mTOR Inhibitors Modulate the Biological Nature of TGF-β2-Treated or -Untreated Human Trabecular Meshwork Cells in Different Manners
Biomedicines. 2024 Nov 14;12(11):2604. doi: 10.3390/biomedicines12112604. ABSTRACT Background/Objectives: Mammalian target of rapamycin (mTOR) inhibition may have been suggested to have a beneficial effect on the glaucomatous human trabecular meshwork (HTM). To study the effects of the mTOR inhibitors rapamycin (Rapa) and Torin1 on the glaucomatous HTM, transforming growth factor-β2 (TGF-β2)-treated two-dimensionally (2D) and three-dimensionally (3D) […]
Methylglyoxal: A Key Factor for Diabetic Retinopathy and Its Effects on Retinal Damage
Biomedicines. 2024 Nov 2;12(11):2512. doi: 10.3390/biomedicines12112512. ABSTRACT Background: Diabetic retinopathy is the most common retinal vascular disease, affecting the retina’s blood vessels and causing chronic inflammation, oxidative stress, and, ultimately, vision loss. Diabetes-induced elevated glucose levels increase glycolysis, the main methylglyoxal (MGO) formation pathway. MGO is a highly reactive dicarbonyl and the most rapid glycation […]
FAN1 Deletion Variant in Basenji Dogs with Fanconi Syndrome
Genes (Basel). 2024 Nov 14;15(11):1469. doi: 10.3390/genes15111469. ABSTRACT Background: Fanconi syndrome is a disorder of renal proximal tubule transport characterized by metabolic acidosis, amino aciduria, glucosuria, and phosphaturia. There are acquired and hereditary forms of this disorder. A late-onset form of Fanconi syndrome in Basenjis was first described in 1976 and is now recognized as […]
Canine Multiple System Degeneration Associated with Sequence Variants in SERAC1
Genes (Basel). 2024 Oct 25;15(11):1378. doi: 10.3390/genes15111378. ABSTRACT Canine multiple system degeneration (CMSD) is an early onset, progressive movement disorder affecting Kerry Blue Terriers and Chinese Crested dogs. The associated pathologic lesions include degeneration of the cerebellum, caudate nucleus, and substantia nigra. CMSD is inherited as an autosomal recessive trait in both dog breeds. Previous […]
Ferroptosis in diabetic cardiomyopathy: from its mechanisms to therapeutic strategies
Front Endocrinol (Lausanne). 2024 Nov 11;15:1421838. doi: 10.3389/fendo.2024.1421838. eCollection 2024. ABSTRACT Diabetic cardiomyopathy (DCM) is defined as structural and functional cardiac abnormalities in diabetes, and cardiomyocyte death is the terminal event of DCM. Ferroptosis is iron-dependent oxidative cell death. Evidence has indicated that iron overload and ferroptosis play important roles in the pathogenesis of DCM. […]
Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review
Front Med (Lausanne). 2024 Nov 11;11:1472413. doi: 10.3389/fmed.2024.1472413. eCollection 2024. ABSTRACT OBJECTIVE: Sarcopenia is a significant healthcare challenge in the aging population. Oxidative stress (OS) is acknowledged to play a pivotal role in the pathological progression of sarcopenia. Numerous studies have demonstrated that mitigating or eliminating OS can ameliorate the pathological manifestations associated with sarcopenia. […]
Ellipsoid Zone Reflectivity: Exploring its Potential as a Novel Non-Invasive Biomarker for Assessing Mitochondrial Function
Neuroophthalmology. 2024 Jun 5;48(6):417-428. doi: 10.1080/01658107.2024.2341769. eCollection 2024. ABSTRACT The ellipsoid zone (EZ) on macular optical coherence tomography (OCT) scans exhibits high intensity due to a high density of light-scattering mitochondria, making its reflectivity a potential marker for mitochondrial function. Here, we developed a reliable analysis tool for extracting relative EZ reflectivity and explore its […]
Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects
bioRxiv [Preprint]. 2024 Nov 1:2024.11.01.621496. doi: 10.1101/2024.11.01.621496. ABSTRACT Human brain development is a complex process that requires intricate coordination of multiple cellular and developmental events. Dysfunction of lipid metabolism can lead to neurodevelopmental disorders. Lowe syndrome (LS) is a recessive X-linked disorder associated with proximal tubular renal disease, congenital cataracts and glaucoma, and central nervous […]
Respiratory Chain Complex I Deficiency in Leber Hereditary Optic Neuropathy: Insights from Ophthalmologic and Molecular Investigations in Tunisia
BMC Genomics. 2024 Nov 22;25(1):1133. doi: 10.1186/s12864-024-11060-0. ABSTRACT BACKGROUND: Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA (mtDNA) rare disease due to the pathogenic variant of the NADH dehydrogenase enzyme. LHON is characterized by a sudden central vision loss due to focal degeneration of the retinal ganglion cell layer and optic nerve. Symptoms usually […]
LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma
Cancer Sci. 2024 Nov 22. doi: 10.1111/cas.16379. Online ahead of print. ABSTRACT Long noncoding RNAs (lncRNAs) play pivotal roles in the development of human malignancies, though their involvement in oral squamous cell carcinoma (OSCC) remains incompletely understood. Using The Cancer Genome Atlas (TCGA) dataset, we analyzed expression of 7840 lncRNAs in primary head and neck […]