Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism
J Adv Res. 2025 Jul 28:S2090-1232(25)00573-9. doi: 10.1016/j.jare.2025.07.044. Online ahead of print. ABSTRACT INTRODUCTION: Fungal infections represent a global health concern with significant implications for human well-being. Among them, refractory and sight-threatening fungal keratitis (FK) poses a serious threat to ocular health. This underscores an urgent need for developing novel antifungal agents to meet clinical […]
Mitochondrial Disorder: Kearns-Sayre Syndrome
Adv Exp Med Biol. 2025;1467:173-175. doi: 10.1007/978-3-031-72230-1_30. ABSTRACT Mitochondrial DNA (mtDNA) deletions can be identified, and rarely point mutation. PMID:40736832 | DOI:10.1007/978-3-031-72230-1_30
Drug-Induced Retinal Toxicity
Adv Exp Med Biol. 2025;1467:253-262. doi: 10.1007/978-3-031-72230-1_50. ABSTRACT Despite the protective blood-ocular barrier, various drugs can induce retinal damage, manifesting as retinal pigment epithelium dysfunction, photoreceptor degeneration, vascular abnormalities, ganglion cell damage, optic nerve impairment, or uveitis. These toxic effects are often linked to mechanisms such as oxidative stress, mitochondrial dysfunction, and cytoskeletal disruption. Early […]
Mitochondrial Disorder: Maternally Inherited Diabetes and Deafness
Adv Exp Med Biol. 2025;1467:177-180. doi: 10.1007/978-3-031-72230-1_31. ABSTRACT Patients with maternally inherited diabetes and deafness (MIDD) have insulin-dependent diabetes with relatively low BMI; usually the onset of the diabetes is during the third or fourth decade of life and it is associated with progressive neurosensory deafness. PMID:40736833 | DOI:10.1007/978-3-031-72230-1_31
Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration
Commun Biol. 2025 Jul 29;8(1):1118. doi: 10.1038/s42003-025-08565-z. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of central vision impairment among the elderly. Geographic atrophy is a defining characteristic of AMD, but the detailed mechanism for massive loss of retinal pigment epithelium (RPE) cells is not fully understood. In this study, we found that Z-DNA […]
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis
Drug Des Devel Ther. 2025 Jul 22;19:6219-6233. doi: 10.2147/DDDT.S523455. eCollection 2025. ABSTRACT INTRODUCTION: Alectinib is a widely used first-line ALK inhibitor for fusion-positive non-small cell lung cancer. However, its clinical use is limited by hepatotoxicity, and its mechanism remains unclear. This study aims to elucidate how alectinib induces liver injury and to explore a potential […]
Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration
ACS Omega. 2025 Jul 7;10(28):30467-30488. doi: 10.1021/acsomega.5c02227. eCollection 2025 Jul 22. ABSTRACT Age-related macular degeneration (AMD) is a progressive, late-onset, genetic (CFH, HTRA), and environmental (smoking, aging) ocular disease that is a leading cause of blindness affecting more than 200 million people worldwide. New treatments are required for fibrosis, autophagy, and microglia-driven pathologies in AMD […]
Roles of 670 nm Photobiomodulation on Rat Anterior Ischemic Optic Neuropathy: Enhancing RGC Survival, Mitochondrial Function, and Anti-Inflammatory Response
Antioxidants (Basel). 2025 Jul 18;14(7):886. doi: 10.3390/antiox14070886. ABSTRACT Non-arteritic anterior ischemic optic neuropathy (NAION) leads to retinal ganglion cell (RGC) loss and visual impairment, with no effective treatment. This study investigated the neuroprotective effect of 670 nm photobiomodulation (PBM) in a rat NAION model (rNAION). Wistar rats received 670 nm light exposure (10-min, 3000 lux) […]
Effect of Hypoxia on Adult Müller Glia Cultures
Biomedicines. 2025 Jul 16;13(7):1743. doi: 10.3390/biomedicines13071743. ABSTRACT Background: The retina, a light-sensitive tissue of the central nervous system that is located at the posterior part of the eye, is particularly vulnerable to alterations in oxygen levels. In various retinal diseases, such as central retinal vein occlusion, glaucoma, and diabetic retinopathy, hypoxia (a condition of low […]
SIRT1 Alleviates Hyperglycemia-induced Oxidative Stress and Dysfunction of Limbal Niche Cells by Deacetylating FOXO1
Free Radic Biol Med. 2025 Jul 24:S0891-5849(25)00847-0. doi: 10.1016/j.freeradbiomed.2025.07.032. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is a major cause of vision loss, with a complex pathogenesis. In particular, the mechanisms by which hyperglycemia affects the limbal remain unclear. The purpose of this study was to investigate the impact of hyperglycemia on oxidative stress […]