Atypical Late-Onset Leber Hereditary Optic Neuropathy (LHON) Associated With T14484C Mutation
J Neuroophthalmol. 2024 Jun 1;44(2):e224-e226. doi: 10.1097/WNO.0000000000001835. Epub 2023 Apr 19. NO ABSTRACT PMID:38741248 | DOI:10.1097/WNO.0000000000001835
Novel Mutations in the ND5 Gene Associated With Leber Hereditary Optic Neuropathy
J Neuroophthalmol. 2024 Jun 1;44(2):e227-e229. doi: 10.1097/WNO.0000000000001796. Epub 2023 Jan 4. NO ABSTRACT PMID:38741249 | DOI:10.1097/WNO.0000000000001796
“Resilience to diabetic retinopathy”
Prog Retin Eye Res. 2024 May 11:101271. doi: 10.1016/j.preteyeres.2024.101271. Online ahead of print. ABSTRACT Chronic elevation of blood glucose at first causes relatively minor changes to the neural and vascular components of the retina. As the duration of hyperglycemia persists, the nature and extent of damage increases and becomes readily detectable. While this second, overt […]
Association Between Corneal Changes and Retinal Oximetry in Diabetes Mellitus
Clin Ophthalmol. 2024 May 7;18:1235-1243. doi: 10.2147/OPTH.S456020. eCollection 2024. ABSTRACT PURPOSE: Diabetes mellitus (DM) causes different corneal changes that are associated with the severity of diabetic retinopathy. To identify the pathophysiological reasons for this, corneal tomography and optical densitometry (COD) were combined with retinal oximetry. METHODS: Patients with DM and healthy subjects were included in […]
New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases
J Histochem Cytochem. 2024 May 11:221554241249515. doi: 10.1369/00221554241249515. Online ahead of print. ABSTRACT Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and […]
Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells
Mol Biol Rep. 2024 May 10;51(1):637. doi: 10.1007/s11033-024-09595-2. ABSTRACT BACKGROUND: Retinal pigment epithelial cells (RPECs) are a type of retinal cells that structurally and physiologically support photoreceptors. However, hyperglycemia has been shown to play a critical role in the progression of diabetic retinopathy (DR), which is one of the leading causes of vision impairment. In […]
Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration
Front Ophthalmol (Lausanne). 2023;3:1306019. doi: 10.3389/fopht.2023.1306019. Epub 2023 Dec 5. ABSTRACT Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive understanding of the metabolic pathways essential to photoreceptor […]
Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage
J Nanobiotechnology. 2024 May 9;22(1):233. doi: 10.1186/s12951-024-02503-7. ABSTRACT BACKGROUND: Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients’ quality of life and social functioning. Currently, anti-inflammatory drugs […]
ADVANCES IN ALZHEIMER’S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION
Neurochem Int. 2024 May 7:105761. doi: 10.1016/j.neuint.2024.105761. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) remains one of the most formidable neurological disorders, affecting millions globally. This review provides a holistic overview of the therapeutic strategies, both conventional and novel, aimed at mitigating the impact of AD. Initially, we delve into the conventional approach, emphasizing […]
Inhibiting the SARM1-NAD+ axis reduces oxidative stress-induced damage to retinal and nerve cells
Int Immunopharmacol. 2024 May 8;134:112193. doi: 10.1016/j.intimp.2024.112193. Online ahead of print. ABSTRACT Retinal neurodegenerative diseases are a category of refractory blinding eye conditions closely associated with oxidative stress induced by mitochondrial dysfunction in retinal cells. SARM1, a core driver molecule leading to axonal degeneration, possesses NAD+ enzyme (NADase) activity. However, the role of the SARM1-NAD+ […]