Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption
Sci Rep. 2025 Jun 4;15(1):19695. doi: 10.1038/s41598-025-05008-x. ABSTRACT Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes. Withaferin A (WA), a bioactive compound from Withania somnifera, has anticancer effects and can modulate cellular processes like autophagy and mitochondrial […]
IRE1-Mediated Endoplasmic Reticulum Stress Response Regulates Oxidative Damage in CYP4V2 Deficient Human Retinal Pigment Epithelial Cells
Biomed J. 2025 Jun 2:100875. doi: 10.1016/j.bj.2025.100875. Online ahead of print. ABSTRACT BACKGROUND: Given the role of polyunsaturated fatty acid (PUFA) overload and mitochondrial dysfunction in retinal pigment epithelium (RPE) cells in causing retinal degeneration in Bietti crystalline dystrophy (BCD), we aimed to identify the pathways responsible for intracellular oxidative stress and mitochondrial damage in […]
Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):17. doi: 10.1167/iovs.66.6.17. ABSTRACT PURPOSE: Primary mitochondrial disorders (PMDs) are a clinically heterogeneous group of genetic disorders that can affect many tissues, with a broad phenotypic spectrum ranging from isolated organ involvement to severe early-onset multisystem disease. Visual loss from optic atrophy is a frequent clinical manifestation of mitochondrial […]
Identification of ER:Melanosome Membrane Contact Sites in the Retinal Pigment Epithelium
Contact (Thousand Oaks). 2025 Jun 2;8:25152564251340949. doi: 10.1177/25152564251340949. eCollection 2025 Jan-Dec. ABSTRACT The retinal pigment epithelium (RPE) forms a monolayer of cells at the blood:retina interface that plays important roles for photoreceptor renewal and function and is central to retinal health. RPE pigment is provided by melanin-containing melanosomes which offer protection against light and oxidative […]
Association between methylmalonic acid and composite dietary antioxidant index and diabetic retinopathy: data from National Health and Nutrition Examination Survey
Nutr Metab (Lond). 2025 Jun 3;22(1):54. doi: 10.1186/s12986-025-00953-w. ABSTRACT BACKGROUND: Oxidative stress and mitochondrial dysfunction play an important role in diabetic retinopathy (DR), and serum methylmalonic acid (MMA) levels are related to oxidative stress and mitochondrial dysfunction. We aimed to explore the impact of MMA levels and the composite dietary antioxidant index (CDAI) on DR […]
Resveratrol inhibits autophagy in cardiomyocytes subjected anoxia/reoxygenation injury: involved in VDAC1/PINK1/Parkin pathway
Toxicol Appl Pharmacol. 2025 May 29:117421. doi: 10.1016/j.taap.2025.117421. Online ahead of print. ABSTRACT Resveratrol has confirmed effectiveness in alleviating myocardial ischemia/reperfusion(I/R) injury. However, the underlying mechanisms remain unclear. Mitochondrial dysfunction in injured cardiomyocytes activates autophagy, and excessive autophagy during reperfusion implicates aggravated injury. Considering that resveratrol preserves mitochondrial function by down-regulating VDAC1 expression, we speculated […]
Amplification of cGAS-STING pathway with “single-molecule multitarget” nanoparticles for chemo-immunotherapy of ovarian cancer
Biomaterials. 2025 May 24;323:123434. doi: 10.1016/j.biomaterials.2025.123434. Online ahead of print. ABSTRACT With a low autoimmune risk and dedicated induction of type Ⅰ interferon production in immunotherapy, “STING therapy” holds broad prospects in the treatment of aggressive and metastatic cancers such as ovarian cancer (OC). Inducing pyroptosis constitutes a promising approach for activating the anti-tumor immune […]
Contrasting pathophysiological mechanisms of OPA1 mutations in autosomal dominant optic atrophy
Cell Death Discov. 2025 May 30;11(1):259. doi: 10.1038/s41420-025-02442-8. ABSTRACT Autosomal dominant optic atrophy (ADOA) caused by mutations in the nuclear-encoded OPA1 gene result in the preferential loss of retinal ganglion cells (RGCs) and progressive optic nerve degeneration. The severity of ADOA can be highly variable. This study compared the pathophysiological consequences of the c.1034 G […]
Chlorogenic acid attenuates oxidative damage in rat lacrimal gland epithelial cells via PI3K/AKT/FoxO3 signaling: network pharmacology and experimental evidence
Sci Rep. 2025 May 30;15(1):19058. doi: 10.1038/s41598-025-02788-0. ABSTRACT Oxidative stress and inflammation are crucial in dry eye pathogenesis. The antioxidant and anti-inflammatory activities of chlorogenic acid (CGA) have been studied in various fields, including ophthalmology. However, its therapeutic effects on dry eye remain unclear. This study aims to predict and validate the mechanisms of CGA […]
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3
Biomed Pharmacother. 2025 May 27;188:118217. doi: 10.1016/j.biopha.2025.118217. Online ahead of print. ABSTRACT Lysine acetylation, tightly regulated by the dynamic balance between lysine acetyltransferases (KATs) and deacetylases (KDACs), plays a critical role in cellular processes, yet its involvement in kidney diseases remains elusive due to inconsistent findings. While KDACs have been extensively studied, the role of […]