Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network
Biogerontology. 2025 Jun 20;26(4):123. doi: 10.1007/s10522-025-10268-1. ABSTRACT Excessive exposure of the skin to UV radiaton (UVR) accelerates the aging process and leads to a photoaging state which involves similar pathological alterations to those occurring in chronological aging. UVR exposure, containing both UVA and UVB radiation, triggers cellular senescence and a chronic inflammatory state in skin. […]
Machine learning to predict mitochondrial diseases by phenotypes
Mitochondrion. 2025 Jun 18:102061. doi: 10.1016/j.mito.2025.102061. Online ahead of print. ABSTRACT Diagnosing mitochondrial diseases remains challenging because of the heterogeneous symptoms. This study aims to use machine learning to predict mitochondrial diseases from phenotypes to reduce genetic testing costs. This study included patients who underwent whole exome or mitochondrial genome sequencing for suspected mitochondrial diseases. […]
Nigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes
FASEB J. 2025 Jun 30;39(12):e70740. doi: 10.1096/fj.202500502R. ABSTRACT The purpose of this study was to examine the nature of the underlying molecular mechanisms of cell death in human keratocytes treated with nigericin, a known pyroptosis inducer. Human keratocytes were exposed to nigericin, and cell death was assessed through morphological analysis and detection of related molecular […]
Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming
Adv Sci (Weinh). 2025 Jun 20:e03690. doi: 10.1002/advs.202503690. Online ahead of print. ABSTRACT Herpes simplex keratitis (HSK) is a leading infectious cause of blindness worldwide, with current therapies primarily targeting viral replication rather than addressing host-cell injury. RNA sequencing of corneal tissue from HSK patients and healthy donors identifies a metabolic shift from mitochondrial oxidative […]
Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target
Neural Regen Res. 2025 Jun 19. doi: 10.4103/NRR.NRR-D-24-01124. Online ahead of print. ABSTRACT The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins. However, if the unfolded protein response fails to restore endoplasmic reticulum homeostasis, it can trigger proinflammatory and […]
Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions
Int J Ophthalmol. 2025 Jun 18;18(6):969-977. doi: 10.18240/ijo.2025.06.01. eCollection 2025. ABSTRACT AIM: To explore the role of a previously-found MYH9 tail domain mutation (p.E1384Q) in the pathogenesis of congenital cataract. METHODS: The cell experiments were conducted in vitro. Wild-type (WT) MYH9 and p.E1384Q mutant fragments were constructed, which was then transiently transfected into Hek293T cell […]
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis
Int J Ophthalmol. 2025 Jun 18;18(6):978-985. doi: 10.18240/ijo.2025.06.02. eCollection 2025. ABSTRACT AIM: To investigate the protective role of ghrelin against diabetic retinopathy (DR), focusing on its anti-ferroptotic mechanism in high glucose-induced retinal endothelial injury. METHODS: First, small interfering RNA (siRNA)-mediated interference was conducted to knockdown nuclear factor erythroid 2-related factor 2 (Nrf2). Using reverse transcription-polymerase […]
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. Online ahead of print. ABSTRACT The emergence of glucagon-like peptide-1 agonists represents a notable advancement in the pharmacological treatment of obesity, yet complementary approaches are essential. Through phenotypic drug discovery, we developed promising nitroalkene-containing small molecules for obesity-related metabolic dysfunctions. Here, we present SANA, a nitroalkene derivative of […]
Mechanisms and Mitochondria-targeted Therapies for Retinal Ganglion Cell Degeneration in Glaucoma
CNS Neurol Disord Drug Targets. 2025 Jun 10. doi: 10.2174/0118715273397014250604050651. Online ahead of print. NO ABSTRACT PMID:40511654 | DOI:10.2174/0118715273397014250604050651
TBCK-Related Neurodevelopmental Disorder
2025 Jun 12. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. ABSTRACT CLINICAL CHARACTERISTICS: TBCK-related neurodevelopmental disorder (TBCK-NDD) is typically a progressive condition in which individuals have significant developmental and respiratory issues. A majority of affected individuals do not achieve […]