Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration
ACS Omega. 2025 Jul 7;10(28):30467-30488. doi: 10.1021/acsomega.5c02227. eCollection 2025 Jul 22. ABSTRACT Age-related macular degeneration (AMD) is a progressive, late-onset, genetic (CFH, HTRA), and environmental (smoking, aging) ocular disease that is a leading cause of blindness affecting more than 200 million people worldwide. New treatments are required for fibrosis, autophagy, and microglia-driven pathologies in AMD […]
Roles of 670 nm Photobiomodulation on Rat Anterior Ischemic Optic Neuropathy: Enhancing RGC Survival, Mitochondrial Function, and Anti-Inflammatory Response
Antioxidants (Basel). 2025 Jul 18;14(7):886. doi: 10.3390/antiox14070886. ABSTRACT Non-arteritic anterior ischemic optic neuropathy (NAION) leads to retinal ganglion cell (RGC) loss and visual impairment, with no effective treatment. This study investigated the neuroprotective effect of 670 nm photobiomodulation (PBM) in a rat NAION model (rNAION). Wistar rats received 670 nm light exposure (10-min, 3000 lux) […]
Effect of Hypoxia on Adult Müller Glia Cultures
Biomedicines. 2025 Jul 16;13(7):1743. doi: 10.3390/biomedicines13071743. ABSTRACT Background: The retina, a light-sensitive tissue of the central nervous system that is located at the posterior part of the eye, is particularly vulnerable to alterations in oxygen levels. In various retinal diseases, such as central retinal vein occlusion, glaucoma, and diabetic retinopathy, hypoxia (a condition of low […]
SIRT1 Alleviates Hyperglycemia-induced Oxidative Stress and Dysfunction of Limbal Niche Cells by Deacetylating FOXO1
Free Radic Biol Med. 2025 Jul 24:S0891-5849(25)00847-0. doi: 10.1016/j.freeradbiomed.2025.07.032. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is a major cause of vision loss, with a complex pathogenesis. In particular, the mechanisms by which hyperglycemia affects the limbal remain unclear. The purpose of this study was to investigate the impact of hyperglycemia on oxidative stress […]
Rhodiola tangutica (Maxim.) S. H. Fu protects blood-retinal barrier in hypoxia-induced retinal injury rats by down-regulating HIF-1α/eNOS/NO pathway
J Ethnopharmacol. 2025 Jul 24:120325. doi: 10.1016/j.jep.2025.120325. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Rhodiola tangutica (Maxim.) S. H. Fu (TS) (RT), as a traditional Tibetan medicine, has been used for treating acute and chronic mountain sickness in Qinghai Province of China for a long time. High altitude retinopathy (HAR), exposed to acute hypobaric hypoxia, […]
Fundus Autofluorescence in Inherited Retinal Disease: A Review
Cells. 2025 Jul 16;14(14):1092. doi: 10.3390/cells14141092. ABSTRACT Fundus autofluorescence (FAF) is a non-invasive retinal imaging technique that helps visualize naturally occurring fluorophores, such as lipofuscin, and provides valuable insight into retinal diseases-particularly inherited retinal diseases (IRDs). FAF is especially useful in detecting subclinical or early-stage IRDs and in monitoring disease progression over time. In Stargardt […]
Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development
Cells. 2025 Jul 17;14(14):1097. doi: 10.3390/cells14141097. ABSTRACT Intrauterine growth restriction (IUGR) is a critical challenge in perinatal medicine and is associated with significant morbidity and mortality. This review explores the intricate involvement of early developmental senescence in IUGR. We highlight the dual role of cellular senescence in both normal development and pathological conditions, emphasizing the […]
Recent Advances in Targeted Immunomodulatory Therapies for Chronic Ocular Surface Diseases
Semin Ophthalmol. 2025 Jul 25:1-13. doi: 10.1080/08820538.2025.2536766. Online ahead of print. ABSTRACT PURPOSE: To review and compare the mechanisms of action, clinical efficacy, and safety profiles of topical immunosuppressive and immunomodulatory agents for the management of chronic ocular surface diseases. METHODS: A comprehensive review of the literature was conducted using PubMed, Scopus, and Web of […]
Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
Stem Cell Res Ther. 2025 Jul 25;16(1):397. doi: 10.1186/s13287-025-04509-w. ABSTRACT BACKGROUND: Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cells (PRPCs) offers potential for vision restoration. However, substantial early donor cell loss remains a major challenge. This study aims to […]
Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice
Pharmacol Res. 2025 Jul 23:107877. doi: 10.1016/j.phrs.2025.107877. Online ahead of print. ABSTRACT Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with both n-3 DHA […]