Single-cell analysis of heterogeneity and molecular changes in cultured corneal epithelial stem cells during serial passage
Stem Cells. 2025 Jun 17:sxaf041. doi: 10.1093/stmcls/sxaf041. Online ahead of print. ABSTRACT The maintenance of corneal epithelial homeostasis relies on limbal stem cells (LSCs) located at the limbus. Although short-term cultured LSC transplantation effectively treats LSC deficiency, prolonged culture leads to stemness loss and abortive colony formation, and the mechanisms remain elusive. In this study, […]
Dual effects of erastin on aggressive osteosarcoma cells: ferroptosis sensitization and anti-ferroptotic gene activation
Cytotechnology. 2025 Aug;77(4):128. doi: 10.1007/s10616-025-00795-7. Epub 2025 Jun 23. ABSTRACT Osteosarcoma (OS) is a rare cancer, yet the most prevalent primary bone cancer in adolescents and young adults OS can be fatal and detrimental due to its high aggressiveness, early metastases, and chemo-resistance. Recent research suggests that drugs that induce ferroptosis could treat osteosarcoma. It […]
The Profile of Retinal Ganglion Cell Death and Cellular Senescence in Mice with Aging
Int J Mol Sci. 2025 Jun 6;26(12):5436. doi: 10.3390/ijms26125436. ABSTRACT Older age is a risk factor for glaucoma, in which progressive retinal ganglion cell (RGC) loss leads to visual field defects and irreversible visual impairment and even blindness. We recently identified the involvement of cellular senescence in RGC cell death post-optic nerve injury. Here we […]
New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases
Bioengineering (Basel). 2025 May 23;12(6):563. doi: 10.3390/bioengineering12060563. ABSTRACT The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age. Cellular senescence plays a central role in the aging process and the onset of various eye conditions associated with advancing age, including […]
Postoperative outcomes in mitochondrial myopathy-associated ptosis: a case series
Int Ophthalmol. 2025 Jun 24;45(1):263. doi: 10.1007/s10792-025-03640-0. ABSTRACT PURPOSE: To determine the anatomical and functional success and complication rates after surgical treatment in cases of mitochondrial myopathy (MM) with ptosis and how the complications that develop may be managed. METHODS: Patients who underwent surgical correction due to ptosis between October 2010 and January 2020 and […]
Key challenges and recommendations for defining organelle membrane contact sites
Nat Rev Mol Cell Biol. 2025 Jun 23. doi: 10.1038/s41580-025-00864-x. Online ahead of print. ABSTRACT Intracellular membrane contact sites (MCSs) between organelles have crucial roles in cellular signalling and homeostasis. These sites, which are often disrupted in pathological conditions, enable the exchange of ions, lipids and metabolites between membrane-bound compartments, helping cells adapt to varying […]
Reprogramming Lymphatic Endothelial Glucose Metabolism for the Treatment of Lymphangiogenesis-Related Disease
Pharmacol Res. 2025 Jun 19:107827. doi: 10.1016/j.phrs.2025.107827. Online ahead of print. ABSTRACT Lymphangiogenesis plays important roles in the pathogenesis of several human diseases, including keratitis, transplant rejection, and cancers. Dysregulated glucose metabolism has emerged as a critical driver of pathological lymphangiogenesis. This study aimed to identify novel regulators of this process and elucidate their roles […]
AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Abeta(1-40)-Induced retinal pigment epithelium injury
Cell Commun Signal. 2025 Jun 21;23(1):301. doi: 10.1186/s12964-025-02294-w. ABSTRACT BACKGROUND: The retinal pigment epithelium (RPE) degeneration and subsequent retinal atrophy are hallmarks of age-related macular degeneration (AMD). Amyloid-beta (Aβ), the primary component of amyloid plaques in Alzheimer’s disease (AD), is also present within drusen and is considered a critical factor contributing to RPE degeneration in […]
Seventeen-year follow-up of mitochondrial myopathy and ataxia in a Chinese family: case reports and literature review
Doc Ophthalmol. 2025 Jun 21. doi: 10.1007/s10633-025-10037-y. Online ahead of print. ABSTRACT PURPOSE: To investigate the retinal phenotype and genetic features of a Chinese family with a diagnosis of mitochondrial myopathy and ataxia (MMYAT). METHODS: We conducted a 17-year follow-up of two sisters from a Chinese family and reviewed their medical and family histories. The […]
Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network
Biogerontology. 2025 Jun 20;26(4):123. doi: 10.1007/s10522-025-10268-1. ABSTRACT Excessive exposure of the skin to UV radiaton (UVR) accelerates the aging process and leads to a photoaging state which involves similar pathological alterations to those occurring in chronological aging. UVR exposure, containing both UVA and UVB radiation, triggers cellular senescence and a chronic inflammatory state in skin. […]