Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
Stem Cell Res Ther. 2025 Jul 25;16(1):397. doi: 10.1186/s13287-025-04509-w. ABSTRACT BACKGROUND: Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cells (PRPCs) offers potential for vision restoration. However, substantial early donor cell loss remains a major challenge. This study aims to […]
Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice
Pharmacol Res. 2025 Jul 23:107877. doi: 10.1016/j.phrs.2025.107877. Online ahead of print. ABSTRACT Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with both n-3 DHA […]
Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
Cell Rep Med. 2025 Jul 16:102244. doi: 10.1016/j.xcrm.2025.102244. Online ahead of print. ABSTRACT Mutations in the tripeptidyl peptidase 1 (TPP1) gene lead to neuronal ceroid lipofuscinosis type 2 (CLN2), characterized by lysosomal accumulation of lipofuscins predominantly in the brain and retina. The ocular phenotype is characterized by outer retinal degeneration that leads to vision loss. […]
Acute Bilateral Vision Loss in a Young Male: A Case of Leber’s Hereditary Optic Neuropathy
Cureus. 2025 Jun 23;17(6):e86607. doi: 10.7759/cureus.86607. eCollection 2025 Jun. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is a rare mitochondrial genetic disorder that primarily affects young adult males, leading to acute or subacute painless central vision loss. The condition results from point mutations in mitochondrial DNA, most commonly affecting the ND1, ND4, or ND6 genes, which […]
Developmental Endothelial Locus 1 Reduces Traumatic Brain Injury-Induced Endotheliopathy and Dysregulated Coagulation in Mice
Arterioscler Thromb Vasc Biol. 2025 Jul 24. doi: 10.1161/ATVBAHA.125.322515. Online ahead of print. ABSTRACT BACKGROUND: Traumatic brain injury (TBI) induces endothelial injury (endotheliopathy) that disrupts the vascular barrier to cause cerebral hemorrhage and inflammation and allows the release of extracellular vesicles (EVs) from injured brain cells into the circulation. These EVs are highly procoagulant, causing […]
Berberine Inhibits High Glucose-Induced Ferroptosis in Retinal Vascular Endothelial Cells: Mechanism and Implications
Exp Eye Res. 2025 Jul 21:110531. doi: 10.1016/j.exer.2025.110531. Online ahead of print. ABSTRACT This study investigates ferroptosis in human retinal microvascular endothelial cells (HRMECs) under high-glucose conditions and explores the therapeutic potential of Berberine (BBR) in mitigating this process. Using Western blotting and RT-qPCR, we observed that prolonged high glucose (48h) significantly downregulated GPX4 and […]
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy
Int Immunopharmacol. 2025 Jul 22;163:115240. doi: 10.1016/j.intimp.2025.115240. Online ahead of print. ABSTRACT To identify platelet-related biomarkers in diabetic retinopathy (DR) and clarify the role of lymphocyte cytosolic protein 2 (LCP2) and the PD-1/PD-L1 pathway in DR pathogenesis, we employed STZ-induced diabetic rats and a high-glucose (HG) T cell-RPE cell co-culture model. Platelet-related genes were screened […]
IL-1β-Mediated Immunometabolic Adaptation in Corneal Epithelial Cells
J Inflamm Res. 2025 Jul 18;18:9537-9555. doi: 10.2147/JIR.S495323. eCollection 2025. ABSTRACT PURPOSE: As an external mucosal surface, the corneal epithelium is subject to a barrage of stressors that are known to trigger inflammation. IL-1β, a master regulator of inflammation, is secreted into the preocular tear film by ocular surface epithelial cells and infiltrating immune cells. […]
CD38-NAD(+) Axis: New Insights into Glaucoma Therapy
Mol Neurobiol. 2025 Jul 22. doi: 10.1007/s12035-025-05243-3. Online ahead of print. ABSTRACT Glaucoma is a globally recognized leading cause of irreversible blindness, and its progression is closely associated with retinal ganglion cell (RGC) degeneration and mitochondrial dysfunction. Recently, there has been growing interest in the role of nicotinamide adenine dinucleotide (NAD +) and its regulatory […]
TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function
Clin Ophthalmol. 2025 Jul 16;19:2343-2362. doi: 10.2147/OPTH.S521660. eCollection 2025. ABSTRACT BACKGROUND: Recent studies have demonstrated that mitochondrial dysfunction is pivotal in early diabetic retinopathy (DR). Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis. METHODS: We established in vivo and in vitro models of DR. Hematoxylin and […]