Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone
Vision Res. 2024 Jul 10;222:108456. doi: 10.1016/j.visres.2024.108456. Online ahead of print. ABSTRACT Although biomechanical changes of the trabecular meshwork (TM) are important to the pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in the underlying molecular mechanisms of the development of it. In this study, we performed intravitreal triamcinolone injection (IVTA) in […]
Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
Cell Commun Signal. 2024 Jul 11;22(1):359. doi: 10.1186/s12964-024-01710-x. ABSTRACT PURPOSE: Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach available for BCD patients. Previous research has suggested that polyunsaturated fatty acids (PUFAs) may play a significant role in the development […]
A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria
Neural Regen Res. 2025 Apr 1;20(4):1081-1082. doi: 10.4103/NRR.NRR-D-24-00222. Epub 2024 Jun 3. NO ABSTRACT PMID:38989941 | DOI:10.4103/NRR.NRR-D-24-00222
Leber’s hereditary optic neuropathy: Update on current diagnosis and treatment
Front Ophthalmol (Lausanne). 2023 Jan 11;2:1077395. doi: 10.3389/fopht.2022.1077395. eCollection 2022. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a fairly prevalent mitochondrial disorder (1:50,000) arising from the dysfunction of the mitochondrial respiratory chain, which eventually leads to apoptosis of retinal ganglion cells. The usual presentation is that of a young male with a sequential reduction in […]
Flavoprotein fluorescence elevation is a marker of mitochondrial oxidative stress in patients with retinal disease
Front Ophthalmol (Lausanne). 2023 Feb 16;3:1110501. doi: 10.3389/fopht.2023.1110501. eCollection 2023. ABSTRACT PURPOSE: Recent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating […]
microRNA 146a ameliorates retinal damage in experimental autoimmune uveitis
Front Ophthalmol (Lausanne). 2023 Mar 24;3:1130202. doi: 10.3389/fopht.2023.1130202. eCollection 2023. ABSTRACT INTRODUCTION: Uveitis and related intraocular inflammations are a major cause of blindness due to retinal damage caused by degeneration and loss of the photoreceptor cells. In mouse experimental autoimmune uveitis (EAU) previously we have shown mitochondrial oxidative stress with marked upregulation of αA crystallin […]
Proposing a Neurotropic Etiology for Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis
Front Ophthalmol (Lausanne). 2022 Jan 10;1:802962. doi: 10.3389/fopht.2021.802962. eCollection 2021. ABSTRACT PURPOSE: To reassess the underlying pathophysiology of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinitis (RPC) through comparison with the non-inoculated eye of the von Szily animal model of neurotropic viral retinal infection. METHODS: Narrative review. RESULTS: Literature reports of isolated […]
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
World J Diabetes. 2024 Jun 15;15(6):1317-1339. doi: 10.4239/wjd.v15.i6.1317. ABSTRACT BACKGROUND: Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR. AIM: To determine the HYWZF prevention mechanisms, especially those underlying mitophagy. METHODS: Human retinal capillary endothelial cells (HRCECs) were treated with high glucose […]
A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s hereditary optic neuropathy
Clin Case Rep. 2024 Jul 8;12(7):e9045. doi: 10.1002/ccr3.9045. eCollection 2024 Jul. ABSTRACT We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber’s hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion. PMID:38979087 | PMC:PMC11228619 | DOI:10.1002/ccr3.9045
Metabolomic Disparities in Intraocular Fluid Across Varied Stages of Cataract Progression: Implications for the Analysis of Cataract Development
J Ocul Pharmacol Ther. 2024 Jul 8. doi: 10.1089/jop.2024.0067. Online ahead of print. ABSTRACT Introduction: The lens’s metabolic demands are met through a continuous circulation of aqueous humor, encompassing a spectrum of components such as organic and inorganic ions, carbohydrates, glutathione, urea, amino acids, proteins, oxygen, carbon dioxide, and water. Metabolomics is a pivotal tool, […]