Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models
Nat Protoc. 2024 Feb 8. doi: 10.1038/s41596-023-00947-z. Online ahead of print. ABSTRACT Finite-difference time-domain (FDTD) electromagnetic simulations are a computational method that has seen much success in the study of biological optics; however, such simulations are often hindered by the difficulty of faithfully replicating complex biological microstructures in the simulation space. Recently, we designed simulations […]
Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis
Eye (Lond). 2024 Feb 7. doi: 10.1038/s41433-024-02951-3. Online ahead of print. NO ABSTRACT PMID:38326485 | DOI:10.1038/s41433-024-02951-3
Serum amyloid A and mitochondrial DNA in extracellular vesicles are novel markers for detecting traumatic brain injury in a mouse model
iScience. 2024 Jan 17;27(2):108932. doi: 10.1016/j.isci.2024.108932. eCollection 2024 Feb 16. ABSTRACT This study investigates the potential use of circulating extracellular vesicles’ (EVs) DNA and protein content as biomarkers for traumatic brain injury (TBI) in a mouse model. Despite an overall decrease in EVs count during the acute phase, there was an increased presence of exosomes […]
Mitochondrial stress: a key role of neuroinflammation in stroke
J Neuroinflammation. 2024 Feb 6;21(1):44. doi: 10.1186/s12974-024-03033-7. ABSTRACT Stroke is a clinical syndrome characterized by an acute, focal neurological deficit, primarily caused by the occlusion or rupture of cerebral blood vessels. In stroke, neuroinflammation emerges as a pivotal event contributing to neuronal cell death. The occurrence and progression of neuroinflammation entail intricate processes, prominently featuring […]
Functional consequences of familial ALS-associated SOD1L84F in neuronal and muscle cells
FASEB J. 2024 Feb 15;38(3):e23461. doi: 10.1096/fj.202301979R. ABSTRACT Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by progressive skeletal muscle denervation and loss of motor neurons that results in muscle atrophy and eventual death due to respiratory failure. Previously, we identified a novel SOD1L84F variation in a familial ALS case. In this study, we […]
Consequences of exposure to particulate matter on the ocular surface: Mechanistic insights from cellular mechanisms to epidemiological findings
Environ Pollut. 2024 Feb 2:123488. doi: 10.1016/j.envpol.2024.123488. Online ahead of print. ABSTRACT Exposure to air pollutants, especially in the case of particulate matter (PM), poses significant health risks throughout the body. The ocular surface is directly exposed to atmospheric PM making it challenging to avoid. This constant exposure makes the ocular surface a valuable model […]
Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber’s hereditary optic neuropathy in vitro
J Chin Med Assoc. 2024 Feb 2. doi: 10.1097/JCMA.0000000000001063. Online ahead of print. ABSTRACT BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is mainly the degeneration of retinal ganglion cells (RGCs) associated with high apoptosis and reactive oxygen species (ROS) levels, which is accepted to be caused by the mutations in the subunits of complex I of […]
Optic Neuropathy Associated with POLG Mutations: A Case Series and Literature Review
J Neuroophthalmol. 2024 Jan 31. doi: 10.1097/WNO.0000000000002089. Online ahead of print. ABSTRACT BACKGROUND: The clinical characteristics of patients with polymerase gamma (POLG) mutation-associated optic neuropathy remain incompletely characterized. METHODS: We describe the clinical characteristics of 3 patients with POLG-associated optic neuropathy. We performed a literature review of optic neuropathy cases associated with POLG mutations and […]
Damage to the orbicularis oculi muscle may impair the development of dermatochalasis
Sci Rep. 2024 Jan 29;14(1):2417. doi: 10.1038/s41598-024-52955-y. ABSTRACT The purpose of this article is to investigate the changes that occur in the orbicularis oculi muscle (OOM) in patients with dermatochalasis. The OOM specimens from 26 patients were collected during upper eyelid blepharoplasty. Each specimen was divided into three parts, which were then examined using different […]
miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway
J Ophthalmol. 2024 Jan 19;2024:1470898. doi: 10.1155/2024/1470898. eCollection 2024. ABSTRACT PURPOSE: Diabetic retinopathy (DR) is an ocular disease caused by diabetes and may lead to vision impairment and even blindness. Oxidative stress and inflammation are two key pathogenic factors of DR. Recently, regulatory roles of different microRNAs (miRNAs) in DR have been widely verified. miR-26a-5p […]