Exploring the role of mitochondrial dysfunction and aging in COVID-19-Related neurological complications
Mol Biol Rep. 2025 May 21;52(1):479. doi: 10.1007/s11033-025-10586-0. ABSTRACT The COVID-19 pandemic, caused by SARS-CoV-2, posed a tremendous challenge to healthcare systems globally. Severe COVID-19 infection was reported to be associated with altered immunometabolism and cytokine storms, contributing to poor clinical outcomes and in many cases resulting in mortality. Despite promising preclinical results, many drugs […]
Lipid-sensor FFAR1 curbs autophagy and mitochondrial respiration in murine retinal angiomatous proliferation
Autophagy Rep. 2023 Feb 21;2(1):2177932. doi: 10.1080/27694127.2023.2177932. eCollection 2023. NO ABSTRACT PMID:40395299 | PMC:PMC12005450 | DOI:10.1080/27694127.2023.2177932
Protein misfolding and mitochondrial dysfunction in glaucoma
Front Cell Dev Biol. 2025 Apr 25;13:1595121. doi: 10.3389/fcell.2025.1595121. eCollection 2025. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons. Emerging evidence suggests that pathological mechanisms relating to protein folding and […]
TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma
Sci Rep. 2025 May 15;15(1):16852. doi: 10.1038/s41598-025-00638-7. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to injury. Tlr4 is highly expressed in ocular tissues and is known to modulate inflammatory processes in both anterior and posterior segment tissues. […]
The complete mitochondrial genomes of Macrostylophora euteles and Citellophilus tesquorum sungaris and the phylogenetics of known Siphonaptera mitogenomes
Front Vet Sci. 2025 May 1;12:1558328. doi: 10.3389/fvets.2025.1558328. eCollection 2025. ABSTRACT Fleas serve as hosts to a diverse array of pathogens, which present significant medical and veterinary concerns for human and livestock health. The mitochondrial genome (mtDNA) has long been regarded as a classical model in biogenetics and species evolution research. However, the availability of […]
Grx2 maintains GSH/GSSG homeostasis to enhance GPX4-mediated ferroptosis defense in UVB irradiation induced cataract
Exp Eye Res. 2025 May 12:110421. doi: 10.1016/j.exer.2025.110421. Online ahead of print. ABSTRACT PURPOSE: Ultraviolet B (UVB) irradiation induces cataract pathogenesis, and Glutaredoxin 2 (Grx2) deficiency causes the early onset of UVB-induced cataracts. Several researchers have shown that, apart from apoptosis and pyroptosis, UVB irradiation also can induce cell ferroptosis. We explored the role of […]
Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 Pathway
CNS Neurosci Ther. 2025 May;31(5):e70442. doi: 10.1111/cns.70442. ABSTRACT OBJECTIVES: 7,8-Dihydroxyflavone (7,8-DHF) activates the TrkB receptor, offering neuroprotection, yet its pharmacological limitations restrict its safe and effective delivery to the eye and brain, impeding clinical translation. This study explores the protective effects of oral 7,8-DHF on retinal ganglion cells (RGCs) by inhibiting ferroptosis and investigates the […]
Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjogren disease
RMD Open. 2025 May 13;11(2):e005166. doi: 10.1136/rmdopen-2024-005166. ABSTRACT OBJECTIVE: To unveil the clinical implications of mitochondrial RNAs (mt-RNAs) in Sjögren disease (SjD), this study evaluated mt-RNA expression levels in the plasma and saliva of patients with SS and their association with SjD-related features. METHODS: Plasma, saliva and/or peripheral blood mononuclear cells (PBMCs) were collected from […]
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway
Sci Rep. 2025 May 12;15(1):16424. doi: 10.1038/s41598-025-01286-7. ABSTRACT Uveitis is a series of autoimmune eye diseases that can seriously damage people’s eyesight. This study aimed to explore the therapeutic potential of baicalin in treating uveitis, focusing on its modulation of HIF-1α expression and macrophage polarization. Using an experimental autoimmune uveitis (EAU) rat model, we found […]
Restoring AIBP expression in the retina provides neuroprotection in glaucoma
Mol Ther. 2025 May 9:S1525-0016(25)00379-X. doi: 10.1016/j.ymthe.2025.05.009. Online ahead of print. ABSTRACT Glaucoma is a neurodegenerative disease manifested by retinal ganglion cell (RGC) death and irreversible blindness. We have identified apolipoprotein A-I binding protein (AIBP) that controls excessive cholesterol accumulation and neuroinflammation in the retina by upregulating the cholesterol transporter ABCA1 and reducing TLR4 signaling […]