p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model
Neural Regen Res. 2024 Oct 1;19(10):2299-2309. doi: 10.4103/1673-5374.391193. Epub 2023 Dec 21. ABSTRACT JOURNAL/nrgr/04.03/01300535-202410000-00031/figure1/v/2024-02-06T055622Z/r/image-tiff Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogen-activated protein kinase (MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its downstream targets, such as p53, have […]
Acetazolamide Challenge Changes Outer Retina Bioenergy-Linked and Anatomical OCT Biomarkers Depending on Mouse Strain
Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):21. doi: 10.1167/iovs.65.3.21. ABSTRACT PURPOSE: The purpose of this study was to test the hypothesis that optical coherence tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an acetazolamide (ACZ) provocation. METHODS: C57BL/6J mice (B6J, a strain with relatively inefficient mitochondria) and 129S6/ev mice (S6, a strain with relatively […]
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12153. Online ahead of print. ABSTRACT Oxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative damage and NLRP3 inflammasome play important roles in neuropathic pain development. Here, neuropathic pain mouse model was constructed […]
Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant
Brain. 2024 Mar 13:awae057. doi: 10.1093/brain/awae057. Online ahead of print. ABSTRACT Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterised by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA (mtDNA) genes and more than 100 nuclear genes, most often […]
Chlorine-Induced Toxicity on Murine Cornea: Exploring the Potential Therapeutic Role of Antioxidants
Cells. 2024 Mar 5;13(5):458. doi: 10.3390/cells13050458. ABSTRACT Chlorine (Cl2) exposure poses a significant risk to ocular health, with the cornea being particularly susceptible to its corrosive effects. Antioxidants, known for their ability to neutralize reactive oxygen species (ROS) and alleviate oxidative stress, were explored as potential therapeutic agents to counteract chlorine-induced damage. In vitro experiments […]
Peripapillary retinal nerve fibre layer thinning, perfusion changes and optic neuropathy in carriers of Leber hereditary optic neuropathy-associated mitochondrial variants
BMJ Open Ophthalmol. 2024 Mar 11;9(1):e001295. doi: 10.1136/bmjophth-2023-001295. ABSTRACT BACKGROUND: We investigated Leber hereditary optic neuropathy (LHON) families for variation in peripapillary retinal nerve fibre layer thickness and perfusion, and associated optic nerve dysfunction. METHOD: A group of LHON-affected patients (n=12) and their asymptomatic maternal relatives (n=16) underwent examination including visual acuity (VA), visual-evoked-potential and […]
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
Exp Eye Res. 2024 Mar 9:109860. doi: 10.1016/j.exer.2024.109860. Online ahead of print. ABSTRACT Recent studies have highlighted that retinal neurodegeneration precedes microvascular changes in diabetic retinopathy (DR), but the specific mechanisms remain unclear. Given the pivotal role of dysfunctional mitochondria and oxidative stress in early DR, our objective was to observe mitochondria-related alterations in the […]
A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder
Genet Med. 2024 Mar 7:101119. doi: 10.1016/j.gim.2024.101119. Online ahead of print. ABSTRACT PURPOSE: FEM1B acts as a substrate recognition subunit for ubiquitin ligase complexes belonging to the CRL2 E3 family. Several biological functions have been proposed for FEM1B, including a structurally resolved function as a sensor for redox cell status by controlling mitochondrial activity, but […]
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
EPMA J. 2024 Feb 27;15(1):1-23. doi: 10.1007/s13167-024-00356-6. eCollection 2024 Mar. ABSTRACT Worldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The estimated global economic burden by stroke is over US$891 billion per year. Within three decades (1990-2019), the incidence increased by 70%, deaths by 43%, […]
Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration
BMJ Open Ophthalmol. 2024 Mar 9;9(1):e001622. doi: 10.1136/bmjophth-2023-001622. ABSTRACT PURPOSE: Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage. METHODS: Post hoc analysis of a cross-sectional study. 165 […]