Mitochondrial Localization of Antioxidant Nanodrug Suppresses Ocular Inflammation by Alleviating Oxidative Stress on Cells
Chemistry. 2025 Jan 20:e202402441. doi: 10.1002/chem.202402441. Online ahead of print. ABSTRACT External environments (e.g., pollutants, irritants, ultraviolet radiation, etc) probably activate oxidative stress on the ocular surface, further leading to inflammatory responses and cellular apoptosis. For treating ophthalmic diseases, one of the strategies is to regulate oxidative stress through antioxidants. Here we conjugate a polyphenolic […]
Antioxidant MitoQ increases viability of human corneal endothelial cells with congenital hereditary endothelial dystrophy-associated SLC4A11 mutations
Ophthalmic Genet. 2025 Jan 20:1-8. doi: 10.1080/13816810.2025.2450455. Online ahead of print. ABSTRACT PURPOSE: To assess the impact of MitoQ, a mitochondria-targeted antioxidant, on viability of human corneal endothelial cell (hCEnC) lines expressing SLC4A11 mutations associated with congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy type 4 (FECD4). METHODS: SLC4A11 wildtype (SLC4A11WT) and mutant […]
Family and genetic counseling in Leber hereditary optic neuropathy
Ophthalmic Genet. 2025 Jan 20:1-9. doi: 10.1080/13816810.2025.2451175. Online ahead of print. ABSTRACT AIM: Leber hereditary optic neuropathy (LHON) predominantly manifests during adolescence or young adulthood, resulting in sudden and profound vision loss in individuals who previously had normal vision. This abrupt change significantly impacts daily life, necessitating emotional support, counseling and low-vision rehabilitative services to […]
A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots
Front Med (Lausanne). 2025 Jan 6;11:1497446. doi: 10.3389/fmed.2024.1497446. eCollection 2024. ABSTRACT BACKGROUND: Optic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness. Despite its clinical significance and diverse etiological factors, there is currently a lack of comprehensive […]
Glaucomatous retinal ganglion cells: death and protection
Int J Ophthalmol. 2025 Jan 18;18(1):160-167. doi: 10.18240/ijo.2025.01.20. eCollection 2025. ABSTRACT Glaucoma is a group of diseases characterized by progressive optic nerve degeneration, with the characteristic pathological change being death of retinal ganglion cells (RGCs), which ultimately causes visual field loss and irreversible blindness. Elevated intraocular pressure (IOP) remains the most important risk factor for […]
A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti-Inflammatory Effects in the Treatment of Dry Eye Disease
Adv Healthc Mater. 2025 Jan 19:e2404372. doi: 10.1002/adhm.202404372. Online ahead of print. ABSTRACT Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes a substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), is a critical factor perpetuating the inflammatory […]
Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury
Neural Regen Res. 2025 Jan 13. doi: 10.4103/NRR.NRR-D-24-00674. Online ahead of print. ABSTRACT Ischemia-reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis is a newly defined integral form of regulated cell death that combines the key features of pyroptosis, apoptosis, and necroptosis. Oligomerization of mitochondrial voltage-dependent anion channel 1 is an important pathological […]
Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease
Neural Regen Res. 2025 Jan 13. doi: 10.4103/NRR.NRR-D-24-00764. Online ahead of print. ABSTRACT The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of disease-modifying treatments. The glymphatic system, a recently identified […]
Mitochondria-Targeted Antioxidant (MitoQ) and Nontargeted Antioxidant (Idebenone) Mitigate Mitochondrial Dysfunction in Corneal Endothelial Cells
Cornea. 2025 Jan 17. doi: 10.1097/ICO.0000000000003801. Online ahead of print. ABSTRACT PURPOSE: To investigate the effectiveness of mitochondrial-targeted antioxidant mitoquinone (MitoQ) and nontargeted antioxidant idebenone (Idb) in alleviating mitochondrial dysfunction in corneal endothelial cells (CEnCs). METHODS: In vitro experiments were conducted using immortalized normal human corneal endothelial cells (HCEnC-21T; SVN1-67F) and Fuchs endothelial corneal dystrophy […]
Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function
Hypertension. 2025 Jan 16. doi: 10.1161/HYPERTENSIONAHA.124.23666. Online ahead of print. ABSTRACT BACKGROUND: Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure and fluid balance. However, the specific involvement of AM2 in cardiac hypertrophy has not been comprehensively elucidated, warranting further investigation into its molecular mechanisms and therapeutic implications. METHODS: Cardiac hypertrophy was induced in […]