Category: Ophthalmology AND mitochondrial

Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion

Front Pharmacol. 2024 Oct 22;15:1485831. doi: 10.3389/fphar.2024.1485831. eCollection 2024. ABSTRACT INTRODUCTION: Mitochondrial dysfunction and oxidative stress play important roles in diabetic retinal vascular injuries. Honokiol (HKL) is a small-molecule polyphenol that exhibits antioxidant effects and has a beneficial effect in diabetes. This study aimed to explore the potential ability of HKL to ameliorate vascular injury […]

Mutation of CRYAB encoding a conserved mitochondrial chaperone and anti-apoptotic protein causes hereditary optic atrophy

JCI Insight. 2024 Nov 19:e182209. doi: 10.1172/jci.insight.182209. Online ahead of print. ABSTRACT The degeneration of retinal ganglion cells (RGC) due to mitochondrial dysfunctions manifests optic neuropathy. However, the molecular components of RGC linked to optic neuropathy manifestations remain largely unknown. Here, we identified a novel optic atrophy-causative CRYAB gene encoding a highly conserved major lens […]

Long noncoding RNAs and metabolic memory associated with continued progression of diabetic retinopathy

J Diabetes. 2024 Nov;16(11):e70009. doi: 10.1111/1753-0407.70009. ABSTRACT Progression of diabetic retinopathy resists arrest even after institution of intensive glycemic control, suggesting a “metabolic memory” phenomenon, but the mechanism responsible for this phenomenon is still elusive. Gene expression and biological processes can also be regulated by long noncoding RNAs (LncRNAs), the RNAs with >200 nucleotides and […]

Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure

Am J Physiol Heart Circ Physiol. 2024 Dec 1;327(6):H1327-H1342. doi: 10.1152/ajpheart.00539.2024. Epub 2024 Oct 25. ABSTRACT Diabetes mellitus (DM) is characterized by chronic hyperglycemia, and despite intensive glycemic control, the risk of heart failure in patients with diabetes remains high. Diabetes-induced heart failure (DHF) presents a unique metabolic challenge, driven by significant alterations in cardiac […]

Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity

Liver Int. 2024 Nov 15. doi: 10.1111/liv.16167. Online ahead of print. ABSTRACT BACKGROUND: Drug-induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements. AIMS: Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide. MATERIALS & METHODS: […]

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):30. doi: 10.1167/iovs.65.13.30. ABSTRACT PURPOSE: Localized diseases can be affected by and affect the systemic environment via blood circulation. In this study, we explored the differences in circulating serum mRNAs between patients with wet AMD (wAMD) and controls. METHODS: Blood samples were obtained from 60 Finnish patients with wAMD […]

PCSK7, a potential target for the treatment of age-related macular degeneration: inhibition of retinal epithelial cell death

Int J Clin Exp Pathol. 2024 Oct 15;17(10):371-380. doi: 10.62347/LEHU9944. eCollection 2024. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a complex disease with a pathophysiology that remains incompletely understood. PCSK7 is closely related to the normal development of ocular tissues; however, the roles and mechanisms of PCSK7 in AMD have yet to be elucidated. Therefore, […]

Multiwavelength photobiomodulation in atrophic age-related macular degeneration

Eur J Ophthalmol. 2024 Nov 15:11206721241298316. doi: 10.1177/11206721241298316. Online ahead of print. ABSTRACT PURPOSE: To evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target. METHODS: This retrospective, non-comparative case series […]

HO-1-Mediated Ferroptosis Regulates Retinal Neovascularization via the COX2/VEGFA Axis

Free Radic Biol Med. 2024 Nov 12:S0891-5849(24)01051-7. doi: 10.1016/j.freeradbiomed.2024.11.017. Online ahead of print. ABSTRACT Retinal neovascularization (RNV) is a key pathological process in many blinding disorders. This study aims to investigate the potential mechanisms of heme oxygenase-1 (HO-1) on ferroptosis during RNV. Through bioinformatics analysis, differentially expressed ferroptosis-related genes were identified in the oxygen-induced retinopathy […]