Microwave-Responsive AlEu-MOFs Potentiate NLRP3-Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave-Immunotherapy
Small. 2025 May 9:e2501157. doi: 10.1002/smll.202501157. Online ahead of print. ABSTRACT Microwave thermotherapy is favored in clinical practice for breast cancer conservation strategies due to its minimally invasive characteristic. Nevertheless, the immunosuppressive tumor microenvironment (TME) significantly attenuates the therapeutic efficacy of anti-tumor immune response, posing challenges in effectively preventing tumor recurrence and metastasis. Pyroptosis, a […]
Recurrent Optic Neuritis as a Misleading Presentation of Leber Hereditary Optic Neuropathy: The Need for High Clinical Suspicion in Young Men
Cureus. 2025 Apr 8;17(4):e81863. doi: 10.7759/cureus.81863. eCollection 2025 Apr. ABSTRACT A 29-year-old Chinese gentleman presented with acute-onset right eye (RE) central scotoma and blurring of vision. Upon presentation, RE visual acuity (VA) was 6/30. The RE optic disc (OD) was mildly swollen, but other findings were unremarkable. A computed tomography (CT) imaging study showed no […]
MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway
Cell Death Discov. 2025 May 8;11(1):226. doi: 10.1038/s41420-025-02439-3. ABSTRACT Diabetic retinopathy (DR) ranks among the primary causes of adult blindness globally. Oxidative stress and mitochondrial dysfunction play a critical role in the progression of DR. Mounting data indicated that small extracellular vesicles (sEVs) of mesenchymal stem cell (MSC) have the ability to transport bioactive chemicals […]
Corrigendum to “In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics” [Mitochondrion 22 (2015) 1-8]
Mitochondrion. 2025 May 7:102044. doi: 10.1016/j.mito.2025.102044. Online ahead of print. NO ABSTRACT PMID:40340170 | DOI:10.1016/j.mito.2025.102044
Fenofibrate inhibits activation of cGAS-STING pathway by alleviating mitochondrial damage to attenuate inflammatory response in diabetic dry eye
Free Radic Biol Med. 2025 May 6:S0891-5849(25)00658-6. doi: 10.1016/j.freeradbiomed.2025.05.383. Online ahead of print. ABSTRACT The cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes (STING) signaling pathway are critical regulators of inflammation. This study aims to investigate the role of the cGAS-STING signaling pathway in diabetic dry eye disease (DDE) and further explore the therapeutic […]
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis
Antioxidants (Basel). 2025 Mar 19;14(3):363. doi: 10.3390/antiox14030363. ABSTRACT The disruption of microglial homeostasis and cytokine release are critical for neuroinflammation post-injury and strongly implicated in retinal neurodegenerative diseases like glaucoma. This study examines microglial responses to chemical hypoxia induced by cobalt chloride (CoCl2) in BV-2 murine microglial cells, focusing on signaling pathways and proteomic alterations. […]
Cyclic cell-penetrating peptide-engineered ceria nanoparticles for non-invasive alleviation of ultraviolet radiation-induced cataract
J Nanobiotechnology. 2025 May 7;23(1):337. doi: 10.1186/s12951-025-03402-1. ABSTRACT Oxidative stress, which results from the accumulation of free radicals, plays a substantial role in cataract formation. Antioxidants have shown promise in mitigating or even preventing this process. However, delivering antioxidants noninvasively to the anterior segment of the eye has been a significant challenge. In this study, […]
miR142 silencing alleviates retinal inflammation by impairing mitochondrial function and reprogramming metabolism of CD4(+) T cells via targeting MTFR1
Int Immunopharmacol. 2025 May 6;157:114727. doi: 10.1016/j.intimp.2025.114727. Online ahead of print. ABSTRACT BACKGROUND: Autoimmune uveitis is a sight-threatening inflammatory disease of the retina. MicroRNA-142 (miR-142) has been implicated in its pathogenesis. This study aimed to elucidate the role of miR-142 in uveitis and its underlying mechanisms. METHODS: The expression of miR-142-3p was analyzed in peripheral […]
cGAS-STING-NFκB pathway plays a role in burn injury-induced muscle wasting
Shock. 2025 Apr 28. doi: 10.1097/SHK.0000000000002613. Online ahead of print. ABSTRACT BACKGROUND: Muscle wasting (MW) is a ubiquitous and debilitating consequence of major burn injury (BI), leading to both short- and long-term health complications. The cGAS-STING-NFκB pathway is a key mediator of inflammatory responses triggered by infection, cellular stress, and tissue damage. This study investigated […]
Isolated and Syndromic Genetic Optic Neuropathies: A Review of Genetic and Phenotypic Heterogeneity
Int J Mol Sci. 2025 Apr 20;26(8):3892. doi: 10.3390/ijms26083892. ABSTRACT Nonsyndromic and syndromic hereditary optic neuropathies (HONs) encompass a variety of genetic illnesses that cause progressive optic nerve damage, resulting in considerable vision impairment. These disorders result from pathogenic variants in mitochondrial or nuclear DNA, impacting essential cellular processes like oxidative phosphorylation, mitochondrial dynamics, and […]