Less Is More: The RPE Cell Culture Medium Additive THT Mildly Impairs RPE Health
Adv Exp Med Biol. 2025;1468:333-337. doi: 10.1007/978-3-031-76550-6_55. ABSTRACT THT is an additive for culture medium used to maintain retinal pigment epithelial (RPE) cells. The individual components of THT are taurine, hydrocortisone, and triiodothyronine. The effects of THT on RPE health had not been defined. To determine how THT affects RPE cell physiology, we grew induced […]
Ocular Tissue-Specific Amino Acid Metabolism in Gyrate Atrophy
Adv Exp Med Biol. 2025;1468:279-284. doi: 10.1007/978-3-031-76550-6_46. ABSTRACT Deficiency of the mitochondrial enzyme ornithine aminotransferase (OAT) causes gyrate atrophy of the choroid and retina (GACR), a rare autosomal inherited disorder characterized by a substantial elevation in plasma ornithine and progressive chorioretinal degeneration. While OAT is expressed in many tissues, the deficiency mainly affects the retinal […]
Potential Role of NUR77 in the Aging Retinal Pigment Epithelium and Age-Related Macular Degeneration
Adv Exp Med Biol. 2025;1468:165-169. doi: 10.1007/978-3-031-76550-6_27. ABSTRACT The underlying mechanisms associated with age-related changes in the morphology and function of retinal pigmented epithelial (RPE) cells are poorly understood. The aging RPE progresses through several structural changes including loss of melanin granules, accumulation of lipofuscin, and cytoskeletal changes, among others. Extracellular to it, there is […]
An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy
Sci Rep. 2025 Feb 9;15(1):4829. doi: 10.1038/s41598-025-89076-z. ABSTRACT Electrical stimulation (ES) may be effective for intractable retinal or optic nerve diseases. We studied frequent transcutaneous ES in a single-center, single-arm prospective study in patients with Leber hereditary optic neuropathy (LHON) who carry the mitochondrial (mt) 11778 G > A mutation. A 30-min ES was applied […]
Hydroxytyrosol downregulates inflammatory responses via Nrf2/HO-1 axis during fungal keratitis and exerts antifungal effects
Int Immunopharmacol. 2025 Feb 6;149:114202. doi: 10.1016/j.intimp.2025.114202. Online ahead of print. ABSTRACT PURPOSE: This study aims to explore the protective effect and underlying mechanism of hydroxytyrosol (HT) in fungal keratitis. METHODS: Mouse models with Aspergillus fumigatus (A. fumigatus) keratitis, human corneal epithelial cells (HCECs) and RAW 264.7 cells were used in this study. Methods employed […]
Exogenous hydrogen sulfide and NOX2 inhibition mitigate ferroptosis in pressure-induced retinal ganglion cell damage
Biochim Biophys Acta Mol Basis Dis. 2025 Feb 4:167705. doi: 10.1016/j.bbadis.2025.167705. Online ahead of print. ABSTRACT Glaucoma, a primary cause of irreversible blindness, is characterized by the progressive degeneration of retinal ganglion cells (RGCs). While elevated intraocular pressure (IOP) significantly contributes to disease progression, managing IOP alone does not completely halt it. The mechanisms underlying […]
Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration
Eur J Med Res. 2025 Feb 5;30(1):81. doi: 10.1186/s40001-025-02315-x. ABSTRACT OBJECTIVES: This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells. METHODS: Six autophagy related targets were selected for molecular docking […]
A Case of Leber’s Hereditary Optic Neuropathy With Reversible Symmetric Lesions in the Substantia Nigra
Cureus. 2025 Jan 3;17(1):e76883. doi: 10.7759/cureus.76883. eCollection 2025 Jan. ABSTRACT A 34-year-old man with a history of alcoholism experienced progressive vision loss in both eyes over two months. His best corrected visual acuity was 0.1 OD and 0.2 OS, with visual field tests showing central scotoma bilaterally. Fundus examination revealed reddish optic discs with peripapillary […]
An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine
EMBO Mol Med. 2025 Feb 3. doi: 10.1038/s44321-025-00194-7. Online ahead of print. ABSTRACT Esophagitis is a frequent, but at the molecular level poorly characterized condition with diverse underlying etiologies and treatments. Correct diagnosis can be challenging due to partially overlapping histological features. By proteomic profiling of routine diagnostic FFPE biopsy specimens (n = 55) representing […]
Leber Hereditary Optic Neuropathy: Support, Genetic Prediction and Accurate Genetic Counselling Enhance Family Planning Choices
Clin Exp Ophthalmol. 2025 Feb 2. doi: 10.1111/ceo.14493. Online ahead of print. ABSTRACT With the increased availability of genetic testing and the addition of mitochondrial genetic variants on disease panels, accurate genetic counselling for individuals and families affected by, or at risk of, Leber hereditary optic neuropathy (LHON) is becoming increasingly relevant. Challenges in providing […]