with Acanthamoeba keratitis (AK) is compared with the host conjunctival transcriptome […]
Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression
Discov Oncol. 2024 May 21;15(1):178. doi: 10.1007/s12672-024-01045-6. ABSTRACT OBJECTIVE: Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional Chinese medicine to intervene and treat melanoma, we turned our attention to celastrol. […]
l-Serine Protects Murine Retinal Ganglion Cells from Oxidative Stress via Modulation of Mitochondrial Dysfunction
Curr Eye Res. 2024 May 21:1-9. doi: 10.1080/02713683.2024.2355661. Online ahead of print. ABSTRACT PURPOSE: This study aimed to investigate the effects of l-serine on mitochondrial dysfunction in retinal ganglion cells after exposure to H2O2-induced oxidative stress. METHODS: Retinal ganglion cells obtained from C57BL6 mice (postnatal days 1-4) were purified and cultured. A cell viability assay […]
Impaired mitochondrial morphological plasticity and failure of mitophagy associated with the G11778A mutation of LHON
Biochem Biophys Res Commun. 2024 May 14;721:150119. doi: 10.1016/j.bbrc.2024.150119. Online ahead of print. ABSTRACT Mitochondrial dynamics were examined in human dermal fibroblasts biopsied from a confirmed Leber’s Hereditary Optic Neuropathy (LHON) patient with a homoplasmic G11778A mutation of the mitochondrial genome. Expression of the G11778A mutation did not impart any discernible difference in mitochondrial network […]
Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting
ACS Appl Mater Interfaces. 2024 May 20. doi: 10.1021/acsami.4c01382. Online ahead of print. ABSTRACT Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and the regulation of TPP linkage modes […]
Histopathological findings of anterior lens capsule in pediatric cataract
Indian J Ophthalmol. 2024 May 20. doi: 10.4103/IJO.IJO_2957_23. Online ahead of print. ABSTRACT PURPOSE: To investigate the histopathological findings of the anterior lens capsule in pediatric patients who had surgery for cataracts. METHODS: This study is a prospective interventional study. Anterior capsule tissue samples that were obtained by the anterior capsulotomy method during phacoemulsification surgery […]
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis
Inflammation. 2024 May 18. doi: 10.1007/s10753-024-02053-y. Online ahead of print. ABSTRACT Uveitis is an autoimmune eye disease that can be involved in the entire body and is one of the leading causes of blindness. Therefore, comprehending the mechanisms underlying the development and regulation of ocular immune responses in uveitis is crucial for designing effective therapeutic […]
Alzheimer’s Disease Pathophysiology in the Retina
Prog Retin Eye Res. 2024 May 15:101273. doi: 10.1016/j.preteyeres.2024.101273. Online ahead of print. ABSTRACT The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of Alzheimer’s disease (AD). Studies have identified the pathological hallmarks of AD, including amyloid β-protein (Aβ) deposits and abnormal tau protein isoforms, in the retinas of AD patients […]
Co-occurrence of glial fibrillary acidic protein astrocytopathy in a patient with Leber’s hereditary optic neuropathy due to DNAJC30 mutations
Eur J Neurol. 2024 May 17:e16344. doi: 10.1111/ene.16344. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss, and rarely associated with extraocular manifestations including multiple sclerosis-like lesions. The association of LHON and neuromyelitis optica spectrum disorders has rarely been reported. Here is reported a case of […]