Mechanistic Study of the Novel Peroxidase Mimetic DhHP-6 in Metabolic Cataracts
Free Radic Biol Med. 2025 Jul 2:S0891-5849(25)00805-6. doi: 10.1016/j.freeradbiomed.2025.07.001. Online ahead of print. ABSTRACT Metabolic disorders such as diabetes and high-galactose often induce oxidative damage and mitochondrial dysfunction in the lens, leading to metabolic cataracts. Although surgical intervention remains the primary treatment, its associated risks and complications underscore the need for pharmacological alternatives with multifaceted […]
SHMT2 overexpression improves glaucoma by enhancing mitophagy in retinal ganglion cells through promoting the phospho of PINK1
Diagn Pathol. 2025 Jul 2;20(1):79. doi: 10.1186/s13000-025-01675-6. ABSTRACT BACKGROUND: Glaucoma is a major eye disease that causes blindness. The loss of retinal ganglion cells (RGCs) due to mitophagy impairment is a key driver of glaucoma. SHMT2 depletion leads to an increase in reactive oxygen species (ROS), but its role in regulating mitophagy remains unclear. This […]
Bi-allelic loss-of-function variants in POC5 cause a syndromic retinal, endocrine and neuromuscular ciliopathy
Genet Med. 2025 Jun 28:101513. doi: 10.1016/j.gim.2025.101513. Online ahead of print. ABSTRACT PURPOSE: A homozygous loss-of-function (LoF) variant in POC5 centriolar protein (POC5) was previously described in an individual with retinitis pigmentosa. We identified POC5 variants in twelve probands with a syndromic phenotype. We aim to define the phenotype spectrum and molecular mechanism associated with […]
Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches
Front Immunol. 2025 Jun 16;16:1571576. doi: 10.3389/fimmu.2025.1571576. eCollection 2025. ABSTRACT Diabetic retinopathy (DR) is a common and severe microvascular complication of diabetes, leading to vision impairment and blindness, particularly in working-age adults. Oxidative stress plays a central role in the pathogenesis of DR, with excessive reactive oxygen species (ROS) damaging retinal tissues, including blood vessels […]
Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma
Transl Vis Sci Technol. 2025 Jun 2;14(6):37. doi: 10.1167/tvst.14.6.37. ABSTRACT PURPOSE: The primary objective of this study is to comprehensively investigate the genetic association between mitochondrial gene expression, methylation, and primary open-angle glaucoma (POAG) using Mendelian randomization (MR) analysis. METHODS: In this study, mitochondrial-related genes and methylation sites were extracted from two expression quantitative trait […]
Virus-Inspired Nanoparticles for Intensified Cancer Therapy via Cascade Reinforcement of “Nontoxicity-to-Toxicity” Transition and Mitochondrial Dysfunction
Adv Healthc Mater. 2025 Jun 26:e2405274. doi: 10.1002/adhm.202405274. Online ahead of print. ABSTRACT Mitochondria play an essential role in cellular oxidative stress defense. Mitochondrial impairment results in disrupted intracellular redox balance and tumor cell apoptosis. Herein, a biodegradable nanoprobe for combination chemotherapy is constructed by developing a virus-like mesoporous copper oxide nanocage co-loaded with disulfiram […]
Single-cell analysis of heterogeneity and molecular changes in cultured corneal epithelial stem cells during serial passage
Stem Cells. 2025 Jun 17:sxaf041. doi: 10.1093/stmcls/sxaf041. Online ahead of print. ABSTRACT The maintenance of corneal epithelial homeostasis relies on limbal stem cells (LSCs) located at the limbus. Although short-term cultured LSC transplantation effectively treats LSC deficiency, prolonged culture leads to stemness loss and abortive colony formation, and the mechanisms remain elusive. In this study, […]
Dual effects of erastin on aggressive osteosarcoma cells: ferroptosis sensitization and anti-ferroptotic gene activation
Cytotechnology. 2025 Aug;77(4):128. doi: 10.1007/s10616-025-00795-7. Epub 2025 Jun 23. ABSTRACT Osteosarcoma (OS) is a rare cancer, yet the most prevalent primary bone cancer in adolescents and young adults OS can be fatal and detrimental due to its high aggressiveness, early metastases, and chemo-resistance. Recent research suggests that drugs that induce ferroptosis could treat osteosarcoma. It […]
The Profile of Retinal Ganglion Cell Death and Cellular Senescence in Mice with Aging
Int J Mol Sci. 2025 Jun 6;26(12):5436. doi: 10.3390/ijms26125436. ABSTRACT Older age is a risk factor for glaucoma, in which progressive retinal ganglion cell (RGC) loss leads to visual field defects and irreversible visual impairment and even blindness. We recently identified the involvement of cellular senescence in RGC cell death post-optic nerve injury. Here we […]
New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases
Bioengineering (Basel). 2025 May 23;12(6):563. doi: 10.3390/bioengineering12060563. ABSTRACT The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age. Cellular senescence plays a central role in the aging process and the onset of various eye conditions associated with advancing age, including […]