Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration
Commun Biol. 2025 Jul 29;8(1):1118. doi: 10.1038/s42003-025-08565-z. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of central vision impairment among the elderly. Geographic atrophy is a defining characteristic of AMD, but the detailed mechanism for massive loss of retinal pigment epithelium (RPE) cells is not fully understood. In this study, we found that Z-DNA […]
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis
Drug Des Devel Ther. 2025 Jul 22;19:6219-6233. doi: 10.2147/DDDT.S523455. eCollection 2025. ABSTRACT INTRODUCTION: Alectinib is a widely used first-line ALK inhibitor for fusion-positive non-small cell lung cancer. However, its clinical use is limited by hepatotoxicity, and its mechanism remains unclear. This study aims to elucidate how alectinib induces liver injury and to explore a potential […]
Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration
ACS Omega. 2025 Jul 7;10(28):30467-30488. doi: 10.1021/acsomega.5c02227. eCollection 2025 Jul 22. ABSTRACT Age-related macular degeneration (AMD) is a progressive, late-onset, genetic (CFH, HTRA), and environmental (smoking, aging) ocular disease that is a leading cause of blindness affecting more than 200 million people worldwide. New treatments are required for fibrosis, autophagy, and microglia-driven pathologies in AMD […]
Roles of 670 nm Photobiomodulation on Rat Anterior Ischemic Optic Neuropathy: Enhancing RGC Survival, Mitochondrial Function, and Anti-Inflammatory Response
Antioxidants (Basel). 2025 Jul 18;14(7):886. doi: 10.3390/antiox14070886. ABSTRACT Non-arteritic anterior ischemic optic neuropathy (NAION) leads to retinal ganglion cell (RGC) loss and visual impairment, with no effective treatment. This study investigated the neuroprotective effect of 670 nm photobiomodulation (PBM) in a rat NAION model (rNAION). Wistar rats received 670 nm light exposure (10-min, 3000 lux) […]
Effect of Hypoxia on Adult Müller Glia Cultures
Biomedicines. 2025 Jul 16;13(7):1743. doi: 10.3390/biomedicines13071743. ABSTRACT Background: The retina, a light-sensitive tissue of the central nervous system that is located at the posterior part of the eye, is particularly vulnerable to alterations in oxygen levels. In various retinal diseases, such as central retinal vein occlusion, glaucoma, and diabetic retinopathy, hypoxia (a condition of low […]
SIRT1 Alleviates Hyperglycemia-induced Oxidative Stress and Dysfunction of Limbal Niche Cells by Deacetylating FOXO1
Free Radic Biol Med. 2025 Jul 24:S0891-5849(25)00847-0. doi: 10.1016/j.freeradbiomed.2025.07.032. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is a major cause of vision loss, with a complex pathogenesis. In particular, the mechanisms by which hyperglycemia affects the limbal remain unclear. The purpose of this study was to investigate the impact of hyperglycemia on oxidative stress […]
Rhodiola tangutica (Maxim.) S. H. Fu protects blood-retinal barrier in hypoxia-induced retinal injury rats by down-regulating HIF-1α/eNOS/NO pathway
J Ethnopharmacol. 2025 Jul 24:120325. doi: 10.1016/j.jep.2025.120325. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Rhodiola tangutica (Maxim.) S. H. Fu (TS) (RT), as a traditional Tibetan medicine, has been used for treating acute and chronic mountain sickness in Qinghai Province of China for a long time. High altitude retinopathy (HAR), exposed to acute hypobaric hypoxia, […]
Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development
Cells. 2025 Jul 17;14(14):1097. doi: 10.3390/cells14141097. ABSTRACT Intrauterine growth restriction (IUGR) is a critical challenge in perinatal medicine and is associated with significant morbidity and mortality. This review explores the intricate involvement of early developmental senescence in IUGR. We highlight the dual role of cellular senescence in both normal development and pathological conditions, emphasizing the […]
Fundus Autofluorescence in Inherited Retinal Disease: A Review
Cells. 2025 Jul 16;14(14):1092. doi: 10.3390/cells14141092. ABSTRACT Fundus autofluorescence (FAF) is a non-invasive retinal imaging technique that helps visualize naturally occurring fluorophores, such as lipofuscin, and provides valuable insight into retinal diseases-particularly inherited retinal diseases (IRDs). FAF is especially useful in detecting subclinical or early-stage IRDs and in monitoring disease progression over time. In Stargardt […]
Recent Advances in Targeted Immunomodulatory Therapies for Chronic Ocular Surface Diseases
Semin Ophthalmol. 2025 Jul 25:1-13. doi: 10.1080/08820538.2025.2536766. Online ahead of print. ABSTRACT PURPOSE: To review and compare the mechanisms of action, clinical efficacy, and safety profiles of topical immunosuppressive and immunomodulatory agents for the management of chronic ocular surface diseases. METHODS: A comprehensive review of the literature was conducted using PubMed, Scopus, and Web of […]