Postoperative outcomes in mitochondrial myopathy-associated ptosis: a case series
Int Ophthalmol. 2025 Jun 24;45(1):263. doi: 10.1007/s10792-025-03640-0. ABSTRACT PURPOSE: To determine the anatomical and functional success and complication rates after surgical treatment in cases of mitochondrial myopathy (MM) with ptosis and how the complications that develop may be managed. METHODS: Patients who underwent surgical correction due to ptosis between October 2010 and January 2020 and […]
Key challenges and recommendations for defining organelle membrane contact sites
Nat Rev Mol Cell Biol. 2025 Jun 23. doi: 10.1038/s41580-025-00864-x. Online ahead of print. ABSTRACT Intracellular membrane contact sites (MCSs) between organelles have crucial roles in cellular signalling and homeostasis. These sites, which are often disrupted in pathological conditions, enable the exchange of ions, lipids and metabolites between membrane-bound compartments, helping cells adapt to varying […]
Reprogramming Lymphatic Endothelial Glucose Metabolism for the Treatment of Lymphangiogenesis-Related Disease
Pharmacol Res. 2025 Jun 19:107827. doi: 10.1016/j.phrs.2025.107827. Online ahead of print. ABSTRACT Lymphangiogenesis plays important roles in the pathogenesis of several human diseases, including keratitis, transplant rejection, and cancers. Dysregulated glucose metabolism has emerged as a critical driver of pathological lymphangiogenesis. This study aimed to identify novel regulators of this process and elucidate their roles […]
AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Abeta(1-40)-Induced retinal pigment epithelium injury
Cell Commun Signal. 2025 Jun 21;23(1):301. doi: 10.1186/s12964-025-02294-w. ABSTRACT BACKGROUND: The retinal pigment epithelium (RPE) degeneration and subsequent retinal atrophy are hallmarks of age-related macular degeneration (AMD). Amyloid-beta (Aβ), the primary component of amyloid plaques in Alzheimer’s disease (AD), is also present within drusen and is considered a critical factor contributing to RPE degeneration in […]
Seventeen-year follow-up of mitochondrial myopathy and ataxia in a Chinese family: case reports and literature review
Doc Ophthalmol. 2025 Jun 21. doi: 10.1007/s10633-025-10037-y. Online ahead of print. ABSTRACT PURPOSE: To investigate the retinal phenotype and genetic features of a Chinese family with a diagnosis of mitochondrial myopathy and ataxia (MMYAT). METHODS: We conducted a 17-year follow-up of two sisters from a Chinese family and reviewed their medical and family histories. The […]
Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network
Biogerontology. 2025 Jun 20;26(4):123. doi: 10.1007/s10522-025-10268-1. ABSTRACT Excessive exposure of the skin to UV radiaton (UVR) accelerates the aging process and leads to a photoaging state which involves similar pathological alterations to those occurring in chronological aging. UVR exposure, containing both UVA and UVB radiation, triggers cellular senescence and a chronic inflammatory state in skin. […]
Machine learning to predict mitochondrial diseases by phenotypes
Mitochondrion. 2025 Jun 18:102061. doi: 10.1016/j.mito.2025.102061. Online ahead of print. ABSTRACT Diagnosing mitochondrial diseases remains challenging because of the heterogeneous symptoms. This study aims to use machine learning to predict mitochondrial diseases from phenotypes to reduce genetic testing costs. This study included patients who underwent whole exome or mitochondrial genome sequencing for suspected mitochondrial diseases. […]
Nigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes
FASEB J. 2025 Jun 30;39(12):e70740. doi: 10.1096/fj.202500502R. ABSTRACT The purpose of this study was to examine the nature of the underlying molecular mechanisms of cell death in human keratocytes treated with nigericin, a known pyroptosis inducer. Human keratocytes were exposed to nigericin, and cell death was assessed through morphological analysis and detection of related molecular […]
Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming
Adv Sci (Weinh). 2025 Jun 20:e03690. doi: 10.1002/advs.202503690. Online ahead of print. ABSTRACT Herpes simplex keratitis (HSK) is a leading infectious cause of blindness worldwide, with current therapies primarily targeting viral replication rather than addressing host-cell injury. RNA sequencing of corneal tissue from HSK patients and healthy donors identifies a metabolic shift from mitochondrial oxidative […]
Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target
Neural Regen Res. 2025 Jun 19. doi: 10.4103/NRR.NRR-D-24-01124. Online ahead of print. ABSTRACT The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins. However, if the unfolded protein response fails to restore endoplasmic reticulum homeostasis, it can trigger proinflammatory and […]