Effect of Hypoxia on Adult Müller Glia Cultures
Biomedicines. 2025 Jul 16;13(7):1743. doi: 10.3390/biomedicines13071743. ABSTRACT Background: The retina, a light-sensitive tissue of the central nervous system that is located at the posterior part of the eye, is particularly vulnerable to alterations in oxygen levels. In various retinal diseases, such as central retinal vein occlusion, glaucoma, and diabetic retinopathy, hypoxia (a condition of low […]
SIRT1 Alleviates Hyperglycemia-induced Oxidative Stress and Dysfunction of Limbal Niche Cells by Deacetylating FOXO1
Free Radic Biol Med. 2025 Jul 24:S0891-5849(25)00847-0. doi: 10.1016/j.freeradbiomed.2025.07.032. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is a major cause of vision loss, with a complex pathogenesis. In particular, the mechanisms by which hyperglycemia affects the limbal remain unclear. The purpose of this study was to investigate the impact of hyperglycemia on oxidative stress […]
Rhodiola tangutica (Maxim.) S. H. Fu protects blood-retinal barrier in hypoxia-induced retinal injury rats by down-regulating HIF-1α/eNOS/NO pathway
J Ethnopharmacol. 2025 Jul 24:120325. doi: 10.1016/j.jep.2025.120325. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Rhodiola tangutica (Maxim.) S. H. Fu (TS) (RT), as a traditional Tibetan medicine, has been used for treating acute and chronic mountain sickness in Qinghai Province of China for a long time. High altitude retinopathy (HAR), exposed to acute hypobaric hypoxia, […]
Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development
Cells. 2025 Jul 17;14(14):1097. doi: 10.3390/cells14141097. ABSTRACT Intrauterine growth restriction (IUGR) is a critical challenge in perinatal medicine and is associated with significant morbidity and mortality. This review explores the intricate involvement of early developmental senescence in IUGR. We highlight the dual role of cellular senescence in both normal development and pathological conditions, emphasizing the […]
Fundus Autofluorescence in Inherited Retinal Disease: A Review
Cells. 2025 Jul 16;14(14):1092. doi: 10.3390/cells14141092. ABSTRACT Fundus autofluorescence (FAF) is a non-invasive retinal imaging technique that helps visualize naturally occurring fluorophores, such as lipofuscin, and provides valuable insight into retinal diseases-particularly inherited retinal diseases (IRDs). FAF is especially useful in detecting subclinical or early-stage IRDs and in monitoring disease progression over time. In Stargardt […]
Recent Advances in Targeted Immunomodulatory Therapies for Chronic Ocular Surface Diseases
Semin Ophthalmol. 2025 Jul 25:1-13. doi: 10.1080/08820538.2025.2536766. Online ahead of print. ABSTRACT PURPOSE: To review and compare the mechanisms of action, clinical efficacy, and safety profiles of topical immunosuppressive and immunomodulatory agents for the management of chronic ocular surface diseases. METHODS: A comprehensive review of the literature was conducted using PubMed, Scopus, and Web of […]
Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
Stem Cell Res Ther. 2025 Jul 25;16(1):397. doi: 10.1186/s13287-025-04509-w. ABSTRACT BACKGROUND: Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cells (PRPCs) offers potential for vision restoration. However, substantial early donor cell loss remains a major challenge. This study aims to […]
Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice
Pharmacol Res. 2025 Jul 23:107877. doi: 10.1016/j.phrs.2025.107877. Online ahead of print. ABSTRACT Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with both n-3 DHA […]
Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
Cell Rep Med. 2025 Jul 16:102244. doi: 10.1016/j.xcrm.2025.102244. Online ahead of print. ABSTRACT Mutations in the tripeptidyl peptidase 1 (TPP1) gene lead to neuronal ceroid lipofuscinosis type 2 (CLN2), characterized by lysosomal accumulation of lipofuscins predominantly in the brain and retina. The ocular phenotype is characterized by outer retinal degeneration that leads to vision loss. […]
Developmental Endothelial Locus 1 Reduces Traumatic Brain Injury-Induced Endotheliopathy and Dysregulated Coagulation in Mice
Arterioscler Thromb Vasc Biol. 2025 Jul 24. doi: 10.1161/ATVBAHA.125.322515. Online ahead of print. ABSTRACT BACKGROUND: Traumatic brain injury (TBI) induces endothelial injury (endotheliopathy) that disrupts the vascular barrier to cause cerebral hemorrhage and inflammation and allows the release of extracellular vesicles (EVs) from injured brain cells into the circulation. These EVs are highly procoagulant, causing […]