Technological advances in the diagnosis and management of inherited optic neuropathies
Front Neurol. 2025 Jul 25;16:1609033. doi: 10.3389/fneur.2025.1609033. eCollection 2025. ABSTRACT Preferential degeneration of retinal ganglion cells (RGCs) is a defining feature of the inherited optic neuropathies (IONs), a group of monogenic eye diseases predominately comprising Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA). Their pathogenesis is characterised by mitochondrial dysfunction, which causes […]
hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis
J Mol Histol. 2025 Aug 9;56(4):264. doi: 10.1007/s10735-025-10535-y. ABSTRACT OBJECTIVE: Diabetic retinopathy (DR) is a leading cause of vision loss, driven by hyperglycemia-induced human retinal microvascular endothelial cell (HRMEC) dysfunction, mitochondrial impairment, oxidative stress, inflammation, and aberrant angiogenesis. Circular RNAs (circRNAs) have emerged as critical regulators in various ocular pathologies, yet their contributions to DR […]
Unlocking the potential of GLP-1 receptor agonists in ocular therapeutics: from molecular pathways to clinical impact
Front Pharmacol. 2025 Jul 24;16:1618079. doi: 10.3389/fphar.2025.1618079. eCollection 2025. ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for diabetes and obesity, exhibit pleiotropic effects-including anti-inflammatory, antioxidant, and neuroprotective properties-that position them as transformative candidates for ocular therapeutics. Ocular diseases such as glaucoma and diabetic retinopathy (DR) are driven by multifactorial pathogenesis. Current therapies often target […]
‘Adrift From the World’: Exploring the Lived Experiences of Individuals Affected by an Inherited Optic Neuropathy in the United Kingdom – A Qualitative Study
Value Health. 2025 Aug 5:S1098-3015(25)02490-8. doi: 10.1016/j.jval.2025.07.023. Online ahead of print. ABSTRACT OBJECTIVES: Little is understood about the lived experiences of individuals affected by inherited optic neuropathies (IONs) in the United Kingdom. The aim of this study was to understand how autosomal dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON), the two more […]
Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis
Transl Vis Sci Technol. 2025 Aug 1;14(8):13. doi: 10.1167/tvst.14.8.13. ABSTRACT PURPOSE: This study aims to understand the differences in cellular and molecular patterns between the Main and Accessory (Acc) regions of pterygium tissue, with a focus on inflammation and mitochondrial energy metabolism. METHODS: We collected bulk RNA sequencing (RNA-seq) data from six pterygium patients and […]
Metformin in Diabetic Retinopathy: Mechanisms, Therapeutic Potential, and Barriers
Cureus. 2025 Jul 7;17(7):e87455. doi: 10.7759/cureus.87455. eCollection 2025 Jul. ABSTRACT The primary aim of diabetic retinopathy (DR) management is to prevent or slow the decline of vision loss. While current treatments for DR are effective in the advanced stages, they may not be as effective in the early phases of the disease. Metformin is among […]
Natural History and Biomarker Challenges in Dominant Optic Atrophy: Implications for Therapeutic Studies
Clin Exp Ophthalmol. 2025 Aug;53(6):597-599. doi: 10.1111/ceo.14583. NO ABSTRACT PMID:40765395 | DOI:10.1111/ceo.14583
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells
Structure. 2025 Jul 25:S0969-2126(25)00258-8. doi: 10.1016/j.str.2025.07.010. Online ahead of print. ABSTRACT Combining three-dimensional (3D) visualization with elemental analysis of vitrified cells can provide crucial insights into subcellular structures and elemental compositions in their native environments. We present a coordinated approach using cryogenic electron energy loss spectroscopy (cryoEELS) and cryogenic electron tomography (cryoET) to characterize the […]
Construction and characteristics of an adjustable biomechanical in vitro corneal stromal model simulating keratoconus pathological features
Mater Today Bio. 2025 Jul 23;34:102130. doi: 10.1016/j.mtbio.2025.102130. eCollection 2025 Oct. ABSTRACT Keratoconus (KC) is a prevalent ectatic corneal disease influenced by corneal biomechanics, though its pathogenesis remains unclear. Constructing an in vitro corneal model with adjustable biomechanics is essential for studying keratoconus. In this study, a KC disease group (L group) was created using […]
MiRNA-122-5p Promotes Retinal Ganglion Cell Oxidative Damage by Targeting DJ-1 in Hyperglycemic Retina
Free Radic Biol Med. 2025 Aug 2:S0891-5849(25)00869-X. doi: 10.1016/j.freeradbiomed.2025.07.054. Online ahead of print. ABSTRACT Mitochondrial dysfunction, induced by prolonged hyperglycemia, is widely regarded as a central factor in oxidative stress and retinal ganglion cell (RGC) degeneration in diabetic retinopathy (DR). DJ-1 (PARK7) acts as a crucial antioxidant defense mechanism, stabilizing mitochondrial structure and redox balance. […]