Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):23. doi: 10.1167/iovs.66.4.23. ABSTRACT PURPOSE: Evidence suggests that corneal endothelial cell (CEC) death in Fuchs endothelial corneal dystrophy (FECD) is due to ferroptosis, an iron-mediated cell death. Iron-sulfur cluster (ISC)-containing aconitases and the iron responsive element binding proteins IREBP1 and IREBP2 are known mediators of iron homeostasis. This study […]
Alterations in ganglion cell and nerve fiber layer in Leber hereditary optic neuropathy across clinical stages
BMC Ophthalmol. 2025 Apr 8;25(1):183. doi: 10.1186/s12886-025-03991-3. ABSTRACT PURPOSE: LHON leads to gradual, painless, and permanent vision loss in both eyes, often associated with central scotomas. As the condition progresses, there is a decline in visual function, accompanied by noticeable structural alterations. This study focused on evaluating the clinical characteristics of patients with differing LHON […]
Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):14. doi: 10.1167/iovs.66.4.14. ABSTRACT PURPOSE: Microglial activation plays a pivotal role in the pathogenesis of retinal degeneration, contributing to neuroinflammation within the retina. Previous studies identified that nicotinamide riboside (NR) mitigated light-induced retinal degeneration (LIRD) and inhibited microglial activation. The cGAS-STING signaling pathway has been recognized as a key […]
Adult-Onset Bilateral Optic Neuropathy in a Patient with Non-Familial Childhood-Onset Generalized Dystonia Associated with Mitochondrial DNA 14459G>A Mutation: A Case Report and Review of Literature
Neuroophthalmology. 2024 Sep 17;49(3):206-211. doi: 10.1080/01658107.2024.2405697. eCollection 2025. ABSTRACT The occurrence of Leber Hereditary Optic Neuropathy in association with dystonia is exceedingly rare. There have been only a few previously reported cases describing this clinical phenotype with the mitochondrial DNA 14459 G>A/ND6 mutation. This mutation has been described to also manifest as isolated Leber Hereditary […]
Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis
Neuroscience. 2025 Apr 2:S0306-4522(25)00274-X. doi: 10.1016/j.neuroscience.2025.04.003. Online ahead of print. ABSTRACT Mitochondrial dysfunction has been associated with neurodegenerative diseases (NDDs). This study aimed to explore the association between blood mitochondrial DNA copy number (mtDNA-CN) and development of NDDs. This study was based on two-sample Mendelian randomization (MR) analysis. The genome wide association study (GWAS) data […]
Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis
Front Pharmacol. 2025 Mar 20;16:1571554. doi: 10.3389/fphar.2025.1571554. eCollection 2025. ABSTRACT Retinal cell apoptosis is the primary pathological process in many retinal diseases, including retinitis pigmentosa and age-related macular degeneration, which can cause severe visual impairment and blindness. Lycium barbarum L., a traditional Chinese medicinal botanical drug, has a long history and extensive application in ophthalmic […]
Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration
Res Sq [Preprint]. 2025 Mar 12:rs.3.rs-5989609. doi: 10.21203/rs.3.rs-5989609/v1. ABSTRACT Neuronal function requires high energy expenditure that is likely customized to meet specific signaling demands. However, little is known about diversity of metabolic homeostasis among divergently-functioning types of neurons. To this end, we examined retinal ganglion cells (RGCs), a population of closely related, yet electrophysiologically distinct […]
Corneal epithelial cells upregulate macropinocytosis to engulf metabolically active axonal mitochondria released by injured axons
Ocul Surf. 2025 Apr 1:S1542-0124(25)00051-5. doi: 10.1016/j.jtos.2025.03.007. Online ahead of print. ABSTRACT PURPOSE: To determine the mechanisms used to internalize mitochondria by corneal epithelial cells after in vivo corneal trephine injury and in vitro in corneal epithelial cells. METHODS: Male and female mice were subjected to trephine injury and euthanized immediately, 6, and 24 hours […]
Mitochondrial and Microtubule Defects in Exfoliation Glaucoma
Free Radic Biol Med. 2025 Apr 1:S0891-5849(25)00196-0. doi: 10.1016/j.freeradbiomed.2025.03.046. Online ahead of print. ABSTRACT Exfoliation Syndrome is an age-related systemic condition characterized by large aggregated fibrillar material deposition in the anterior eye tissues. This aggregate formation and deposition on the aqueous humor outflow pathway are significant risk factors for developing Exfoliation Glaucoma (XFG). XFG is […]
Oxygen metabolism abnormalities and high-altitude cerebral edema
Front Immunol. 2025 Mar 19;16:1555910. doi: 10.3389/fimmu.2025.1555910. eCollection 2025. ABSTRACT Hypobaric hypoxia is widely recognized as a prominent risk factor for high-altitude cerebral edema (HACE), which contributes to the exacerbation of multiple pathological mechanisms, including oxidative stress, mitochondrial dysfunction, disruption of blood-;brain barrier integrity, neuroinflammation, and neuronal apoptosis. Among these mechanisms, abnormalities in oxygen metabolism, […]