High expression of Mrps10 in diabetic retinopathy: A bioinformatics analysis based on public transcriptomic data
Medicine (Baltimore). 2025 Aug 29;104(35):e44179. doi: 10.1097/MD.0000000000044179. ABSTRACT Diabetic retinopathy (DR) is one of the most common microvascular complications in diabetic patients, severely affecting their vision and quality of life. However, the precise molecular mechanisms underlying DR remain unclear. In recent years, mitochondrial ribosomal protein S10 (Mrps10) gene has gained attention due to its high […]
Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link?
Front Neurol. 2025 Aug 13;16:1616992. doi: 10.3389/fneur.2025.1616992. eCollection 2025. ABSTRACT INTRODUCTION: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited condition due to mitochondrial DNA (mtDNA) mutations usually affecting young men within their thirties, while women seem protected by estrogens with a female-to-male ratio of 1:3. Late-onset cases (over 40 years of age) are usually […]
A model for de novo pigmentation of amelanotic retinal pigment epithelial cells
Acta Ophthalmol. 2025 Sep 2. doi: 10.1111/aos.17572. Online ahead of print. ABSTRACT PURPOSE: Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non-pigmented model of ARPE-19 cells […]
Downregulation of the Core Circadian Gene Nr1d2 in the Lacrimal Gland Contributes to Postoperative Dry Eye Disease by Impairing Lipid Metabolism
Ocul Surf. 2025 Aug 28:S1542-0124(25)00109-0. doi: 10.1016/j.jtos.2025.08.009. Online ahead of print. ABSTRACT PURPOSE: Dry eye disease (DED) is a prevalent complication after refractive surgery, and its underlying mechanisms are not fully understood. Given that circadian rhythm tightly regulates tear secretion, this study aims to investigate the circadian changes in the lacrimal gland after corneal refractive […]
Retinal multimodal-imaging and functional tests in a mitochondrial disease with focal and segmental glomerulosclerosis
Int J Ophthalmol. 2025 Sep 18;18(9):1770-1776. doi: 10.18240/ijo.2025.09.19. eCollection 2025. ABSTRACT The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA (m.3243A>G) are highly variable, with different symptoms observed in different patients. These include mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); maternally inherited diabetes and deafness syndrome (MIDD); other syndromic conditions; or […]
Mitochondrial Retinopathy Complicated with Choroidal Neovascularization
Ophthalmol Retina. 2025 Aug 28:S2468-6530(25)00359-8. doi: 10.1016/j.oret.2025.08.001. Online ahead of print. NO ABSTRACT PMID:40879593 | DOI:10.1016/j.oret.2025.08.001
Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function
Elife. 2025 Aug 27;13:RP95887. doi: 10.7554/eLife.95887. ABSTRACT Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), important signaling molecules involved in many cellular processes including Ca2+ release from the endoplasmic reticulum (ER). PLCG1 encodes the PLCγ1 isozyme that is broadly expressed. Hyperactive somatic mutations of PLCG1 are observed in […]
The PERK-p38 MAPK Axis Drives Endoplasmic Reticulum Stress-Induced Apoptosis in Fuchs Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):63. doi: 10.1167/iovs.66.11.63. ABSTRACT PURPOSE: To investigate the role of p38 mitogen-activated protein kinase (MAPK) in endoplasmic reticulum (ER) stress-induced corneal endothelial cell death in Fuchs endothelial corneal dystrophy (FECD) and to evaluate its potential as a therapeutic target. METHODS: Three complementary ER stress models were utilized: (1) FECD […]
In Vivo Reprogramming Dysfunctional Retinal Ganglion Cells and Visual-phototransduction via Wireless Charging Nanogold for Leber’s Hereditary Optic Neuropathy
Adv Mater. 2025 Aug 25:e04509. doi: 10.1002/adma.202504509. Online ahead of print. ABSTRACT Gene therapy offers a promising treatment for Leber’s hereditary optic neuropathy (LHON), a disease of retinal ganglion cell (RGC) degeneration with severe vision loss caused by mitochondria-NADH dehydrogenase 4 (MT-ND4) mutations. However, optimizing mitochondria-targeted gene delivery to promote RGC regeneration and visual-photoreception recovery […]
Mitochondrial Homeostasis in Cancer: Functions and Targeted Therapies
Crit Rev Oncol Hematol. 2025 Aug 21:104899. doi: 10.1016/j.critrevonc.2025.104899. Online ahead of print. ABSTRACT The dysregulation of mitochondrial homeostasis in tumor cells plays a significant role in tumorigenesis and progression. Mitochondria within tumor cells exhibit extensive mutations, proliferation, and fragmentation to accommodate heightened metabolic and energy requirements. This disruption of mitochondrial homeostasis is intricately linked […]