Category: Ophthalmology AND mitochondrial

Ochratoxin A induces mitochondrial dysfunction, oxidative stress, and apoptosis of retinal ganglion cells (RGCs), leading to retinal damage in mice

Int Ophthalmol. 2024 Feb 13;44(1):72. doi: 10.1007/s10792-024-03032-w. ABSTRACT PURPOSE: Ochratoxin A (OTA) contamination of food and feed is a serious problem worldwide. OTA is considered a carcinogen and immunotoxic, nephrotoxic, and neurotoxic mycotoxin. The present study aims to determine the toxic effects of OTA on retinal ganglion cells (RGCs) and assess the resulting impairment of […]

Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre

Br J Ophthalmol. 2024 Feb 12:bjo-2023-323557. doi: 10.1136/bjo-2023-323557. Online ahead of print. ABSTRACT AIMS: To investigate the clinical characteristics of Leber hereditary optic neuropathy (LHON) with mtDNA primary mutations to better understand features associated with prognosis. METHODS: This study enrolled 1540 LHON patients from 1516 unrelated families genetically confirmed by Sanger or whole-mitochondrial sequencing between […]

Novel ability of diflubenzuron as an inhibitor of mitochondrial function

Insect Biochem Mol Biol. 2024 Feb 9:104088. doi: 10.1016/j.ibmb.2024.104088. Online ahead of print. ABSTRACT Compounds classified as benzoylphenylurea (BPU), such as diflubenzuron (DFB), are used as insecticides. Although BPU disrupts molting by inhibiting chitin biosynthesis and exhibits insecticidal activity, their exact mode of action remains unknown. Since epidermal cells proliferate and morphologically change from squamous […]

Age-Related Macular Degeneration and Mitochondria-Associated Autoantibodies: A Review of the Specific Pathogenesis and Therapeutic Strategies

Int J Mol Sci. 2024 Jan 28;25(3):1624. doi: 10.3390/ijms25031624. ABSTRACT Age-related macular degeneration (AMD) is a severe retinal disease that causes irreversible visual loss and blindness in elderly populations worldwide. The pathological mechanism of AMD is complex, involving the interactions of multiple environmental and genetic factors. A poor understanding of the disease leads to limited […]

Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Curr Med Sci. 2024 Feb 10. doi: 10.1007/s11596-024-2832-z. Online ahead of print. ABSTRACT Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringently […]

Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

iScience. 2024 Jan 19;27(2):108979. doi: 10.1016/j.isci.2024.108979. eCollection 2024 Feb 16. ABSTRACT A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In the liver, genes associated with […]

Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage

Front Cell Neurosci. 2024 Jan 25;18:1354569. doi: 10.3389/fncel.2024.1354569. eCollection 2024. ABSTRACT Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of their axons, as well as damage and remodeling of the lamina cribrosa are the main events […]

Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models

Nat Protoc. 2024 Feb 8. doi: 10.1038/s41596-023-00947-z. Online ahead of print. ABSTRACT Finite-difference time-domain (FDTD) electromagnetic simulations are a computational method that has seen much success in the study of biological optics; however, such simulations are often hindered by the difficulty of faithfully replicating complex biological microstructures in the simulation space. Recently, we designed simulations […]