MiRNA-122-5p Promotes Retinal Ganglion Cell Oxidative Damage by Targeting DJ-1 in Hyperglycemic Retina
Free Radic Biol Med. 2025 Aug 2:S0891-5849(25)00869-X. doi: 10.1016/j.freeradbiomed.2025.07.054. Online ahead of print. ABSTRACT Mitochondrial dysfunction, induced by prolonged hyperglycemia, is widely regarded as a central factor in oxidative stress and retinal ganglion cell (RGC) degeneration in diabetic retinopathy (DR). DJ-1 (PARK7) acts as a crucial antioxidant defense mechanism, stabilizing mitochondrial structure and redox balance. […]
Adipose-derived mesenchymal stem cells and retinal pigment epithelial cells interactions in a stress environment via tunneling nanotubes
PLoS One. 2025 Aug 4;20(8):e0329672. doi: 10.1371/journal.pone.0329672. eCollection 2025. ABSTRACT This study aims to demonstrate the formation of tunneling tubes (TNTs) between adipose-derived mesenchymal stem cells (AdMSCs) and retinal pigment epithelial cells (RPE-1) and their alterations in response to experimental stress conditions. Serum starvation was employed as a stress condition to induce TNTs between the […]
Digitalization of surgical features improves surgical accuracy via surgeon guidance and robotization
NPJ Digit Med. 2025 Aug 2;8(1):497. doi: 10.1038/s41746-025-01887-6. ABSTRACT The evolution of surgical techniques aims to augment surgeons’ capabilities through digital guidance and robotization for higher precision and consistency. Currently, surgeries heavily rely on surgeon’s experience and visual judgment, causing operation variations. Artificial intelligence (AI) offers a solution by extracting and digitizing surgical trajectories and […]
IVF add-ons: effectiveness, efficiency, safety, and additional costs – A position statement by the SIFES-MR
Eur J Obstet Gynecol Reprod Biol. 2025 Jul 29;313:114609. doi: 10.1016/j.ejogrb.2025.114609. Online ahead of print. ABSTRACT OBJECTIVE: To critically appraise IVF add-ons, based on current evidence, international recommendations, and expert consensus from SIFES-MR. STUDY DESIGN: Consensus developed by a multidisciplinary panel of Italian reproductive medicine experts over two years, based on clinical expertise, revision of […]
Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism
J Adv Res. 2025 Jul 28:S2090-1232(25)00573-9. doi: 10.1016/j.jare.2025.07.044. Online ahead of print. ABSTRACT INTRODUCTION: Fungal infections represent a global health concern with significant implications for human well-being. Among them, refractory and sight-threatening fungal keratitis (FK) poses a serious threat to ocular health. This underscores an urgent need for developing novel antifungal agents to meet clinical […]
Mitochondrial Disorder: Kearns-Sayre Syndrome
Adv Exp Med Biol. 2025;1467:173-175. doi: 10.1007/978-3-031-72230-1_30. ABSTRACT Mitochondrial DNA (mtDNA) deletions can be identified, and rarely point mutation. PMID:40736832 | DOI:10.1007/978-3-031-72230-1_30
Drug-Induced Retinal Toxicity
Adv Exp Med Biol. 2025;1467:253-262. doi: 10.1007/978-3-031-72230-1_50. ABSTRACT Despite the protective blood-ocular barrier, various drugs can induce retinal damage, manifesting as retinal pigment epithelium dysfunction, photoreceptor degeneration, vascular abnormalities, ganglion cell damage, optic nerve impairment, or uveitis. These toxic effects are often linked to mechanisms such as oxidative stress, mitochondrial dysfunction, and cytoskeletal disruption. Early […]
Mitochondrial Disorder: Maternally Inherited Diabetes and Deafness
Adv Exp Med Biol. 2025;1467:177-180. doi: 10.1007/978-3-031-72230-1_31. ABSTRACT Patients with maternally inherited diabetes and deafness (MIDD) have insulin-dependent diabetes with relatively low BMI; usually the onset of the diabetes is during the third or fourth decade of life and it is associated with progressive neurosensory deafness. PMID:40736833 | DOI:10.1007/978-3-031-72230-1_31
Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration
Commun Biol. 2025 Jul 29;8(1):1118. doi: 10.1038/s42003-025-08565-z. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of central vision impairment among the elderly. Geographic atrophy is a defining characteristic of AMD, but the detailed mechanism for massive loss of retinal pigment epithelium (RPE) cells is not fully understood. In this study, we found that Z-DNA […]
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis
Drug Des Devel Ther. 2025 Jul 22;19:6219-6233. doi: 10.2147/DDDT.S523455. eCollection 2025. ABSTRACT INTRODUCTION: Alectinib is a widely used first-line ALK inhibitor for fusion-positive non-small cell lung cancer. However, its clinical use is limited by hepatotoxicity, and its mechanism remains unclear. This study aims to elucidate how alectinib induces liver injury and to explore a potential […]