Polarity-Driven Fluorescence Monitoring of Lipid Droplet Dynamics in Dry Eye Disease
Anal Chem. 2024 Jun 3. doi: 10.1021/acs.analchem.4c01366. Online ahead of print. ABSTRACT The emergence of lipid droplets (LDs) has been recognized as cellular markers of ocular surface hyperosmosis, which is recognized as a fundamental mechanism driving dry eye disease (DED), while their dynamics during DED progression and therapy remains unlocked. For this purpose, an LD-specific […]
Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling
Acta Pharm Sin B. 2024 Jun;14(6):2613-2630. doi: 10.1016/j.apsb.2024.03.011. Epub 2024 Mar 10. ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) protect against diabetic cardiovascular diseases and nephropathy. However, their activity in diabetic retinopathy (DR) remains unclear. Our retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other […]
PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium
Cell Death Dis. 2024 Jun 1;15(6):385. doi: 10.1038/s41419-024-06762-y. ABSTRACT Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration (AMD). Lipid droplets are also reported in the retinal pigment epithelium (RPE) from AMD donor eyes. However, the mechanisms underlying these disease phenotypes remain elusive. […]
Biomarker evidence of early vision and rod energy-linked pathophysiology benefits from very low dose DMSO in 5xFAD mice
Acta Neuropathol Commun. 2024 May 31;12(1):85. doi: 10.1186/s40478-024-01799-8. ABSTRACT Here, we test whether early visual and OCT rod energy-linked biomarkers indicating pathophysiology in nicotinamide nucleotide transhydrogenase (Nnt)-null 5xFAD mice also occur in Nnt-intact 5xFAD mice and whether these biomarkers can be pharmacologically treated. Four-month-old wild-type or 5xFAD C57BL/6 substrains with either a null (B6J) Nnt […]
Clinician-Driven Reanalysis of Exome Sequencing Data From Patients With Inherited Retinal Diseases
JAMA Netw Open. 2024 May 1;7(5):e2414198. doi: 10.1001/jamanetworkopen.2024.14198. ABSTRACT IMPORTANCE: Despite advances in next-generation sequencing (NGS), a significant proportion of patients with inherited retinal disease (IRD) remain undiagnosed after initial genetic testing. Exome sequencing (ES) reanalysis in the clinical setting has been suggested as one method for improving diagnosis of IRD. OBJECTIVE: To investigate the […]
Prevalence of Leber hereditary optic neuropathy in the Community of Madrid (Spain), estimation with a capture-recapture method
Orphanet J Rare Dis. 2024 May 29;19(1):220. doi: 10.1186/s13023-024-03225-7. ABSTRACT BACKGROUND: Leber hereditary optic neuropathy (LHON) typically presents in young adults as bilateral painless subacute visual loss. Prevalence data are scarce. The aim of this study was to examine the validity of different ascertainment sources used in population-based rare diseases registries to detect cases, and […]
Spatial detection of mitochondrial DNA and RNA in tissues
Front Cell Dev Biol. 2024 May 14;12:1346778. doi: 10.3389/fcell.2024.1346778. eCollection 2024. ABSTRACT BACKGROUND: Mitochondrial health has gained attention in a number of diseases, both as an indicator of disease state and as a potential therapeutic target. The quality and amount of mitochondrial DNA (mtDNA) and RNA (mtRNA) can be important indicators of mitochondrial and cell […]
miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia
J Transl Med. 2024 May 28;22(1):511. doi: 10.1186/s12967-024-05288-3. ABSTRACT BACKGROUND: Myopia is one of the eye diseases that can damage the vision of young people. This study aimed to explore the protective role of miR-92b-3p against DNA damage and apoptosis in retinal tissues of negative lens-induced myopic (LIM) guinea pigs by targeting BTG2. METHODS: Biometric […]
Rosmarinic acid alleviates fungal keratitis caused by Aspergillus fumigatus by inducing macrophage autophagy
Exp Eye Res. 2024 May 24:109944. doi: 10.1016/j.exer.2024.109944. Online ahead of print. ABSTRACT Fungal keratitis (FK) is an infectious keratopathy can casue serious damage to vision. Its severity is related to the virulence of fungus and response of inflammatory. Rosmarinic acid (RA) extracted from Rosmarinus officinalis exhibits antioxidant, anti-inflammatory and anti-viral properties. The aim of […]
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome
Free Radic Biol Med. 2024 May 24:S0891-5849(24)00467-2. doi: 10.1016/j.freeradbiomed.2024.05.032. Online ahead of print. ABSTRACT PURPOSE: Severe dry eye disease causes ocular surface damage, which is highly associated with mitochondrial dysfunction. Mitochondrial transcription factor A (TFAM) is essential for packaging mitochondrial DNA (mtDNA) and is crucial for maintaining mitochondrial function. Herein, we aimed to explore the […]