Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma
Sci Rep. 2024 Feb 15;14(1):3834. doi: 10.1038/s41598-024-54075-z. ABSTRACT Glaucoma is a prevalent cause of blindness globally, characterized by the progressive degeneration of retinal ganglion cells (RGCs). Among various factors, glutamate excitotoxicity stands out as a significant contributor of RGCs loss in glaucoma. Our study focused on Ripa-56 and its protective effect against NMDA-induced retinal damage […]
A Japanese Case of Leber’s Hereditary Optic Neuropathy with the m.13051G>A Pathogenic Variant
Neuroophthalmology. 2024 Feb 12;48(1):51-55. doi: 10.1080/01658107.2023.2273480. eCollection 2024. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is one of the hereditary optic neuropathies and is principally caused by three frequent mitochondria deoxyribonucleic acid (DNA) pathogenic variants (m.11778 G>A, m.3460 G>A, and m.14484T>C). These pathogenic variants account for 90% of LHON cases, with rare pathogenic variants accounting for […]
Ochratoxin A induces mitochondrial dysfunction, oxidative stress, and apoptosis of retinal ganglion cells (RGCs), leading to retinal damage in mice
Int Ophthalmol. 2024 Feb 13;44(1):72. doi: 10.1007/s10792-024-03032-w. ABSTRACT PURPOSE: Ochratoxin A (OTA) contamination of food and feed is a serious problem worldwide. OTA is considered a carcinogen and immunotoxic, nephrotoxic, and neurotoxic mycotoxin. The present study aims to determine the toxic effects of OTA on retinal ganglion cells (RGCs) and assess the resulting impairment of […]
Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre
Br J Ophthalmol. 2024 Feb 12:bjo-2023-323557. doi: 10.1136/bjo-2023-323557. Online ahead of print. ABSTRACT AIMS: To investigate the clinical characteristics of Leber hereditary optic neuropathy (LHON) with mtDNA primary mutations to better understand features associated with prognosis. METHODS: This study enrolled 1540 LHON patients from 1516 unrelated families genetically confirmed by Sanger or whole-mitochondrial sequencing between […]
Novel ability of diflubenzuron as an inhibitor of mitochondrial function
Insect Biochem Mol Biol. 2024 Feb 9:104088. doi: 10.1016/j.ibmb.2024.104088. Online ahead of print. ABSTRACT Compounds classified as benzoylphenylurea (BPU), such as diflubenzuron (DFB), are used as insecticides. Although BPU disrupts molting by inhibiting chitin biosynthesis and exhibits insecticidal activity, their exact mode of action remains unknown. Since epidermal cells proliferate and morphologically change from squamous […]
p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway
Cell Rep Med. 2024 Feb 5:101401. doi: 10.1016/j.xcrm.2024.101401. Online ahead of print. ABSTRACT The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. TAp63 is induced in HSCs from animal models and […]
Age-Related Macular Degeneration and Mitochondria-Associated Autoantibodies: A Review of the Specific Pathogenesis and Therapeutic Strategies
Int J Mol Sci. 2024 Jan 28;25(3):1624. doi: 10.3390/ijms25031624. ABSTRACT Age-related macular degeneration (AMD) is a severe retinal disease that causes irreversible visual loss and blindness in elderly populations worldwide. The pathological mechanism of AMD is complex, involving the interactions of multiple environmental and genetic factors. A poor understanding of the disease leads to limited […]
Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases
Curr Med Sci. 2024 Feb 10. doi: 10.1007/s11596-024-2832-z. Online ahead of print. ABSTRACT Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringently […]
Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage
Front Cell Neurosci. 2024 Jan 25;18:1354569. doi: 10.3389/fncel.2024.1354569. eCollection 2024. ABSTRACT Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of their axons, as well as damage and remodeling of the lamina cribrosa are the main events […]
Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models
Nat Protoc. 2024 Feb 8. doi: 10.1038/s41596-023-00947-z. Online ahead of print. ABSTRACT Finite-difference time-domain (FDTD) electromagnetic simulations are a computational method that has seen much success in the study of biological optics; however, such simulations are often hindered by the difficulty of faithfully replicating complex biological microstructures in the simulation space. Recently, we designed simulations […]