Trilliumosides K and L, two novel steroidal saponins from rhizomes of Trillium govanianum, as potent anti-cancer agents targeting apoptosis in the A-549 cancer cell line
Front Chem. 2023 Dec 22;11:1306271. doi: 10.3389/fchem.2023.1306271. eCollection 2023. ABSTRACT Two novel steroidal saponins, trilliumosides K (1) and L (2), were isolated from the rhizomes of Trillium govanianum led by bioactivity-guided phytochemical investigation along with seven known compounds: govanoside D (3), protodioscin (4), borassoside E (5), 20-hydroxyecdysone (6), 5,20-hydroxyecdysone (7), govanic acid (8), and diosgenin […]
Subacute-onset cataract in a 29-year-old man with mitochondrial encephalomyopathy: A case report
Clin Case Rep. 2024 Jan 4;12(1):e8417. doi: 10.1002/ccr3.8417. eCollection 2024 Jan. ABSTRACT This case report aims to emphasize that subacute occurrence of nuclear cataract might be one of the underestimated manifestations of mitochondrial encephalomyopathy, thus periodical ophthalmologic examinations are recommended. PMID:38188847 | PMC:PMC10766551 | DOI:10.1002/ccr3.8417
UCP2-SIRT3 Signaling Relieved Hyperglycemia-Induced Oxidative Stress and Senescence in Diabetic Retinopathy
Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):14. doi: 10.1167/iovs.65.1.14. ABSTRACT PURPOSE: Diabetic retinopathy (DR) is one of the most common reasons for blindness. uncoupling protein 2 (UCP2), an uncoupling protein located in mitochondria, has been reported to be related to metabolic and vascular diseases. This research aimed to illustrate the function and mechanism of UCP2 […]
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage
Heliyon. 2023 Dec 11;10(1):e23426. doi: 10.1016/j.heliyon.2023.e23426. eCollection 2024 Jan 15. ABSTRACT Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for a range of diseases, including ischemic stroke, myocardial infarction, and trauma. Following the restoration of blood flow post-tissue ischemia, oxidative stress can lead to various forms of cell death, including necrosis, apoptosis, autophagy, and necroptosis. […]
Global scientific trends in healthy aging in the early 21st century: A data-driven scientometric and visualized analysis
Heliyon. 2023 Dec 9;10(1):e23405. doi: 10.1016/j.heliyon.2023.e23405. eCollection 2024 Jan 15. ABSTRACT BACKGROUND: According to the World Health Organization (WHO), healthy aging is the process of developing and maintaining the functional capacity for health in old age. A rapidly growing number of research studies on healthy aging have been conducted worldwide. The purpose of this research […]
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage
Cell Commun Signal. 2024 Jan 2;22(1):3. doi: 10.1186/s12964-023-01362-3. ABSTRACT Primary subarachnoid hemorrhage (SAH) is a type of acute stroke, accounting for approximately 10% of cases, with high disability and mortality rate. Early brain injury (EBI) is a critical factor in determining SAH mortality; however, there are no effective treatment interventions for EBI. Based on our […]
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn2+ homeostasis
Free Radic Biol Med. 2023 Dec 27;212:220-233. doi: 10.1016/j.freeradbiomed.2023.12.028. Online ahead of print. ABSTRACT Nucleus pulposus (NP) cell function-loss is one main contributor during intervertebral disc degeneration (IDD) progression. Both mitochondria and endoplasmic reticulum (ER) play vital roles in sustaining NP cell homeostasis, while the precise function of ER-mitochondria tethering and cross talk in IDD […]
Role of heat shock protein 70 in silibinin-induced apoptosis in bladder cancer
J Cancer. 2024 Jan 1;15(1):79-89. doi: 10.7150/jca.88668. eCollection 2024. ABSTRACT Hsp70 (heat shock protein 70) plays critical roles in cancer cell proliferation and apoptosis. Recently, accumulating evidences have demonstrated the cancer promoting effects of Hsp70 in bladder cancer. The development of novel therapeutic approaches targeting Hsp70 thus received great attention from researchers. In this study, […]
Fat oxidation rates and cardiorespiratory responses during exercise in different subject populations with post-acute sequelae of SARS-CoV-2 infection: a comparison with normative percentile values
Front Physiol. 2023 Dec 8;14:1310319. doi: 10.3389/fphys.2023.1310319. eCollection 2023. ABSTRACT Introduction: Post-acute sequelae of SARS-CoV-2 infection (PASC) presents a spectrum of symptoms following acute COVID-19, with exercise intolerance being a prevalent manifestation likely linked to disrupted oxygen metabolism and mitochondrial function. This study aims to assess maximal fat oxidation (MFO) and exercise intensity at MFO […]
Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism
J Extracell Vesicles. 2024 Jan;13(1):e12401. doi: 10.1002/jev2.12401. ABSTRACT Retinal degeneration (RD), a group of diseases leading to irreversible vision loss, is characterised by retinal pigment epithelium (RPE) or retinal neuron damage and loss. With fewer risks of immune rejection and tumorigenesis, stem cell-secreted extracellular vesicles (EVs) offer a new cell-free therapeutic paradigm for RD, which […]