Thiostrepton induces oxidative stress, mitochondrial dysfunction and ferroptosis in HaCaT cells
Cell Signal. 2024 Jul 3:111285. doi: 10.1016/j.cellsig.2024.111285. Online ahead of print. ABSTRACT TST has been mainly studied for its anti-tumor proliferation and antimicrobial effects, but not widely used in dermatological diseases. The mechanism of cellular damage by TST in response to H2O2-mediated oxidative stress was investigated in human skin immortalized keratinocytes (HaCaT) as an in […]
Leber hereditary optic neuropathy in Czechia and Slovakia: Quality of life and costs from patient perspective
Heliyon. 2024 May 31;10(11):e32296. doi: 10.1016/j.heliyon.2024.e32296. eCollection 2024 Jun 15. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is the most frequent mitochondrial disease causing dyschromatopsia and progressive central visual loss that is subacute in progression and painless. Several studies have been published assessing QoL in patients with LHON, but no estimate of the economic burden […]
The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis
Cell Signal. 2024 Jul 1:111283. doi: 10.1016/j.cellsig.2024.111283. Online ahead of print. ABSTRACT It has been demonstrated that circular RNAs (circRNAs) are associated with the development of diabetic retinopathy (DR). Nevertheless, the function of circSLC16A10 in the development of DR remains unclear. In order to investigate the role of circSLC16A10, we employed cell and animal models […]
Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition
Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1. doi: 10.1167/iovs.65.8.1. ABSTRACT PURPOSE: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible blindness. GIG is characterized by the abnormal deposition of extracellular matrix (ECM) in the trabecular meshwork (TM), elevation of intraocular pressure (IOP), and loss of retinal ganglion cells (RGCs). The […]
Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2
J Clin Invest. 2024 Jul 1;134(13):e175560. doi: 10.1172/JCI175560. ABSTRACT Mitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy […]
PET Imaging for The Early Evaluation of Ocular Inflammation in Diabetic Rats by Using [18F]-DPA-714
Exp Eye Res. 2024 Jun 28:109986. doi: 10.1016/j.exer.2024.109986. Online ahead of print. ABSTRACT Ocular complications of diabetes mellitus (DM) are the leading cause of vision loss. Ocular inflammation often occurs in the early stage of DM; however, there are no proven quantitative methods to evaluate the inflammatory status of eyes in DM. The 18 kDa […]
Corrigendum to “Mitochondrial DNA has a pro-inflammatory role in AMD” [Biochim. Biophys. Acta 1853 (2015) 2897-2906]
Biochim Biophys Acta Mol Cell Res. 2024 Jun 28:119790. doi: 10.1016/j.bbamcr.2024.119790. Online ahead of print. NO ABSTRACT PMID:38944555 | DOI:10.1016/j.bbamcr.2024.119790
Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy
Mitochondrion. 2024 Jun 27:101925. doi: 10.1016/j.mito.2024.101925. Online ahead of print. ABSTRACT In diabetic retinopathy, mitochondrial DNA (mtDNA) is damaged and mtDNA-encoded genes and long noncoding RNA cytochrome B (LncCytB) are downregulated. LncRNAs lack an open reading frame, but they can regulate gene expression by associating with DNA/RNA/protein. Double stranded mtDNA has promoters on both heavy […]
Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progression
Cell Death Dis. 2024 Jun 28;15(6):464. doi: 10.1038/s41419-024-06790-8. ABSTRACT The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying intracranial glioblastoma progression. Our findings demonstrate that the mitochondria-derived peptide, humanin, plays a significant role in enhancing glioblastoma progression through the intratumoral activation of the […]
Effects of organophosphorus flame retardant EHDPP on mouse retinal photoreceptor cells: Oxidative stress, apoptosis, and proinflammatory response
Ecotoxicol Environ Saf. 2024 Jun 26;281:116640. doi: 10.1016/j.ecoenv.2024.116640. Online ahead of print. ABSTRACT 2-Ethylhexyl diphenyl phosphate (EHDPP) is a frequently utilized organophosphorus flame retardant (OPFR) and has been extensively detected in environmental media. Prolonged daily exposure to EHDPP has been linked to potential retinal damage, yet the adverse impacts on the retina are still generally […]