Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions
Int J Ophthalmol. 2025 Jun 18;18(6):969-977. doi: 10.18240/ijo.2025.06.01. eCollection 2025. ABSTRACT AIM: To explore the role of a previously-found MYH9 tail domain mutation (p.E1384Q) in the pathogenesis of congenital cataract. METHODS: The cell experiments were conducted in vitro. Wild-type (WT) MYH9 and p.E1384Q mutant fragments were constructed, which was then transiently transfected into Hek293T cell […]
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis
Int J Ophthalmol. 2025 Jun 18;18(6):978-985. doi: 10.18240/ijo.2025.06.02. eCollection 2025. ABSTRACT AIM: To investigate the protective role of ghrelin against diabetic retinopathy (DR), focusing on its anti-ferroptotic mechanism in high glucose-induced retinal endothelial injury. METHODS: First, small interfering RNA (siRNA)-mediated interference was conducted to knockdown nuclear factor erythroid 2-related factor 2 (Nrf2). Using reverse transcription-polymerase […]
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. Online ahead of print. ABSTRACT The emergence of glucagon-like peptide-1 agonists represents a notable advancement in the pharmacological treatment of obesity, yet complementary approaches are essential. Through phenotypic drug discovery, we developed promising nitroalkene-containing small molecules for obesity-related metabolic dysfunctions. Here, we present SANA, a nitroalkene derivative of […]
Mechanisms and Mitochondria-targeted Therapies for Retinal Ganglion Cell Degeneration in Glaucoma
CNS Neurol Disord Drug Targets. 2025 Jun 10. doi: 10.2174/0118715273397014250604050651. Online ahead of print. NO ABSTRACT PMID:40511654 | DOI:10.2174/0118715273397014250604050651
TBCK-Related Neurodevelopmental Disorder
2025 Jun 12. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. ABSTRACT CLINICAL CHARACTERISTICS: TBCK-related neurodevelopmental disorder (TBCK-NDD) is typically a progressive condition in which individuals have significant developmental and respiratory issues. A majority of affected individuals do not achieve […]
The Role of Endothelial Senescence in the Pathogenesis of Diabetic Retinopathy
Int J Mol Sci. 2025 May 29;26(11):5211. doi: 10.3390/ijms26115211. ABSTRACT Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). Key drivers of DR include mitochondrial dysfunction, oxidative stress, and chronic inflammation, which lead to premature senescence of cells within the retinal vasculature. Senolytics improve outcomes in both animal models and in […]
Nitric Oxide may Adversely Affect the Metabolism and Viability of Retinal Organoids Derived from Patients with Leber Hereditary Optic Neuropathy
Am J Pathol. 2025 Jun 9:S0002-9440(25)00188-9. doi: 10.1016/j.ajpath.2025.05.006. Online ahead of print. ABSTRACT Leber hereditary optic neuropathy (LHON) is a bilateral optic neuropathy associated with mitochondrial DNA (mtDNA) mutations characterized by parapapillary telangiectasia during the acute phase. However, its precise mechanism remains unclear. This study evaluated the effects of nitric oxide (NO) on retinal organoids […]
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Signal Transduct Target Ther. 2025 Jun 11;10(1):190. doi: 10.1038/s41392-025-02253-4. ABSTRACT Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces an imbalance between oxidation and antioxidation, mitochondrial DNA (mtDNA) damage, mitochondrial dynamics dysregulation, and changes […]
Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation
Comput Struct Biotechnol J. 2025 May 14;27:1962-1974. doi: 10.1016/j.csbj.2025.05.013. eCollection 2025. ABSTRACT Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of corneal transplantation globally. Despite evidence of mitochondrial abnormalities in KC, the underlying mechanisms remain unclear. Our aim was to investigate the role of mitochondrial dysfunction in this pathological condition. Based […]
Autologous Serum from Sjögren’s Syndrome Patients Mitigates Ferroptosis in Hyperosmolarity-Induced Corneal Epitheliopathy
J Ocul Pharmacol Ther. 2025 Jun 11. doi: 10.1089/jop.2025.0025. Online ahead of print. ABSTRACT Purpose: To investigate the role of autologous serum (AS) in alleviating hyperosmolarity-induced corneal epitheliopathy via the ferroptosis pathway. Methods: AS was extracted and prepared from patients with Sjögren’s syndrome. An in vitro hyperosmotic dry eye model was established by exposing HCE-T […]