Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway
iScience. 2024 Jul 8;27(8):110448. doi: 10.1016/j.isci.2024.110448. eCollection 2024 Aug 16. ABSTRACT Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage. In this study, we found that corosolic acid (CA), also known as plant insulin, significantly protects […]
Ferroptosis contributes to diabetes-induced visual pathway neuronal damage via iron accumulation and GPX4 inactivation
Metab Brain Dis. 2024 Jul 30. doi: 10.1007/s11011-024-01398-5. Online ahead of print. ABSTRACT The damage of the diabetic visual pathway is one of the main causes of blindness in diabetic patients. Visual pathways include anatomic parts from the retina to the occipital lobe. This study investigated the involvement of ferroptosis, a planned cell death brought […]
TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia
Cell Death Differ. 2024 Jul 30. doi: 10.1038/s41418-024-01349-8. Online ahead of print. ABSTRACT Progressive dysfunction of the retinal pigment epithelium (RPE) and the adjacent photoreceptor cells in the outer retina plays a pivotal role in the pathogenesis of diabetic retinopathy (DR). Here, we observed a marked increase in oxidative stress-induced apoptosis in parallel with higher […]
Axonal mitophagy in retinal ganglion cells
Cell Commun Signal. 2024 Jul 29;22(1):382. doi: 10.1186/s12964-024-01761-0. ABSTRACT Neurons, exhibiting unique polarized structures, rely primarily on the mitochondrial production of ATP to maintain their hypermetabolic energy requirements. To maintain a normal energy supply, mitochondria are transported to the distal end of the axon. When mitochondria within the axon are critically damaged beyond their compensatory […]
The Surviving, Not Thriving, Photoreceptors in Patients with ABCA4 Stargardt Disease
Diagnostics (Basel). 2024 Jul 17;14(14):1545. doi: 10.3390/diagnostics14141545. ABSTRACT Stargardt disease (STGD1), associated with biallelic variants in the ABCA4 gene, is the most common heritable macular dystrophy and is currently untreatable. To identify potential treatment targets, we characterized surviving STGD1 photoreceptors. We used clinical data to identify macular regions with surviving STGD1 photoreceptors. We compared the […]
A Preliminary Study of the Occurrence of Genetic Changes in mtDNA in the Muscles in Children Treated for Strabismus
J Clin Med. 2024 Jul 10;13(14):4041. doi: 10.3390/jcm13144041. ABSTRACT Background: The dysregulation of extraocular muscles (EOMs) in the strabismus may be partly due to modification in the mitochondrial DNA (mtDNA). Currently, little is known about changes occurring in mtDNA of EOMs in patients with strabismus, therefore the aim of our study was to analyze if […]
The Role of HIF-1α in Retinopathy of Prematurity: A Review of Current Literature
J Clin Med. 2024 Jul 10;13(14):4034. doi: 10.3390/jcm13144034. ABSTRACT Hypoxia-inducible factor (HIF) plays a crucial role in regulating oxygen sensing and adaptation at the cellular level, overseeing cellular oxygen homeostasis, erythrocyte production, angiogenesis, and mitochondrial metabolism. The hypoxia-sensitive HIF-1α subunit facilitates tissue adaptation to hypoxic conditions, including the stimulation of proangiogenic factors. Retinopathy of prematurity […]
Genetic Analysis of 252 Index Cases with Inherited Retinal Diseases Using a Panel of 351 Retinal Genes
Genes (Basel). 2024 Jul 16;15(7):926. doi: 10.3390/genes15070926. ABSTRACT Inherited retinal diseases (IRDs) are extremely heterogeneous with at least 350 causative genes, complicating the process of genetic diagnosis. We analyzed samples of 252 index cases with IRDs using the Blueprint Genetics panel for “Retinal Dystrophy” that includes 351 genes. The cause of disease could be identified […]
Lactate/lactylation in ocular development and diseases
Trends Mol Med. 2024 Jul 24:S1471-4914(24)00187-4. doi: 10.1016/j.molmed.2024.07.001. Online ahead of print. ABSTRACT Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, […]
OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN PRESUMED VETERINARY ANTHELMINTIC DRUG-INDUCED RETINAL TOXICITY: A Glimpse into Underlying Mechanism
Retina. 2024 Aug 1;44(8):1456-1462. doi: 10.1097/IAE.0000000000004128. ABSTRACT PURPOSE: To report optical coherence tomography findings of presumed veterinary anthelmintic drugs (VADs)-induced retinal toxicity that may aid in understanding potential pathogenic mechanisms. METHODS: This is a retrospective observational case series analysis of patients with vision abnormalities following the accidental or intentional consumption of veterinary anthelmintic drugs. All […]