Metal-phenolic epigallocatechin gallate‑zinc antioxidant nanoparticles for cataract treatment
J Control Release. 2025 May 2:113798. doi: 10.1016/j.jconrel.2025.113798. Online ahead of print. ABSTRACT In cataract, oxidative stress plays an important role. It breaks the balance of the antioxidant defense system by destroying biological macromolecules such as proteins, lipids and nucleic acids in the lens, induces lens opacity, and then leads to the formation of cataract. […]
Valine acts as an early biomarker and exacerbates pathological cardiac hypertrophy by impairing mitochondrial quality control
Atherosclerosis. 2025 Apr 26;405:119216. doi: 10.1016/j.atherosclerosis.2025.119216. Online ahead of print. ABSTRACT OBJECTIVE: Pathological cardiac hypertrophy is an independent risk factor for heart failure (HF). Early identification and timely treatment are crucial for significantly delaying the progression of HF. METHODS: Targeted amino acid metabolomics and RNA sequencing (RNA-seq) were combined to explore the underlying mechanism. In […]
Chlamydia trachomatis infection induces ferroptosis and enhances chlamydial replication
Microb Pathog. 2025 Apr 30:107656. doi: 10.1016/j.micpath.2025.107656. Online ahead of print. ABSTRACT Chlamydia trachomatis (C. trachomatis) has been shown to activate multiple programmed cell death pathways, which contribute significantly to host immune responses. Nevertheless, the precise molecular mechanisms by which C. trachomatis induces cell death remain poorly characterized. Ferroptosis, a recently identified form of iron-dependent, […]
Angiotensinogen inhibition concurrently mitigates alcohol-associated hepatic and muscle injury
Metabolism. 2025 Apr 29:156275. doi: 10.1016/j.metabol.2025.156275. Online ahead of print. ABSTRACT AIMS: The organ communication mechanisms driven by alcohol-associated liver disease (ALD) remain inadequately understood. This study explores the endocrine roles of the hepatokine angiotensinogen (AGT) and the renin-angiotensin system (RAS) in ALD. METHODS AND RESULTS: Hepatokine screening tests revealed that chronic-binge ethanol consumption upregulates […]
Ursolic acid induces apoptosis in nasopharyngeal carcinoma cells through the P53 signaling pathway: a network pharmacology and experimental validation study
Med Oncol. 2025 May 1;42(6):189. doi: 10.1007/s12032-025-02749-7. ABSTRACT Nasopharyngeal carcinoma (NPC) is a malignant neoplasm that is highly prevalent in East Asia and presents significant therapeutic challenges due to limited treatment options and severe adverse effects. Ursolic acid (UA) is a pentacyclic triterpenoid with anticancer activity in various tumors; however, its mechanism of action in […]
Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis
Theranostics. 2025 Apr 9;15(11):5087-5105. doi: 10.7150/thno.105299. eCollection 2025. ABSTRACT Rationale: Pathological retinal angiogenesis with irregular and fragile vessels (also termed neovascularization, a response to hypoxia and dysmetabolism) is a leading cause of vision loss in all age groups. This process is driven in part through the energy deficiency in retinal neurons. Sustaining neural retinal metabolism […]
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer
Theranostics. 2025 Apr 13;15(11):5499-5517. doi: 10.7150/thno.113741. eCollection 2025. ABSTRACT Background: The disruption of mitochondrial homeostasis in acute kidney injury (AKI) is an important factor that drives persistent renal dysfunction. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown great therapeutic potential in AKI, but insufficient specificity of targeting the impaired mitochondrial function. Herein, we developed an […]
Mitochondria-Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function
Contact (Thousand Oaks). 2025 Apr 13;8:25152564251332141. doi: 10.1177/25152564251332141. eCollection 2025 Jan-Dec. ABSTRACT Sites of close apposition between organelles, known as membrane contact sites (MCSs), are critical regulators of organelle function. Mitochondria form elaborate reticular networks that perform essential metabolic and signaling functions. Many mitochondrial functions are regulated by MCSs formed between mitochondria and other organelles. […]
Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in Mice
Aging Cell. 2025 Apr 28:e70081. doi: 10.1111/acel.70081. Online ahead of print. ABSTRACT Age is a primary risk factor for chronic conditions, including age-related macular degeneration (AMD). Impairments in autophagy processes are implicated in AMD progression, but the extent of autophagy’s contribution and its therapeutic potential remain ambiguous. This study investigated age-associated transcriptomic changes in autophagy […]
Targeting mitochondrial DNA-STING-NF-kappaB Axis-mediated microglia activation by cryptotanshinone alleviates ischemic retinopathy
Phytomedicine. 2025 Apr 18;142:156779. doi: 10.1016/j.phymed.2025.156779. Online ahead of print. ABSTRACT BACKGROUND: Ischemic retinopathy, a leading cause of vision impairment, involves oxidative stress and dysregulated inflammation, with microglia playing a key role. Cryptotanshinone (CTS), a bioactive compound from Salvia miltiorrhiza, exhibits anti-inflammatory and antioxidant properties and thus has the potential for development as a therapeutic […]