Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjogren disease
RMD Open. 2025 May 13;11(2):e005166. doi: 10.1136/rmdopen-2024-005166. ABSTRACT OBJECTIVE: To unveil the clinical implications of mitochondrial RNAs (mt-RNAs) in Sjögren disease (SjD), this study evaluated mt-RNA expression levels in the plasma and saliva of patients with SS and their association with SjD-related features. METHODS: Plasma, saliva and/or peripheral blood mononuclear cells (PBMCs) were collected from […]
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway
Sci Rep. 2025 May 12;15(1):16424. doi: 10.1038/s41598-025-01286-7. ABSTRACT Uveitis is a series of autoimmune eye diseases that can seriously damage people’s eyesight. This study aimed to explore the therapeutic potential of baicalin in treating uveitis, focusing on its modulation of HIF-1α expression and macrophage polarization. Using an experimental autoimmune uveitis (EAU) rat model, we found […]
Restoring AIBP expression in the retina provides neuroprotection in glaucoma
Mol Ther. 2025 May 9:S1525-0016(25)00379-X. doi: 10.1016/j.ymthe.2025.05.009. Online ahead of print. ABSTRACT Glaucoma is a neurodegenerative disease manifested by retinal ganglion cell (RGC) death and irreversible blindness. We have identified apolipoprotein A-I binding protein (AIBP) that controls excessive cholesterol accumulation and neuroinflammation in the retina by upregulating the cholesterol transporter ABCA1 and reducing TLR4 signaling […]
Microwave-Responsive AlEu-MOFs Potentiate NLRP3-Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave-Immunotherapy
Small. 2025 May 9:e2501157. doi: 10.1002/smll.202501157. Online ahead of print. ABSTRACT Microwave thermotherapy is favored in clinical practice for breast cancer conservation strategies due to its minimally invasive characteristic. Nevertheless, the immunosuppressive tumor microenvironment (TME) significantly attenuates the therapeutic efficacy of anti-tumor immune response, posing challenges in effectively preventing tumor recurrence and metastasis. Pyroptosis, a […]
Recurrent Optic Neuritis as a Misleading Presentation of Leber Hereditary Optic Neuropathy: The Need for High Clinical Suspicion in Young Men
Cureus. 2025 Apr 8;17(4):e81863. doi: 10.7759/cureus.81863. eCollection 2025 Apr. ABSTRACT A 29-year-old Chinese gentleman presented with acute-onset right eye (RE) central scotoma and blurring of vision. Upon presentation, RE visual acuity (VA) was 6/30. The RE optic disc (OD) was mildly swollen, but other findings were unremarkable. A computed tomography (CT) imaging study showed no […]
MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway
Cell Death Discov. 2025 May 8;11(1):226. doi: 10.1038/s41420-025-02439-3. ABSTRACT Diabetic retinopathy (DR) ranks among the primary causes of adult blindness globally. Oxidative stress and mitochondrial dysfunction play a critical role in the progression of DR. Mounting data indicated that small extracellular vesicles (sEVs) of mesenchymal stem cell (MSC) have the ability to transport bioactive chemicals […]
Corrigendum to “In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics” [Mitochondrion 22 (2015) 1-8]
Mitochondrion. 2025 May 7:102044. doi: 10.1016/j.mito.2025.102044. Online ahead of print. NO ABSTRACT PMID:40340170 | DOI:10.1016/j.mito.2025.102044
Fenofibrate inhibits activation of cGAS-STING pathway by alleviating mitochondrial damage to attenuate inflammatory response in diabetic dry eye
Free Radic Biol Med. 2025 May 6:S0891-5849(25)00658-6. doi: 10.1016/j.freeradbiomed.2025.05.383. Online ahead of print. ABSTRACT The cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes (STING) signaling pathway are critical regulators of inflammation. This study aims to investigate the role of the cGAS-STING signaling pathway in diabetic dry eye disease (DDE) and further explore the therapeutic […]
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis
Antioxidants (Basel). 2025 Mar 19;14(3):363. doi: 10.3390/antiox14030363. ABSTRACT The disruption of microglial homeostasis and cytokine release are critical for neuroinflammation post-injury and strongly implicated in retinal neurodegenerative diseases like glaucoma. This study examines microglial responses to chemical hypoxia induced by cobalt chloride (CoCl2) in BV-2 murine microglial cells, focusing on signaling pathways and proteomic alterations. […]
Cyclic cell-penetrating peptide-engineered ceria nanoparticles for non-invasive alleviation of ultraviolet radiation-induced cataract
J Nanobiotechnology. 2025 May 7;23(1):337. doi: 10.1186/s12951-025-03402-1. ABSTRACT Oxidative stress, which results from the accumulation of free radicals, plays a substantial role in cataract formation. Antioxidants have shown promise in mitigating or even preventing this process. However, delivering antioxidants noninvasively to the anterior segment of the eye has been a significant challenge. In this study, […]