Melatonin in Glaucoma: Integrative Mechanisms of Intraocular Pressure Control and Neuroprotection
Biomedicines. 2025 May 16;13(5):1213. doi: 10.3390/biomedicines13051213. ABSTRACT Background: Glaucoma is a leading cause of irreversible visual loss worldwide, characterized by progressive retinal ganglion cell (RGC) degeneration and optic nerve damage. Current therapies mainly focus on lowering intraocular pressure (IOP), yet fail to address pressure-independent neurodegenerative mechanisms. Melatonin, an endogenously produced indoleamine, has gained attention for […]
Exotropia in a Patient With a Novel Homozygous 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein (HPDL) Variant
Cureus. 2025 Apr 27;17(4):e83070. doi: 10.7759/cureus.83070. eCollection 2025 Apr. ABSTRACT The 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) is a mitochondria-localized protein involved in the biosynthesis of coenzyme Q10 in the electron transfer system, and its variants have been reported to cause progressive neurodegenerative diseases such as neonatal leukoencephalopathy and hereditary spastic paraplegia. In this case report, we […]
Exploring the Phenotypic Heterogeneity and Bioenergetic Profile of the m.13513G>A mtDNA Substitution: A Heteroplasmy Perspective
Int J Mol Sci. 2025 May 10;26(10):4565. doi: 10.3390/ijms26104565. ABSTRACT The m.13513G>A (p.Asp393Asn) substitution in the MT-ND5 (Mitochondrially Encoded NADH/Ubiquinone Oxidoreductase Core Subunit 5) gene is a common pathogenic variant associated with primary mitochondrial disorders. It frequently causes Leigh syndrome and mitochondrial encephalomyopathy with lactate acidosis and stroke-like episodes (MELAS). In this study, we present […]
Efficacy and Safety of Visible and Near-Infrared Photobiomodulation Therapy on Astenospermic Human Sperm: Wavelength-Dependent Regulation of Nitric Oxide Levels and Mitochondrial Energetics
Biology (Basel). 2025 May 1;14(5):491. doi: 10.3390/biology14050491. ABSTRACT Male infertility is a growing global concern, with asthenozoospermia being an important contributing factor. Mitochondrial dysfunction and changes in the metabolism of nitric oxide (NO) are key determinants of reduced sperm motility. This study investigates the effects of photobiomodulation (PBM) with visible and near-infrared (NIR) laser light […]
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice
Aging Dis. 2025 May 15. doi: 10.14336/AD.2025.0188. Online ahead of print. ABSTRACT Parabacteroides distasonis (Pd), a core member of the human gut microbiota, is enriched in centenarians, suggesting a potential role in promoting organismal resilience. While Pd supplementation has been shown to alleviate cancer and inflammatory diseases, its ability to mitigate the decline associated with […]
The crossroads of Leber hereditary optic neuropathy and autosomal dominant optic Atrophy: Clinical profiles of patients with coexisting pathogenic genetic variants
Am J Ophthalmol Case Rep. 2025 Apr 29;38:102346. doi: 10.1016/j.ajoc.2025.102346. eCollection 2025 Jun. ABSTRACT PURPOSE: Leber Hereditary Optic Neuropathy (LHON) and Autosomal Dominant Optic Atrophy (ADOA) are hereditary optic neuropathies characterized by mitochondrial dysfunctions causing destruction to the retinal ganglion cells and their axons, painless bilateral vision loss and symmetrical temporal pallor of the optic […]
Unveiling the HSP90 inhibitor mediated effects on endoplasmic reticulum stress and redox signaling:from a cancer inhibitor to retinal degeneration catalyst
Free Radic Biol Med. 2025 May 23:S0891-5849(25)00697-5. doi: 10.1016/j.freeradbiomed.2025.05.414. Online ahead of print. ABSTRACT Retinal degeneration (RD) is a class of polygenic blind eye disease characterized by photoreceptors loss and dysfunction of retinal pigment epithelium. Thus far, there is no effective treatment to save the declining vision in RD patients. Animal models are highly precious […]
Targeting Mitochondrial Dysfunction: Innovative Strategies to Combat Glaucoma Neuroinflammation
Exp Eye Res. 2025 May 21:110441. doi: 10.1016/j.exer.2025.110441. Online ahead of print. ABSTRACT Glaucomatous optic neuropathy represents a prevalent optic nerve degenerative disease. Neuroinflammation is recognized as a significant mechanism underlying optic nerve damage in glaucoma; however, the precise mechanisms driving neuroinflammation remain largely elusive. Existing studies have indicated that microglia-driven neuroinflammation is pivotal for […]
Integration of Animal, Population, and Toxicogenomic Evidence on the Hematotoxic and Immunosuppressive Effects of Environmental Exposure to PFAS Mixtures in Adolescents
Environ Sci Technol. 2025 May 23. doi: 10.1021/acs.est.5c01138. Online ahead of print. ABSTRACT Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are emerging contaminants widely found in drinking water and food, potentially entering the human body through these sources. To investigate these effects, we simulated PFAS exposure doses in animal models, ranging from general population to occupational levels, […]
Genetic mechanisms of hemispheric functional connectivity in diabetic retinopathy: a joint neuroimaging and transcriptomic study
Front Cell Dev Biol. 2025 May 6;13:1590627. doi: 10.3389/fcell.2025.1590627. eCollection 2025. ABSTRACT BACKGROUND: DR represents a major cause of global vision loss; however, the genetic basis of functional homotopy,a critical neurobiological metric reflecting interhemispheric functional synchronization, remains largely unexplored. Emerging evidence suggests that DR patients exhibiting aberrant VMHC may potentially associate with distinct transcriptional profiles. […]