MC16 promotes mitochondrial biogenesis and ameliorates acute and diabetic nephropathy
Br J Pharmacol. 2025 Jan 31. doi: 10.1111/bph.17440. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: Kidney disease (KD) is a leading cause of mortality worldwide, affecting 〉10% of the global population. Two of the most common causes of KD are diabetes and acute kidney injury (AKI), both of which induce mitochondrial dysfunction resulting in […]
SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Muller Glial Cell Mitochondrial Fusion and GLAST Expression
Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):62. doi: 10.1167/iovs.66.1.62. ABSTRACT PURPOSE: This study aimed to investigate the role of SIRT4 in retinal protection, specifically its ability to mitigate excitotoxic damage to Müller glial cells through the regulation of mitochondrial dynamics and glutamate transporters (GLASTs). METHODS: A model of retinal excitatory neurotoxicity was established in mice. […]
Research on the function of epigenetic regulation in the inflammation of non-alcoholic fatty liver disease
Life Med. 2024 Aug 31;3(4):lnae030. doi: 10.1093/lifemedi/lnae030. eCollection 2024 Aug. ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition, characterized by a spectrum that progresses from simple hepatic steatosis to nonalcoholic steatohepatitis, which may eventually lead to cirrhosis and hepatocellular carcinoma. The precise pathogenic mechanisms underlying NAFLD and its related metabolic […]
Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury
Sci Rep. 2025 Jan 25;15(1):3193. doi: 10.1038/s41598-025-87300-4. ABSTRACT Spinal cord injury (SCI) is a significant cause of lifelong disability, with no available disease-modifying treatments to promote neuroprotection and axon regeneration after injury. Photobiomodulation (PBM) is a promising therapy which has proven effective at restoring lost function after SCI in pre-clinical models. However, the precise mechanism […]
Metabolic Reprogramming of Neutrophils in the Tumor Microenvironment: Emerging Therapeutic Targets
Cancer Lett. 2025 Jan 23:217466. doi: 10.1016/j.canlet.2025.217466. Online ahead of print. ABSTRACT Neutrophils are pivotal in the immune system and have been recognized as significant contributors to cancer development and progression. These cells undergo metabolic reprogramming in response to various stimulus, including infections, diseases, and the tumor microenvironment (TME). Under normal conditions, neutrophils primarily rely […]
Protocol for real-time assessment of energy metabolism in dissociated mouse retinal photoreceptors using a SeahorseXFe24 analyzer
STAR Protoc. 2025 Jan 23;6(1):103595. doi: 10.1016/j.xpro.2025.103595. Online ahead of print. ABSTRACT Defects in retinal metabolism have been linked to the onset and progression of various retinal diseases. Herein, we provide a protocol for measuring bioenergetics in dissociated mouse retinal photoreceptors. We outline detailed instructions for obtaining morphologically intact and viable photoreceptor cells from adult […]
Mitochondrial transplantation: a promising strategy for the treatment of retinal degenerative diseases
Neural Regen Res. 2024 Dec 7. doi: 10.4103/NRR.NRR-D-24-00851. Online ahead of print. ABSTRACT The retina, a crucial neural tissue, is responsible for transforming light signals into visual information, a process that necessitates a significant amount of energy. Mitochondria, the primary powerhouses of the cell, play an integral role in retinal physiology by fulfilling the high-energy […]
Derivation and Characterization of Isogenic OPA1 Mutant and Control Human Pluripotent Stem Cell Lines
Cells. 2025 Jan 17;14(2):137. doi: 10.3390/cells14020137. ABSTRACT Dominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the OPA1 gene, which encodes a dynamin-related GTPase located to the mitochondrion. OPA1 has been shown to regulate mitochondrial dynamics and promote fusion. Within the mitochondrion, proteolytically processed […]
Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function
bioRxiv [Preprint]. 2025 Jan 2:2024.12.31.630834. doi: 10.1101/2024.12.31.630834. ABSTRACT There are no therapies for reversing chronic organ degeneration. Non-healing degenerative wounds are thought to be irreparable, in part, by the inability of the tissue to respond to reparative stimuli. As such, treatments are typically aimed at slowing tissue degeneration or replacing cells through transplantation. Building on […]
ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells
Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):51. doi: 10.1167/iovs.66.1.51. ABSTRACT PURPOSE: To investigate the effect of Rho-associated protein kinase (ROCK) inhibitor Y27632 on bioenergetic capacity and resilience of corneal endothelial cells (CECs) under metabolic stress. METHODS: Bovine CECs (BCECs) were treated with Y27632 and subjected to bioenergetic profiling using the Seahorse XFp Analyzer. The effects […]