The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins
Front Cell Neurosci. 2025 Aug 22;19:1634262. doi: 10.3389/fncel.2025.1634262. eCollection 2025. ABSTRACT BACKGROUND: Imeglimin (Ime), the first in a novel class of antidiabetic agents, has potential therapeutic effects on diabetic peripheral neuropathy (DPN). This study aimed to evaluate and compare the effects on cellular metabolic function and reactive oxygen species (ROS) levels in high glucose-treated mouse […]
Light-emitting diode-derived blue light overexposure accelerates corneal endothelial cell aging by inducing abnormal ROS accumulation
J Photochem Photobiol B. 2025 Sep 1;272:113252. doi: 10.1016/j.jphotobiol.2025.113252. Online ahead of print. ABSTRACT Blue light, defined as short-wavelength visible light ranging from 400 to 500 nm, is recognized for its high energy within the visible light spectrum. The prevalent use of light-emitting diodes (LEDs) has significantly increased exposure to blue light. Corneal endothelial cells […]
A novel protein encoded by hsa_circ_0068626 contributes to age-related cataract via the p62/Keap1/Nrf2 signaling pathway-mediated ferroptosis
Exp Eye Res. 2025 Sep 3:110601. doi: 10.1016/j.exer.2025.110601. Online ahead of print. ABSTRACT This study investigates whether circular RNAs (circRNAs) modulate ferroptosis in lens epithelial cells (LECs) during age-related cataract (ARC) pathogenesis via novel encoded proteins. Initial circRNA-sequencing identified hsa_circ_0068626 (circTFRC) as significantly upregulated in ARC, predominantly localized to the cytoplasm through nuclear-cytoplasmic fractionation and […]
Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation
Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2502483122. doi: 10.1073/pnas.2502483122. Epub 2025 Sep 5. ABSTRACT Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows […]
Dimethyl fumarate is an inhibitor of pathological angiogenesis
Cell Signal. 2025 Sep 2:112106. doi: 10.1016/j.cellsig.2025.112106. Online ahead of print. ABSTRACT Vascular endothelial growth factor (VEGF), a pro-angiogenic molecule, supports blood vessel growth during wound healing but also drives pathological neovascularization in blinding eye diseases such as neovascular age-related macular degeneration (nAMD). Dimethyl fumarate (DMFu), an FDA-approved drug for multiple sclerosis, has previously shown […]
Metformin may alter the course of Leber’s hereditary optic neuropathy: a case report
Front Med (Lausanne). 2025 Aug 19;12:1609941. doi: 10.3389/fmed.2025.1609941. eCollection 2025. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a rare inherited mitochondrial disease caused by variants in mitochondrial DNA (mtDNA) transmitted exclusively through the maternal line. The disease predominantly affects young males and is characterized by progressive bilateral vision loss. Idebenone, a well-studied drug, modestly enhances […]
Oxidative stress-related biomarkers in thyroid eye disease: evidence from bioinformatics analysis and experimental validation
Front Immunol. 2025 Aug 18;16:1635712. doi: 10.3389/fimmu.2025.1635712. eCollection 2025. ABSTRACT BACKGROUND: Oxidative stress is a key contributor to the pathogenesis of the autoimmune condition thyroid eye disease (TED). However, its precise molecular mechanisms and reliable biomarkers remain unclear. Bioinformatics enables the identification of differentially expressed genes through transcriptomic analysis. However, distinguishing truly relevant findings from […]
The Therapeutic Potential of Flavonols in Alzheimer’s Disease: Inhibiting Amyloid-β, Oxidative Stress, and Neuroinflammation
Biofactors. 2025 Sep-Oct;51(5):e70047. doi: 10.1002/biof.70047. ABSTRACT Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) aggregation, oxidative stress, and neuroinflammation, remains a significant global health challenge. This study investigates the therapeutic potential of flavonols-quercetin, kaempferol, myricetin, and fisetin-in targeting Aβ aggregation and mitigating AD pathology through diverse molecular mechanisms. Our findings reveal that […]
High expression of Mrps10 in diabetic retinopathy: A bioinformatics analysis based on public transcriptomic data
Medicine (Baltimore). 2025 Aug 29;104(35):e44179. doi: 10.1097/MD.0000000000044179. ABSTRACT Diabetic retinopathy (DR) is one of the most common microvascular complications in diabetic patients, severely affecting their vision and quality of life. However, the precise molecular mechanisms underlying DR remain unclear. In recent years, mitochondrial ribosomal protein S10 (Mrps10) gene has gained attention due to its high […]
Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link?
Front Neurol. 2025 Aug 13;16:1616992. doi: 10.3389/fneur.2025.1616992. eCollection 2025. ABSTRACT INTRODUCTION: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited condition due to mitochondrial DNA (mtDNA) mutations usually affecting young men within their thirties, while women seem protected by estrogens with a female-to-male ratio of 1:3. Late-onset cases (over 40 years of age) are usually […]