Calcium (Ca(2+)) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS)
NPJ Aging. 2025 Feb 21;11(1):11. doi: 10.1038/s41514-025-00197-1. ABSTRACT Therapy-induced senescence (TIS) alters calcium (Ca²⁺) flux and Mitochondria-ER Contact Sites (MERCS), revealing critical vulnerabilities in senescent cells. In this study, TIS was induced using Doxorubicin and Etoposide, resulting in an increased MERCS contact surface but a significant reduction in ER-mitochondria Ca²⁺ flux. Mechanistically, TIS cells exhibit […]
Leber Hereditary Optic Neuropathy “Plus” with the m.14487 T>C Mutation as the Causality of Hemidystonia: A Case Report
Case Rep Ophthalmol. 2024 Nov 13;15(1):852-858. doi: 10.1159/000542202. eCollection 2024 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) complicated with extraocular symptoms is called LHON plus. We describe a case of LHON plus with a rare mutation, which also caused dystonia. CASE PRESENTATION: An 18-year-old male patient developed symptoms of dystonia at the age of […]
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Feb 18:159600. doi: 10.1016/j.bbalip.2025.159600. Online ahead of print. ABSTRACT BCO2 (β-carotene oxygenase 2) converts carotenoids into apocarotenoids by oxidative cleavage across double bonds and controls carotenoid homeostasis in vertebrate tissues. In this study, we examined BCO2’s expression, localization, and activity in human cell lines and the retina. […]
Mechanisms of astrocyte aging in reactivity and disease
Mol Neurodegener. 2025 Feb 21;20(1):21. doi: 10.1186/s13024-025-00810-7. ABSTRACT Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organisms age. Here, we examine the transcriptional, cell biology, and functional differences in astrocytes across normal aging. […]
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration
Nat Commun. 2025 Feb 20;16(1):1789. doi: 10.1038/s41467-025-57135-8. ABSTRACT Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, and the molecular mechanisms underlying neurodegeneration are unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset neurodegeneration of retinal ganglion cells (RGCs), optic nerve […]
Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):51. doi: 10.1167/iovs.66.2.51. ABSTRACT PURPOSE: As a consequence of the natural aging process, the lacrimal glands may become dysfunctional. The present study aimed to investigate the potential role of melatonin (MLT) in the alleviation of age-related lacrimal gland dysfunction and to elucidate the underlying mechanism. METHODS: In this study, […]
CSF IL-6, GDF-15, GFAP and NfL levels in early Alzheimer disease: a pilot study
Ther Adv Neurol Disord. 2025 Feb 19;18:17562864251314773. doi: 10.1177/17562864251314773. eCollection 2025. ABSTRACT BACKGROUND: Despite their potential usefulness as biomarkers, no study has investigated the interactions between cerebrospinal fluid (CSF) changes of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), growth differentiation factor 15 (GDF-15), transactive response DNA binding protein (TDP-43) and interleukin-6 (IL-6) and […]
Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression
Sci Rep. 2025 Feb 18;15(1):5927. doi: 10.1038/s41598-025-89081-2. ABSTRACT Mitochondria absorb short wavelengths around 420 nm. This is associated with reduced ATP and restricted mobility. The 420-450 nm range is a significant element of LED lighting and computer monitors. Here we expose freely moving mice to 420-450 nm lighting and show rapidly weight gain within a […]
Leber’s hereditary optic neuropathy – current status of idebenone and gene replacement therapies
Med Genet. 2025 Feb 12;37(1):57-63. doi: 10.1515/medgen-2024-2066. eCollection 2025 Apr. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is the most common mitochondrial disease, and was the first to be linked to mitochondrial DNA (mtDNA) variations. Recently, autosomal recessive forms of LHON were described in addition to the classical mtDNA-associated forms. Clinically, LHON manifests with subacute and […]
Sustained release of a novel non-fibrate PPARα agonist from microparticles for neuroprotection in murine models of age-related macular degeneration
J Control Release. 2025 Feb 15:S0168-3659(25)00150-6. doi: 10.1016/j.jconrel.2025.02.037. Online ahead of print. ABSTRACT Prior research has demonstrated the therapeutic potential of peroxisome proliferator-activated receptor α (PPARα) agonist fenofibrate on diabetic retinopathy. In the present study, a novel non-fibrate PPARα agonist, A190, was designed with higher potency and selectivity than fenofibrate in PPARα agonism. A190 was […]