Disrupted Mitochondrial Dynamics Impair Corneal Epithelial Healing in Neurotrophic Keratopathy
Int J Mol Sci. 2025 Feb 3;26(3):1290. doi: 10.3390/ijms26031290. ABSTRACT Neurotrophic keratopathy (NK) is a degenerative corneal disease characterized by impaired corneal sensitivity and epithelial repair that is often linked to sensory nerve dysfunction. To establish a clinically relevant model and explore the mechanisms underlying NK pathogenesis, we developed a novel mouse model through partial […]
The Role of Visual Electrophysiology in Systemic Hereditary Syndromes
Int J Mol Sci. 2025 Jan 23;26(3):957. doi: 10.3390/ijms26030957. ABSTRACT Visual electrophysiology is a valuable tool for evaluating the visual system in various systemic syndromes. This review highlights its clinical application in a selection of syndromes associated with hearing loss, mitochondrial dysfunction, obesity, and other multisystem disorders. Techniques such as full-field electroretinography (ffERG), multifocal electroretinography […]
Endoplasmic Reticulum-Mitochondria Crosstalk in Fuchs Endothelial Corneal Dystrophy: Current Status and Future Prospects
Int J Mol Sci. 2025 Jan 22;26(3):894. doi: 10.3390/ijms26030894. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is a progressive and debilitating disorder of the corneal endothelium (CE) that affects approximately 4% of individuals over the age of 40. Despite the burden of the disease, the pathogenesis of FECD remains poorly understood, and treatment options are limited, […]
Enhancing the Photocatalytic Efficacy of g-C3N4 Through Irradiation Modification and Composite Construction with Ti3C2 for Photodynamic Therapy
Molecules. 2025 Jan 22;30(3):487. doi: 10.3390/molecules30030487. ABSTRACT Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (Ti3C2, TC)/graphitic carbon nitride (g-C3N4, CN) nanocomposite through a synergistic approach combining electron beam irradiation and 2D/2D composite formation. […]
Metabolic dysregulation in glaucoma
Clin Exp Optom. 2025 Feb 12:1-7. doi: 10.1080/08164622.2025.2463502. Online ahead of print. ABSTRACT Glaucoma is a multifactorial neurodegenerative disorder characterised by the progressive loss of retinal ganglion cells, ultimately leading to irreversible blindness worldwide. Recent research highlights metabolic dysregulation as a crucial factor in the pathophysiology of glaucoma. This review examines the intricate relationship between […]
Mitochondrial Dysfunction During TGF-beta1-Induced Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells
Curr Eye Res. 2025 Feb 12:1-9. doi: 10.1080/02713683.2025.2464783. Online ahead of print. ABSTRACT PURPOSE: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells contributes to the epiretinal membrane development in proliferative vitreoretinopathy (PVR). This study aimed at investigating changes in mitochondrial function during EMT in PVR. METHODS: Transmission electron microscopy (TEM) was utilized to examine […]
An artificial intelligence and blockchain technology-based data management framework for multicenter randomized controlled trials
Sci Bull (Beijing). 2025 Jan 25:S2095-9273(25)00120-3. doi: 10.1016/j.scib.2025.01.041. Online ahead of print. NO ABSTRACT PMID:39933985 | DOI:10.1016/j.scib.2025.01.041
FXR suppress Müller cell activation by regulating cGAS/STING pathway in diabetic retinopathy
FEBS J. 2025 Feb 11. doi: 10.1111/febs.17421. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is widely acknowledged as an ocular complication of diabetes mellitus involving retinal inflammation and secondary neuro/microvascular degeneration. Müller glial cells play a crucial role in regulating retinal homeostasis and neuroinflammation within the retina. Farnesoid X nuclear receptor (FXR) has emerged […]
Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6-/- Retinal Organoids
Adv Exp Med Biol. 2025;1468:401-407. doi: 10.1007/978-3-031-76550-6_66. ABSTRACT ATF6 is a key regulator of the unfolded protein response (UPR) pathway that maintains cellular homeostasis during ER stress. In people, loss of ATF6 function causes cone dysfunction, manifesting as achromatopsia (ACHM). Previously, we generated ACHM retinal organoids (ROs) from patient induced pluripotent stem cells (iPSCs) carrying […]
Mitochondrial DNA Damage in the Retinal Pigmented Epithelium (RPE) and Its Role in RPE Pathobiology
Adv Exp Med Biol. 2025;1468:375-379. doi: 10.1007/978-3-031-76550-6_62. ABSTRACT Retinal pigmented epithelial (RPE) cells have critical functions in the retina. These cells rely heavily on their mitochondria to generate energy, offer metabolites for biosynthesis through the TCA cycle, regulate apoptosis, and process lipids from photoreceptors. Therefore, mitochondrial damage has significant consequences for the RPE and, by […]