Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Müller Cells of the Diabetic Neural Retina by Modulating ACSL4
J Diabetes Res. 2025 Aug 13;2025:1924668. doi: 10.1155/jdr/1924668. eCollection 2025. ABSTRACT Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by early neuronal damage in the retina, termed diabetic neuropathy in the retina (DNR). This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to […]
Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma
BMJ Open Ophthalmol. 2025 Aug 21;10(1):e002126. doi: 10.1136/bmjophth-2024-002126. ABSTRACT OBJECTIVE: Glaucoma is a common neurodegenerative disease resulting in irreversible blindness. This study investigates whether fucoxanthin can safeguard retinal ganglion cells (RGCs) by modulating Parkin-mediated mitophagy in experimental glaucoma. METHODS: An experimental glaucomatous model was induced in Sprague-Dawley rats via translimbal laser photocoagulation. Intraocular pressure (IOP) […]
The intersection of mitochondria, lipids, and ferroptosis: a new avenue for dry age-related macular degeneration
Apoptosis. 2025 Aug 21. doi: 10.1007/s10495-025-02165-2. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is currently the leading cause of vision loss in developed countries. Despite decades of research and development, there are currently no treatments for the dry version of the illness. Dry AMD (DAMD) is a multifactorial disease stemming from dysfunction in […]
Mitochondrial Homeostasis Dysfunctions During the Epithelial-Mesenchymal Transition Process in Lens Epithelial Cells
Exp Eye Res. 2025 Aug 18:110583. doi: 10.1016/j.exer.2025.110583. Online ahead of print. ABSTRACT Lens epithelial cells (LECs), the main mitochondria-containing cells in the lens, play a vital role in maintaining lens transparency. Mitochondrial homeostasis is essential for cellular function, yet its changes during epithelial-mesenchymal transition (EMT) in LECs remain unclear. In this study, EMT was […]
Early-Onset Sensorimotor Axonal Neuropathy as Sole Manifestation of HADHA-Related Disorder/ Mitochondrial Trifunctional Protein Defect
J Child Neurol. 2025 Aug 17:8830738251356850. doi: 10.1177/08830738251356850. Online ahead of print. ABSTRACT Pathogenic variants in the HADHA and HADHB genes are associated with impairment of mitochondrial trifunctional protein. Mitochondrial trifunctional protein deficiency is a disorder of long-chain fatty acid oxidation with different clinical presentations: the neonatal-onset form expressing with severe cardiac phenotype, the infantile-onset […]
Targeting LARP1 to mitigate aging in Lens epithelial cells: mechanistic insights into mitochondrial dysfunction
Exp Eye Res. 2025 Aug 14:110582. doi: 10.1016/j.exer.2025.110582. Online ahead of print. ABSTRACT As we age, lens epithelial cells (LECs) undergo various stressors, contributing to cataract development. Targeting the regulation of mitochondrial metabolism may be an effective strategy to delay LEC aging. La-related protein 1 (LARP1) is an RNA-binding protein that affects mitochondrial function by […]
Metabolomic insights into vitreous humor with therapy outcome in type 2 diabetic retinopathy
BMC Ophthalmol. 2025 Aug 15;25(1):460. doi: 10.1186/s12886-025-04283-6. ABSTRACT BACKGROUND: The therapeutic outcome for Type 2 Diabetic Retinopathy (T2DR) following vitrectomy has been unsatisfactory, with no definitive biomarker available to predict treatment response. Identifying a biomarker correlated with treatment efficacy is crucial, as the vitreous-situated between the lens and retina-may influence retinal metabolic perturbations. METHODS: Vitreous […]
MTHFD2 Drives Retinoblastoma Progression via Notch Signaling Activation: Implications for Targeted Pediatric Ocular Cancer Therapy
Exp Eye Res. 2025 Aug 13:110579. doi: 10.1016/j.exer.2025.110579. Online ahead of print. ABSTRACT Retinoblastoma (RB), the most prevalent intraocular malignancy in children, severely threatens vision and survival, yet therapeutic strategies for recurrent or refractory RB remain limited. MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2), one of the key enzymes involved in mitochondrial one-carbon metabolism, is aberrantly overexpressed in […]
Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival
J Biol Chem. 2025 Aug 12:110586. doi: 10.1016/j.jbc.2025.110586. Online ahead of print. ABSTRACT Mutations in the mitochondrial respiratory complex I accessory subunit NADH:ubiquinone oxidoreductase subunit S4 (ndufs4) can cause the mitochondrial disease Leigh syndrome, which may be associated with vision loss. We previously demonstrated that mice with global deletion of ndufs4 exhibited impaired in vivo […]
Resveratrol as a Novel Therapeutic Approach for Diabetic Retinopathy: Molecular Mechanisms, Clinical Potential, and Future Challenges
Molecules. 2025 Aug 4;30(15):3262. doi: 10.3390/molecules30153262. ABSTRACT Diabetic retinopathy (DR) is a progressive, multifactorial complication of diabetes and one of the major global causes of visual impairment. Its pathogenesis involves chronic hyperglycaemia-induced oxidative stress, inflammation, mitochondrial dysfunction, neurodegeneration, and pathological angiogenesis, as well as emerging systemic contributors such as gut microbiota dysregulation. While current treatments, […]