Absolute quantification of TCA cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism
bioRxiv [Preprint]. 2025 Sep 27:2025.09.25.678562. doi: 10.1101/2025.09.25.678562. ABSTRACT OBJECTIVE: Mitochondrial tricarboxylic acid (TCA) cycle is central to energy production and redox balance in the eye, which must sustain high metabolic activity to support vision. Retinal neurons, the retinal pigment epithelium (RPE), cornea, and lens each have distinct physiological roles and metabolic demands, yet the absolute […]
Exploring rare mitochondrial DNA in Leber hereditary optic neuropathy
Adv Ophthalmol Pract Res. 2025 Aug 22;5(4):278-284. doi: 10.1016/j.aopr.2025.08.001. eCollection 2025 Nov-Dec. ABSTRACT BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder primarily caused by mutations in MT-ND1, MT-ND4, and MT-ND6, leading to retinal ganglion cell degeneration and severe vision loss. While 90%-95% of cases involve three common mutations (m.11778G > A, […]
Ferroptosis and organelle roles in dry eye
iScience. 2025 Sep 9;28(10):113527. doi: 10.1016/j.isci.2025.113527. eCollection 2025 Oct 17. ABSTRACT Dry eye, an ocular surface disorder, has become increasingly prevalent over the past few years due to air pollution and stress in daily life. Emerging studies on dry eye in both cellular and animal models indicate changes in ferroptosis-related markers. Furthermore, mitochondrial dysfunction, endoplasmic […]
Genetically predicted causal links between gut microbiota and biological aging phenotypes in age-related macular degeneration
Biogerontology. 2025 Oct 13;26(6):191. doi: 10.1007/s10522-025-10329-5. ABSTRACT Current knowledge regarding the role of gut microbiota (GM) dysbiosis and biological aging in the pathogenesis of age-related macular degeneration (AMD) remains limited. This study aims to explore the causal relationships among these factors in AMD development. Utilizing two-sample bidirectional mendelian randomization (MR), we analyzed genome-wide association study […]
Vitamin abnormalities in neuropathic corneal pain
Eye Vis (Lond). 2025 Oct 12;12(1):39. doi: 10.1186/s40662-025-00457-x. ABSTRACT Neuropathic corneal pain (NCP) refers to spontaneous corneal pain in the absence of stimuli arising from corneal nerve dysfunction with no clinically observable ocular surface abnormalities. It is debilitating with difficult-to-manage symptoms-burning pain, photophobia, and irritation being profound. However, evidence-based clinical recommendations for the management of […]
Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway
J Nanobiotechnology. 2025 Oct 10;23(1):657. doi: 10.1186/s12951-025-03706-2. ABSTRACT Radiation-induced cataracts (RIC), a significant cause of blindness, arise from oxidative damage and inflammation in the lens epithelium, and there has been a lack of effective targeted therapeutic drugs in clinic. Here, we proposed and developed a novel approach for prevention and treatment of RIC via multifunctional […]
KIF11-related MCLMR presenting with FEVR-like retinopathy: first report in an Indian child
Ophthalmic Genet. 2025 Oct 9:1-4. doi: 10.1080/13816810.2025.2572708. Online ahead of print. ABSTRACT INTRODUCTION: KIF11 gene mutations can result in a rare autosomal dominant inheritable disease called microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR/MLCRD). Recently, such mutations were also found to be associated with familial exudative vitreoretinopathy (FEVR). METHODS: Retrospective case report. RESULTS: […]
Prosapogenin CP4 exacerbates mitophagy to induce apoptosis via AMPK-mTOR and PINK1/Parkin pathways in A549 cells
Phytomedicine. 2025 Sep 28;148:157333. doi: 10.1016/j.phymed.2025.157333. Online ahead of print. ABSTRACT BACKGROUND: Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality worldwide. While mitophagy, a process that selectively removes damaged mitochondria, typically promotes cell survival, its excessive activation can trigger apoptosis, offering a novel therapeutic avenue. In this study, we report for […]
Visual Recovery in Leber’s Hereditary Optic Neuropathy Plus: A Case Report and Literature Insight
Case Rep Ophthalmol. 2025 Aug 28;16(1):686-692. doi: 10.1159/000547946. eCollection 2025 Jan-Dec. ABSTRACT INTRODUCTION: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder that primarily affects young men, leading to subacute, painless, bilateral loss of central vision. It is caused by point mutations in mitochondrial DNA, especially those involving the MT-ND1, MT-ND4, and MT-ND6 […]
Polydatin’s neuroprotective mechanism in optic nerve injury: targeting mitochondrial function and glial cell activation
Exp Eye Res. 2025 Oct 6:110685. doi: 10.1016/j.exer.2025.110685. Online ahead of print. ABSTRACT Optic nerve injury (ONI) frequently causes irreversible visual impairment, making it a significant clinical challenge. This study evaluated the neuroprotective effects of polydatin (PD), focusing on its ability to preserve mitochondrial function and inhibit glial cell activation. We utilized an in vitro […]