Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue
Proteomics Clin Appl. 2024 Jun 24:e202400018. doi: 10.1002/prca.202400018. Online ahead of print. ABSTRACT PURPOSE: Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of chronic kidney disease and end-stage renal disease. One potential mechanism underlying cellular dysfunction contributing to kidney disease is aberrant protein post-translational modifications. Lysine acetylation is […]
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA plus syndrome
JCI Insight. 2024 Jun 25:e180582. doi: 10.1172/jci.insight.180582. Online ahead of print. ABSTRACT Autosomal dominant optic atrophy plus (ADOA+) is characterized by primary optic nerve atrophy accompanied by a spectrum of degenerative neurological symptoms. Despite ongoing research, no effective treatments are currently available for this condition. Our study provided evidence for the pathogenicity of an unreported […]
TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma
bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.597951. doi: 10.1101/2024.06.07.597951. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to injury. Tlr4 is highly expressed in ocular tissues and is known to modulate inflammatory processes in both anterior and posterior segment tissues. […]
Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy
Folia Histochem Cytobiol. 2024 Jun 24. doi: 10.5603/fhc.98875. Online ahead of print. ABSTRACT INTRODUCTION: Diabetic cataract (DC) is a common ocular complication of diabetes. Mitofusin 2 (MFN2), a mitochondrial fusion protein, is involved in the pathogenesis of cataract and diabetic complications. However, its role and molecular mechanisms in DC remain unclear. MATERIALS AND METHODS: DC […]
Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Inflammation. 2024 Jun 23. doi: 10.1007/s10753-024-02076-5. Online ahead of print. ABSTRACT Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue damage. Nevertheless, precise targeted and efficient therapies are limited. Thus, studies into novel therapeutic targets for the management of autoimmune diseases are urgently needed. Radical […]
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
BMC Ophthalmol. 2024 Jun 21;24(1):268. doi: 10.1186/s12886-024-03524-4. ABSTRACT BACKGROUND: Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelial function remains unclear. This study aimed to determine the effect and possible mechanism of SD on […]
Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Cell Commun Signal. 2024 Jun 21;22(1):343. doi: 10.1186/s12964-024-01712-9. ABSTRACT Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phosphorylation. In our study, we examined the impact of POLRMT on angiogenesis and found that its silencing or knockout (KO) […]
Mitochondrial Retinopathy by MT-ATP6 Variant Revealed by Whole Genome Sequencing: A Case Report
Korean J Ophthalmol. 2024 Jun 19. doi: 10.3341/kjo.2024.0013. Online ahead of print. NO ABSTRACT PMID:38897591 | DOI:10.3341/kjo.2024.0013
NAD(+) Supplementation Improves Mitochondrial Functions and Normalizes Glaucomatous Trabecular Meshwork Features
Exp Cell Res. 2024 Jun 17:114137. doi: 10.1016/j.yexcr.2024.114137. Online ahead of print. ABSTRACT Glaucoma is characterized by pathological elevation of intraocular pressure (IOP) due to dysfunctional trabecular meshwork (TM), which is the primary cause of irreversible vision loss. There are currently no effective treatment strategies for glaucoma. Mitochondrial function plays a crucial role in regulating […]
Spinocerebellar ataxias: from pathogenesis to recent therapeutic advances
Front Neurosci. 2024 Jun 4;18:1422442. doi: 10.3389/fnins.2024.1422442. eCollection 2024. ABSTRACT Spinocerebellar ataxia is a phenotypically and genetically heterogeneous group of autosomal dominant-inherited degenerative disorders. The gene mutation spectrum includes dynamic expansions, point mutations, duplications, insertions, and deletions of varying lengths. Dynamic expansion is the most common form of mutation. Mutations often result in indistinguishable clinical […]