Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood
Int J Mol Sci. 2023 Nov 16;24(22):16406. doi: 10.3390/ijms242216406. ABSTRACT Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased levels of reactive oxygen species lead to damaged mitochondrial DNA (mtDNA), resulting in dysfunctional mitochondria, and, consequently, mtDNA causes further harm in the […]
HLA-Homozygous iPSC-Derived Mesenchymal Stem Cells Rescue Rotenone-Induced Experimental Leber’s Hereditary Optic Neuropathy-like Models In Vitro and In Vivo
Cells. 2023 Nov 13;12(22):2617. doi: 10.3390/cells12222617. ABSTRACT BACKGROUND: Mesenchymal stem cells (MSCs) hold promise for cell-based therapy, yet the sourcing, quality, and invasive methods of MSCs impede their mass production and quality control. Induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) can be infinitely expanded, providing advantages over conventional MSCs in terms of meeting unmet clinical […]
The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways
Food Funct. 2023 Nov 22. doi: 10.1039/d3fo03568a. Online ahead of print. ABSTRACT Previous studies have indicated that NaIO3 induces intracellular reactive oxygen species (ROS) production and has been used as a model for age-related macular degeneration (AMD) due to the selective retinal pigment epithelium (RPE) cell damage it induces. Beta-mangostin (BM) is a xanthone-type natural […]
A comprehensive analysis of library preparation methods shows high heterogeneity of extrachromosomal circular DNA but distinct chromosomal amount levels reflecting different cell states
Analyst. 2023 Nov 21. doi: 10.1039/d3an01300f. Online ahead of print. ABSTRACT Extrachromosomal circular DNA (eccDNA) was discovered several decades ago, but little is known about its function. With the development of sequencing technology, several library preparation methods have been developed to elucidate the biogenesis and function of eccDNA. However, different treatment methods have certain biases […]
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy
Adv Sci (Weinh). 2023 Nov 20:e2302776. doi: 10.1002/advs.202302776. Online ahead of print. ABSTRACT Activation of hypoxia-inducible factor 1α (HIF1α) contributes to blood-retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitochondrial biology is altered to adapt to the ischemic environment created by initial vascular dysfunction, but […]
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy
J Mol Med (Berl). 2023 Nov 20. doi: 10.1007/s00109-023-02389-2. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main symptom. It is one of the diseases that cause vision loss and optic atrophy in young and middle-aged people. The mutations of these three […]
Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway
Cell Death Discov. 2023 Nov 18;9(1):419. doi: 10.1038/s41420-023-01712-7. ABSTRACT Cellular senescence is a hallmark of aging and has been linked to age-related diseases. Age-related macular degeneration (AMD), the most common aging-related retinal disease, is prospectively associated with retinal pigment epithelial (RPE) senescence. However, the mechanism of RPE cell senescence remains unknown. In this study, tert-butyl […]
Retinal ischemia-reperfusion injury induces intense lipid synthesis and remodeling
Biochem Biophys Res Commun. 2023 Nov 10;689:149232. doi: 10.1016/j.bbrc.2023.149232. Online ahead of print. ABSTRACT The retina is a high-metabolism tissue composed of various cell types with complex functions that relies heavily on the blood supply to maintain homeostasis. Retinal ischemia-reperfusion injury is a critical pathogenic mechanism in glaucoma, and changes in lipid molecules may lead […]
Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis
Sci Rep. 2023 Nov 17;13(1):20145. doi: 10.1038/s41598-023-46104-0. ABSTRACT Retinal ischemia‒reperfusion (I/R) injury can cause significant damage to human retinal neurons, greatly compromising their functions. Existing interventions have been proven to have little effect. Ferroptosis is a newly discovered type of programmed cell death that has been found to be involved in the process of ischemia‒reperfusion […]
Mitochondria-targeted SkQ1 nanoparticles for dry eye disease: Inhibiting NLRP3 inflammasome activation by preventing mitochondrial DNA oxidation
J Control Release. 2023 Nov 14:S0168-3659(23)00738-1. doi: 10.1016/j.jconrel.2023.11.021. Online ahead of print. ABSTRACT Dry eye disease (DED) is a multifactorial ocular surface disorder mutually promoted by reactive oxygen species (ROS) and ocular surface inflammation. NLRP3 is the key regulator for inducing ocular surface inflammation in DED. However, the mechanism by which ROS influences the bio-effects […]