Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis
Theranostics. 2025 Apr 9;15(11):5087-5105. doi: 10.7150/thno.105299. eCollection 2025. ABSTRACT Rationale: Pathological retinal angiogenesis with irregular and fragile vessels (also termed neovascularization, a response to hypoxia and dysmetabolism) is a leading cause of vision loss in all age groups. This process is driven in part through the energy deficiency in retinal neurons. Sustaining neural retinal metabolism […]
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer
Theranostics. 2025 Apr 13;15(11):5499-5517. doi: 10.7150/thno.113741. eCollection 2025. ABSTRACT Background: The disruption of mitochondrial homeostasis in acute kidney injury (AKI) is an important factor that drives persistent renal dysfunction. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown great therapeutic potential in AKI, but insufficient specificity of targeting the impaired mitochondrial function. Herein, we developed an […]
Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in Mice
Aging Cell. 2025 Apr 28:e70081. doi: 10.1111/acel.70081. Online ahead of print. ABSTRACT Age is a primary risk factor for chronic conditions, including age-related macular degeneration (AMD). Impairments in autophagy processes are implicated in AMD progression, but the extent of autophagy’s contribution and its therapeutic potential remain ambiguous. This study investigated age-associated transcriptomic changes in autophagy […]
Mitochondria-Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function
Contact (Thousand Oaks). 2025 Apr 13;8:25152564251332141. doi: 10.1177/25152564251332141. eCollection 2025 Jan-Dec. ABSTRACT Sites of close apposition between organelles, known as membrane contact sites (MCSs), are critical regulators of organelle function. Mitochondria form elaborate reticular networks that perform essential metabolic and signaling functions. Many mitochondrial functions are regulated by MCSs formed between mitochondria and other organelles. […]
Targeting mitochondrial DNA-STING-NF-kappaB Axis-mediated microglia activation by cryptotanshinone alleviates ischemic retinopathy
Phytomedicine. 2025 Apr 18;142:156779. doi: 10.1016/j.phymed.2025.156779. Online ahead of print. ABSTRACT BACKGROUND: Ischemic retinopathy, a leading cause of vision impairment, involves oxidative stress and dysregulated inflammation, with microglia playing a key role. Cryptotanshinone (CTS), a bioactive compound from Salvia miltiorrhiza, exhibits anti-inflammatory and antioxidant properties and thus has the potential for development as a therapeutic […]
In Vitro Toxicity of Cetalkonium Chloride on Corneal Epithelial Cells
Pharmaceutics. 2025 Apr 16;17(4):522. doi: 10.3390/pharmaceutics17040522. ABSTRACT Objective: To investigate the toxicity of cetalkonium chloride (CKC) on primary cultured human corneal epithelial cells (HCECs). Methods: HCECs were subjected to various concentrations (0.03125 × 10-4 to 2.0 × 10-4% (w/v)) of CKC for durations ranging from 24 to 72 h. Cell viability was evaluated using the […]
MDL800, a SIRT6 activator, mitigates neuroinflammation-induced retinal damage by modulating microglial M1/M2 polarization in experimental glaucoma
Cell Signal. 2025 Apr 22:111832. doi: 10.1016/j.cellsig.2025.111832. Online ahead of print. ABSTRACT PURPOSE: Glaucoma is a group of irreversible neurodegenerative disorders of the optic nerve, characterized by distinct optic nerve damage and progressive visual field loss, with its pathological foundation involving the apoptosis of retinal ganglion cells (RGCs) and axonal degeneration. Neuroinflammation driven by the […]
Piperine and its nanoformulations: A mechanistic review of their anti-cancer activities
Biomed Pharmacother. 2025 Apr 23;187:118075. doi: 10.1016/j.biopha.2025.118075. Online ahead of print. ABSTRACT Piperine, an active compound found in black pepper, exhibits promising anti-cancer properties by targeting critical signaling pathways involved in cancer cell proliferation, migration, and invasion. This review explores the diverse mechanisms through which piperine exerts its effects, including inhibition of the PI3K/Akt/mTOR and […]
OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation
J Transl Med. 2025 Apr 24;23(1):471. doi: 10.1186/s12967-025-06471-w. ABSTRACT BACKGROUND: Autosomal dominant optic atrophy (ADOA), a leading common inherited optic neuropathy, arises from progressive retinal ganglion cell degeneration, often linked to OPA1 mutations. OPA1, a mitochondrial GTPase, regulates mitochondrial fusion, crista structure, and apoptosis. While GTPase-related dysfunction is well-studied, the role of other OPA1 domains […]
Advances in origin, evolution, and pathogenesis of optic disc drusen: A narrative review
Indian J Ophthalmol. 2025 May 1;73(5):637-647. doi: 10.4103/IJO.IJO_937_24. Epub 2025 Apr 24. ABSTRACT Optic disc drusen (ODD) is acellular calcified deposits found mainly in front of the lamina cribrosa within the optic nerve. It can cause chronic or acute vision loss. There has been progress in clinical diagnosis using ophthalmic multimodal imaging in recent years. […]