Near infrared/ red light therapy a potential countermeasure for mitochondrial dysfunction in spaceflight associated neuro-ocular syndrome (SANS)
Eye (Lond). 2024 May 3. doi: 10.1038/s41433-024-03091-4. Online ahead of print. NO ABSTRACT PMID:38702514 | DOI:10.1038/s41433-024-03091-4
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
World J Stem Cells. 2024 Apr 26;16(4):444-458. doi: 10.4252/wjsc.v16.i4.444. ABSTRACT BACKGROUND: Leukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional therapies. Gossypol acetic acid (GAA), which is extracted from […]
Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print. ABSTRACT Extralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred […]
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print. ABSTRACT Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of […]
Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology
Ophthalmol Sci. 2024 Mar 5;4(4):100504. doi: 10.1016/j.xops.2024.100504. eCollection 2024 Jul-Aug. ABSTRACT PURPOSE: Genome-wide association studies have recently uncovered many loci associated with variation in intraocular pressure (IOP). Artificial intelligence (AI) can be used to interrogate the effect of specific genetic knockouts on the morphology of trabecular meshwork cells (TMCs) and thus, IOP regulation. DESIGN: Experimental […]
Targeted Metabolomics Highlights Dramatic Antioxidant Depletion, Increased Oxidative/Nitrosative Stress and Altered Purine and Pyrimidine Concentrations in Serum of Primary Myelofibrosis Patients
Antioxidants (Basel). 2024 Apr 19;13(4):490. doi: 10.3390/antiox13040490. ABSTRACT To date, little is known concerning the circulating levels of biochemically relevant metabolites (antioxidants, oxidative/nitrosative stress biomarkers, purines, and pyrimidines) in patients with primary myelofibrosis (PMF), a rare form of myeloproliferative tumor causing a dramatic decrease in erythropoiesis and angiogenesis. In this study, using a targeted metabolomic […]
REGULATORY ROLES OF microRNAs IN MODULATING MITOCHONDRIAL DYNAMICS, AMYLOID BETA FIBRILLATION, MICROGLIAL ACTIVATION, AND CHOLINERGIC SIGNALING: IMPLICATIONS FOR ALZHEIMER’S DISEASE PATHOGENESIS
Neurosci Biobehav Rev. 2024 Apr 24:105685. doi: 10.1016/j.neubiorev.2024.105685. Online ahead of print. ABSTRACT Alzheimer’s Disease (AD) remains a formidable challenge due to its complex pathology, notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling. This study delves into the underexplored realm of miRNAs’ impact on mitochondrial dynamics and their interplay with amyloid-beta (Aβ) aggregation and […]
CRISPR-Cas9-mediated deletion of carbonic anhydrase 2 in the ciliary body to treat glaucoma
Cell Rep Med. 2024 Apr 21:101524. doi: 10.1016/j.xcrm.2024.101524. Online ahead of print. ABSTRACT The carbonic anhydrase 2 (Car2) gene encodes the primary isoenzyme responsible for aqueous humor (AH) production and plays a major role in the regulation of intraocular pressure (IOP). The CRISPR-Cas9 system, based on the ShH10 adenovirus-associated virus, can efficiently disrupt the Car2 […]
Protection against Oxidative Stress by Coenzyme Q10 in a Porcine Retinal Degeneration Model
J Pers Med. 2024 Apr 22;14(4):437. doi: 10.3390/jpm14040437. ABSTRACT Oxidative stress plays an important role in neurodegenerative diseases, including glaucoma. Therefore, we analyzed if the antioxidant coenzyme Q10 (CoQ10), which is also commercially available, can prevent retinal degeneration induced by hydrogen peroxide (H2O2) in a porcine organ culture model. Retinal explants were cultivated for eight […]
Comprehensive Diagnosis, Treatment, and Outcome of Taenia crassiceps Cysticercosis in a Ring-Tailed Lemur (Lemur catta) from a Croatian Zoo: No Longer Unusual?
Pathogens. 2024 Mar 27;13(4):283. doi: 10.3390/pathogens13040283. ABSTRACT Taenia crassiceps is a zoonotic tapeworm of the genus Taenia that is distributed throughout the Northern Hemisphere. Wild and domestic carnivores are final hosts, while rodents and rabbits are primarily intermediate hosts, although many other mammals may harbour the larval stage, Cysticercus longicollis. This case report aims to […]