RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy
PLoS One. 2024 Nov 11;19(11):e0313446. doi: 10.1371/journal.pone.0313446. eCollection 2024. ABSTRACT BACKGROUND: Glaucoma, characterized by a high incidence and significant ocular harm, has been elucidated through various mechanisms. Excessive autophagy leading to the loss of retinal ganglion cells (RGCs) is suggested as one potential cause for visual impairment in glaucoma. METHODS: A glaucoma model was established […]
Late-Onset Mitochondrial Neurogastrointestinal Encephalopathy Presenting With Isolated Ophthalmic Findings
J Neuroophthalmol. 2024 Nov 11. doi: 10.1097/WNO.0000000000002287. Online ahead of print. NO ABSTRACT PMID:39527508 | DOI:10.1097/WNO.0000000000002287
Leber Hereditary Optic Neuropathy With Significant Visual Recovery: An MT-ND6 Mutation in a Malay Patient
Cureus. 2024 Oct 10;16(10):e71210. doi: 10.7759/cureus.71210. eCollection 2024 Oct. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare maternally inherited mitochondrial disorder that predominantly affects young men, leading to optic nerve degeneration and subsequent vision loss. The rarity of LHON and its clinical similarity to optic neuritis complicates diagnosis, necessitating genetic testing to confirm specific […]
Structure-Function Correlation in Cobalt-Induced Brain Toxicity
Cells. 2024 Oct 24;13(21):1765. doi: 10.3390/cells13211765. ABSTRACT Cobalt toxicity is difficult to detect and therefore often underdiagnosed. The aim of this study was to explore the pathophysiology of cobalt-induced oxidative stress in the brain and its impact on structure and function. Thirty-five wild-type C57B16 mice received intraperitoneal cobalt chloride injections: a single high dose with […]
Prominin-1 Knockdown Causes RPE Degeneration in a Mouse Model
Cells. 2024 Oct 24;13(21):1761. doi: 10.3390/cells13211761. ABSTRACT There are currently no effective treatments for retinal pigment epithelial (RPE) cell loss in atrophic AMD (aAMD). However, our research on Prominin-1 (Prom1), a known structural protein in photoreceptors (PRs), has revealed its distinct role in RPE and offers promising insights. While pathogenic Prom1 mutations have been linked […]
Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):10. doi: 10.1167/iovs.65.13.10. ABSTRACT PURPOSE: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms […]
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):12. doi: 10.1167/iovs.65.13.12. ABSTRACT PURPOSE: Aging alters the function of the lacrimal gland and disrupts the balance of the microenvironment on the ocular surface, eventually leading to aqueous-tear-deficient dry eye. Mitophagy has been reported to play an important role in aging, but the underlying mechanism remains unclear. METHODS: The […]
The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia
Sci Rep. 2024 Nov 5;14(1):26819. doi: 10.1038/s41598-024-77823-7. ABSTRACT Sperm motility is a crucial factor in male fertility. Photobiomodulation (PBM) has been reported to increase sperm motility, but a consistent approach suitable for identifying standardizable protocols is lacking. We collected asthenozoospermic (n = 70) and normozoospermic (n = 20) semen. The asthenozoospermic samples were irradiated with […]
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen
Aging Dis. 2024 Oct 9. doi: 10.14336/AD.2024.0459. Online ahead of print. ABSTRACT Soft tissue ectopic calcification is due to abnormal accumulation of calcium and phosphate outside the bone. It is the result of the failure of a complex, active, and highly regulated process – much of which is still not well understood. Some of our […]
Cigarette smoke extract induces ferroptosis in human retinal pigment epithelial cells
Heliyon. 2024 Sep 24;10(20):e38151. doi: 10.1016/j.heliyon.2024.e38151. eCollection 2024 Oct 30. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a common blindness diseases. Retinal pigment epithelium (RPE) dysfunction due to smoking is an essential environmental factor in the pathogenesis of AMD. Ferroptosis is a novel type of iron-dependent programmed cell death (PCD). However, the relationship between cigarette […]