Innovative technologies for the treatment of dry age-related macular degeneration (AMD) – modern therapeutic perspectives and their future
Rom J Ophthalmol. 2025 Jan-Mar;69(1):10-16. doi: 10.22336/rjo.2025.03. ABSTRACT PURPOSE: This review explores modern therapeutic options for the dry form of age-related macular degeneration (AMD), a condition representing one of the most significant challenges in ophthalmology due to its progressive nature and lack of effective treatment. The study discusses innovative approaches, evaluates available methods, and examines […]
Isoquercetin Alleviates Diabetic Retinopathy Via Inhibiting p53-Mediated Ferroptosis
Cell Biol Int. 2025 May 7. doi: 10.1002/cbin.70027. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a retinal vasculopathy stemming from diabetes mellitus, characterized by microvascular changes in the retina that can lead to visual impairment or even blindness. Ferroptosis, a form of regulated cell death driven by iron accumulation and lipid peroxidation, has […]
DNA methyltransferase 1 modulates mitochondrial function through bridging m(5)C RNA methylation
Mol Cell. 2025 Apr 30:S1097-2765(25)00361-2. doi: 10.1016/j.molcel.2025.04.019. Online ahead of print. ABSTRACT DNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) disorder. Here, we demonstrated that DNMT1 has the […]
A Spontaneous Nonhuman Primate Model of Inherited Retinal Degeneration
JCI Insight. 2025 May 6:e190807. doi: 10.1172/jci.insight.190807. Online ahead of print. ABSTRACT Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases in particular are significant in their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform macular dystrophy (BVMD), caused by variants […]
Poldip2 aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway
Life Sci. 2025 May 2:123681. doi: 10.1016/j.lfs.2025.123681. Online ahead of print. ABSTRACT BACKGROUND AND AIM: Inflammation is a crucial aspect of the pathophysiology of diabetic retinopathy (DR). Polymerase delta-interacting protein 2 (Poldip2) has been linked to inflammation in various disorders, but its role in DR remains unclear. This study aims to elucidate the underlying mechanisms […]
Metal-phenolic epigallocatechin gallate‑zinc antioxidant nanoparticles for cataract treatment
J Control Release. 2025 May 2:113798. doi: 10.1016/j.jconrel.2025.113798. Online ahead of print. ABSTRACT In cataract, oxidative stress plays an important role. It breaks the balance of the antioxidant defense system by destroying biological macromolecules such as proteins, lipids and nucleic acids in the lens, induces lens opacity, and then leads to the formation of cataract. […]
Valine acts as an early biomarker and exacerbates pathological cardiac hypertrophy by impairing mitochondrial quality control
Atherosclerosis. 2025 Apr 26;405:119216. doi: 10.1016/j.atherosclerosis.2025.119216. Online ahead of print. ABSTRACT OBJECTIVE: Pathological cardiac hypertrophy is an independent risk factor for heart failure (HF). Early identification and timely treatment are crucial for significantly delaying the progression of HF. METHODS: Targeted amino acid metabolomics and RNA sequencing (RNA-seq) were combined to explore the underlying mechanism. In […]
Chlamydia trachomatis infection induces ferroptosis and enhances chlamydial replication
Microb Pathog. 2025 Apr 30:107656. doi: 10.1016/j.micpath.2025.107656. Online ahead of print. ABSTRACT Chlamydia trachomatis (C. trachomatis) has been shown to activate multiple programmed cell death pathways, which contribute significantly to host immune responses. Nevertheless, the precise molecular mechanisms by which C. trachomatis induces cell death remain poorly characterized. Ferroptosis, a recently identified form of iron-dependent, […]
Angiotensinogen inhibition concurrently mitigates alcohol-associated hepatic and muscle injury
Metabolism. 2025 Apr 29:156275. doi: 10.1016/j.metabol.2025.156275. Online ahead of print. ABSTRACT AIMS: The organ communication mechanisms driven by alcohol-associated liver disease (ALD) remain inadequately understood. This study explores the endocrine roles of the hepatokine angiotensinogen (AGT) and the renin-angiotensin system (RAS) in ALD. METHODS AND RESULTS: Hepatokine screening tests revealed that chronic-binge ethanol consumption upregulates […]
Ursolic acid induces apoptosis in nasopharyngeal carcinoma cells through the P53 signaling pathway: a network pharmacology and experimental validation study
Med Oncol. 2025 May 1;42(6):189. doi: 10.1007/s12032-025-02749-7. ABSTRACT Nasopharyngeal carcinoma (NPC) is a malignant neoplasm that is highly prevalent in East Asia and presents significant therapeutic challenges due to limited treatment options and severe adverse effects. Ursolic acid (UA) is a pentacyclic triterpenoid with anticancer activity in various tumors; however, its mechanism of action in […]