Piperine and its nanoformulations: A mechanistic review of their anti-cancer activities
Biomed Pharmacother. 2025 Apr 23;187:118075. doi: 10.1016/j.biopha.2025.118075. Online ahead of print. ABSTRACT Piperine, an active compound found in black pepper, exhibits promising anti-cancer properties by targeting critical signaling pathways involved in cancer cell proliferation, migration, and invasion. This review explores the diverse mechanisms through which piperine exerts its effects, including inhibition of the PI3K/Akt/mTOR and […]
OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation
J Transl Med. 2025 Apr 24;23(1):471. doi: 10.1186/s12967-025-06471-w. ABSTRACT BACKGROUND: Autosomal dominant optic atrophy (ADOA), a leading common inherited optic neuropathy, arises from progressive retinal ganglion cell degeneration, often linked to OPA1 mutations. OPA1, a mitochondrial GTPase, regulates mitochondrial fusion, crista structure, and apoptosis. While GTPase-related dysfunction is well-studied, the role of other OPA1 domains […]
Advances in origin, evolution, and pathogenesis of optic disc drusen: A narrative review
Indian J Ophthalmol. 2025 May 1;73(5):637-647. doi: 10.4103/IJO.IJO_937_24. Epub 2025 Apr 24. ABSTRACT Optic disc drusen (ODD) is acellular calcified deposits found mainly in front of the lamina cribrosa within the optic nerve. It can cause chronic or acute vision loss. There has been progress in clinical diagnosis using ophthalmic multimodal imaging in recent years. […]
Role of IP3R2-Mediated mitochondrial calcium homeostasis in early hypoxic stress injury of retinal pigment epithelial cells
Biochem Biophys Res Commun. 2025 Apr 19;765:151857. doi: 10.1016/j.bbrc.2025.151857. Online ahead of print. ABSTRACT OBJECTIVE: To investigate the regulatory role of IP3R2 on mitochondrial function in retinal pigment epithelial cells during the early stage of hypoxic stress preceding apoptosis. METHODS: ARPE-19 cell line was cultured in 1 % oxygen to establish an in vitro hypoxic […]
Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction
Cell Metab. 2025 Apr 18:S1550-4131(25)00211-6. doi: 10.1016/j.cmet.2025.04.001. Online ahead of print. ABSTRACT Heart failure with preserved ejection fraction (HFpEF) is a common cause of morbidity and mortality worldwide, but its pathophysiology remains unclear. Here, we report a mouse model of HFpEF and show that hexokinase (HK)-1 mitochondrial binding in endothelial cells (ECs) is critical for […]
Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):68. doi: 10.1167/iovs.66.4.68. ABSTRACT PURPOSE: We studied the regulatory association of Porphyromonas gingivalis (PG) and cataracts. METHODS: PCR and FISH assays were used for detecting PG 16s ribosomal RNA genome, Immunofluorescence was for expression of RpgA in anterior capsular epithelium and fibrosis markers in anterior subcapsular cataract (ASC) model. […]
Newly Synthesized PW06 Induced Cell Apoptosis in Human Glioblastoma Multiforme GBM 8401 Cells Through Caspase- and Mitochondria-Dependent Pathways
J Biochem Mol Toxicol. 2025 May;39(5):e70264. doi: 10.1002/jbt.70264. ABSTRACT Glioblastoma multiforme (GBM) is the most common, aggressive, and dangerous lethal tumor in the brain, which develops in adults. Currently, the efficiency of chemotherapy treatment for GBM patients is still unsatisfactory. PW06 was synthesized by Dr. Lien’s laboratory (China Medical University, Taichung, Taiwan), and it was […]
SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration
Sci Rep. 2025 Apr 19;15(1):13585. doi: 10.1038/s41598-025-97456-8. ABSTRACT Neurodegenerative diseases of the eye such as optic neuritis (ON) are hallmarked by retinal ganglion cell (RGC) loss and optic nerve degeneration leading to irreversible blindness. Therapeutic interventions enhancing expression or activity of SIRT1, an NAD+-dependent deacetylase, support, at least in part, survival of RGCs in the […]
Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging
Sci Adv. 2025 Apr 18;11(16):eads1842. doi: 10.1126/sciadv.ads1842. Epub 2025 Apr 18. ABSTRACT Decline of mitochondrial respiratory chain (mtRC) capacity is a hallmark of mitochondrial diseases. Patients with mtRC dysfunction often present reduced skeletal growth as a sign of premature cartilage degeneration and aging, but how metabolic adaptations contribute to this phenotype is poorly understood. Here […]
Unraveling the IDH3A: Expanding the Genotypic Spectrum of Macular Pseudocoloboma
Int J Mol Sci. 2025 Apr 3;26(7):3364. doi: 10.3390/ijms26073364. ABSTRACT Disease-causing variants in the IDH3A gene are associated with autosomal recessive retinitis pigmentosa 90 (RP90) and Leber congenital amaurosis, with or without macular pseudocoloboma. Here, we report two patients: one compound heterozygous for IDH3A c.364G>A, p.(Ala122Thr), which has conflicting classifications, and for IDH3A c.293C>T, p.(Pro98Leu), […]