miR142 silencing alleviates retinal inflammation by impairing mitochondrial function and reprogramming metabolism of CD4(+) T cells via targeting MTFR1
Int Immunopharmacol. 2025 May 6;157:114727. doi: 10.1016/j.intimp.2025.114727. Online ahead of print. ABSTRACT BACKGROUND: Autoimmune uveitis is a sight-threatening inflammatory disease of the retina. MicroRNA-142 (miR-142) has been implicated in its pathogenesis. This study aimed to elucidate the role of miR-142 in uveitis and its underlying mechanisms. METHODS: The expression of miR-142-3p was analyzed in peripheral […]
cGAS-STING-NFκB pathway plays a role in burn injury-induced muscle wasting
Shock. 2025 Apr 28. doi: 10.1097/SHK.0000000000002613. Online ahead of print. ABSTRACT BACKGROUND: Muscle wasting (MW) is a ubiquitous and debilitating consequence of major burn injury (BI), leading to both short- and long-term health complications. The cGAS-STING-NFκB pathway is a key mediator of inflammatory responses triggered by infection, cellular stress, and tissue damage. This study investigated […]
Isolated and Syndromic Genetic Optic Neuropathies: A Review of Genetic and Phenotypic Heterogeneity
Int J Mol Sci. 2025 Apr 20;26(8):3892. doi: 10.3390/ijms26083892. ABSTRACT Nonsyndromic and syndromic hereditary optic neuropathies (HONs) encompass a variety of genetic illnesses that cause progressive optic nerve damage, resulting in considerable vision impairment. These disorders result from pathogenic variants in mitochondrial or nuclear DNA, impacting essential cellular processes like oxidative phosphorylation, mitochondrial dynamics, and […]
Innovative technologies for the treatment of dry age-related macular degeneration (AMD) – modern therapeutic perspectives and their future
Rom J Ophthalmol. 2025 Jan-Mar;69(1):10-16. doi: 10.22336/rjo.2025.03. ABSTRACT PURPOSE: This review explores modern therapeutic options for the dry form of age-related macular degeneration (AMD), a condition representing one of the most significant challenges in ophthalmology due to its progressive nature and lack of effective treatment. The study discusses innovative approaches, evaluates available methods, and examines […]
Isoquercetin Alleviates Diabetic Retinopathy Via Inhibiting p53-Mediated Ferroptosis
Cell Biol Int. 2025 May 7. doi: 10.1002/cbin.70027. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a retinal vasculopathy stemming from diabetes mellitus, characterized by microvascular changes in the retina that can lead to visual impairment or even blindness. Ferroptosis, a form of regulated cell death driven by iron accumulation and lipid peroxidation, has […]
DNA methyltransferase 1 modulates mitochondrial function through bridging m(5)C RNA methylation
Mol Cell. 2025 Apr 30:S1097-2765(25)00361-2. doi: 10.1016/j.molcel.2025.04.019. Online ahead of print. ABSTRACT DNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) disorder. Here, we demonstrated that DNMT1 has the […]
A Spontaneous Nonhuman Primate Model of Inherited Retinal Degeneration
JCI Insight. 2025 May 6:e190807. doi: 10.1172/jci.insight.190807. Online ahead of print. ABSTRACT Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases in particular are significant in their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform macular dystrophy (BVMD), caused by variants […]
Poldip2 aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway
Life Sci. 2025 May 2:123681. doi: 10.1016/j.lfs.2025.123681. Online ahead of print. ABSTRACT BACKGROUND AND AIM: Inflammation is a crucial aspect of the pathophysiology of diabetic retinopathy (DR). Polymerase delta-interacting protein 2 (Poldip2) has been linked to inflammation in various disorders, but its role in DR remains unclear. This study aims to elucidate the underlying mechanisms […]
Metal-phenolic epigallocatechin gallate‑zinc antioxidant nanoparticles for cataract treatment
J Control Release. 2025 May 2:113798. doi: 10.1016/j.jconrel.2025.113798. Online ahead of print. ABSTRACT In cataract, oxidative stress plays an important role. It breaks the balance of the antioxidant defense system by destroying biological macromolecules such as proteins, lipids and nucleic acids in the lens, induces lens opacity, and then leads to the formation of cataract. […]
Valine acts as an early biomarker and exacerbates pathological cardiac hypertrophy by impairing mitochondrial quality control
Atherosclerosis. 2025 Apr 26;405:119216. doi: 10.1016/j.atherosclerosis.2025.119216. Online ahead of print. ABSTRACT OBJECTIVE: Pathological cardiac hypertrophy is an independent risk factor for heart failure (HF). Early identification and timely treatment are crucial for significantly delaying the progression of HF. METHODS: Targeted amino acid metabolomics and RNA sequencing (RNA-seq) were combined to explore the underlying mechanism. In […]