Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in experimental Alzheimer’s disease model
Cell Mol Biol (Noisy-le-grand). 2025 Apr 15;71(3):117-123. doi: 10.14715/cmb/2025.71.3.14. ABSTRACT This study investigates the effects of regular exercise on inflammation and mitochondrial biogenesis in the eye using a controlled experimental Alzheimer’s disease (AD) model. Twenty-four male Wistar rats were divided into four groups: control, Alzheimer, exercise, and Alzheimer with exercise. Molecular markers, including Nuclear Factor […]
The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study
Sci Rep. 2025 Apr 15;15(1):12928. doi: 10.1038/s41598-025-97722-9. ABSTRACT Myopia, a major cause of irreversible visual impairment globally, is projected to affect about 25% of the world’s population by 2025. Myopia progresses through childhood and adolescence, necessitating frequent prescription updates. While genetic and environmental factors are well-established contributors to myopia, emerging evidence suggests a significant role […]
Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):36. doi: 10.1167/iovs.66.4.36. ABSTRACT PURPOSE: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal endothelial dystrophy and guttae are crucial in causing progressive loss of corneal endothelium. This study aimed to find a way to inhibit the formation of guttae in FECD. METHODS AND RESULTS: Mitochondria fatty acid […]
Maculopathy after long-term use of fondaparinux, a heparin mimetic and heparanase inhibitor
Am J Ophthalmol Case Rep. 2025 Mar 22;38:102308. doi: 10.1016/j.ajoc.2025.102308. eCollection 2025 Jun. ABSTRACT PURPOSE: To report maculopathy associated with the long-term use of fondaparinux, a heparin mimetic and inhibitor of the extracellular matrix enzyme, heparanase. OBSERVATIONS: A 41-year-old woman receiving thrice weekly injections of fondaparinux as prophylaxis against deep vein thrombosis for 9 years […]
Ameliorating effect of the aldose reductase inhibitor 1-Acetyl-5-phenyl-1 H-pyrrol-3-ylacetate on galactose-induced cataract
Sci Rep. 2025 Apr 14;15(1):12759. doi: 10.1038/s41598-025-98079-9. ABSTRACT Diabetes mellitus, as a common chronic disease, easily leads to significant changes in the structure of the eye, among which diabetic cataract is particularly common. Although surgery is the main treatment for this complication, it may be accompanied by postoperative complications. Therefore, it is particularly important to […]
Overcoming radiation-induced PD-L1 and COX-2 upregulation by nitric oxide gas nanogenerator to sensitize radiotherapy of lung cancer
Biomaterials. 2025 Apr 10;321:123335. doi: 10.1016/j.biomaterials.2025.123335. Online ahead of print. ABSTRACT Currently, certain lung cancer patients exhibit resistance to radiotherapy due to reduced DNA damage under hypoxic conditions and the cytoprotective and immune-resistance effect caused by increased programmed death ligand-1 (PD-L1) and Cyclooxygenase 2 (COX-2) expression after radiotherapy. At present, existing nanoparticles or drugs could […]
Infantile Cerebellar-Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model
Clin Genet. 2025 Apr 10. doi: 10.1111/cge.14745. Online ahead of print. ABSTRACT Infantile Cerebellar-Retinal Degeneration (ICRD) is an autosomal recessive neuro-disability associated with hypotonia, seizures, optic atrophy, and retinal degeneration. Recessive variants of the mitochondrial aconitase gene (ACO2) are a known cause of ICRD. Here, we present a paediatric male patient with ICRD, where whole […]
Corrigendum to “Genetic Analysis and multimodal imaging confirm m.12148 T>C mitochondrial variant pathogenicity leading to multisystem dysfunction” [Molecular Genetics and Metabolism 144 (2025); 109049]
Mol Genet Metab. 2025 Apr 9:109100. doi: 10.1016/j.ymgme.2025.109100. Online ahead of print. NO ABSTRACT PMID:40210567 | DOI:10.1016/j.ymgme.2025.109100
Intraretinal variation in disease severity in the Oatrhg mouse model of gyrate atrophy
Exp Eye Res. 2025 Apr 8:110382. doi: 10.1016/j.exer.2025.110382. Online ahead of print. ABSTRACT Gyrate atrophy is an autosomal recessive retinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT), a mitochondrial enzyme required for ornithine degradation. Deficiency of OAT leads to hyperornithinemia and progressive chorioretinal atrophy that results in permanent vision loss. […]
Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation
J Enzyme Inhib Med Chem. 2025 Dec;40(1):2472817. doi: 10.1080/14756366.2025.2472817. Epub 2025 Apr 10. ABSTRACT ER carboxylesterase 1A (CES1A) is an important metabolic enzyme involved in lipid metabolism. Targeting the CES1A is a promising approach for diseases associated with disorders of lipid metabolism therapy. In this study, screening of 26 natural lignans, three of them were […]