Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults
Front Med (Lausanne). 2025 Dec 1;12:1596799. doi: 10.3389/fmed.2025.1596799. eCollection 2025. ABSTRACT BACKGROUND: Age-related eye diseases are the main causes of progressive and irreversible vision loss in aging populations worldwide. Carotenoids, as a group of common natural antioxidants, can suppress free radicals produced by complex physiological reactions, thereby protecting the eyes from the effects of oxidative […]
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells
Aging Dis. 2025 Dec 15. doi: 10.14336/AD.2025.1221. Online ahead of print. ABSTRACT Thyroid hormone (TH) signaling regulates cellular metabolism and stress response in the retina. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. Furthermore, stimulation of TH signaling induces retinal degeneration in mice, which is accompanied by the […]
Full recovery of vision following early and intensive hemodialysis in an 18-year-old woman with methylmalonic acidemia-related optic neuropathy
Mol Genet Metab Rep. 2025 Nov 27;45:101279. doi: 10.1016/j.ymgmr.2025.101279. eCollection 2025 Dec. ABSTRACT BACKGROUND: Methylmalonic acidemia (MMA) caused by complete or partial deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (mut0 or mut- enzymatic subtype, respectively) leads to the accumulation of toxic organic acids, causing severe organ dysfunction and life-threatening complications. Despite appropriate treatment, optic neuropathy […]
Endothelial mitochondrial-derived vesicles (EMDVs) with retinal targeted homing properties dynamically modulate the eIF2alpha-ATF4-CHOP signaling pathway and efficiently restore mitochondrial homeostasis in diabetic retina
J Nanobiotechnology. 2025 Dec 14. doi: 10.1186/s12951-025-03929-3. Online ahead of print. NO ABSTRACT PMID:41392137 | DOI:10.1186/s12951-025-03929-3
Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission
Int Immunopharmacol. 2025 Dec 12;169:116019. doi: 10.1016/j.intimp.2025.116019. Online ahead of print. ABSTRACT BACKGROUND: Pro-inflammatory macrophage function is linked to an increase in mitochondrial fission. Melatonin has a positive impact on atherosclerosis and has a significant effect on the control of mitochondrial fission and fusion. Nevertheless, it is still unclear how melatonin contributes to slowing the […]
Retinal Ganglion Cell Diversity in Disease: Clinical Implications and Type-Specific Evaluation
J Neuroophthalmol. 2025 Sep 1;45(3):350-361. doi: 10.1097/WNO.0000000000002381. ABSTRACT BACKGROUND: Retinal ganglion cells (RGCs) are diverse. Various types play specialized roles in vision, and they may be differentially susceptible in optic nerve disease where their death causes vision loss. RGCs are accordingly compelling targets for novel therapeutic strategies, and so it is clinically imperative to be […]
Honokiol (HNK) accelerates corneal epithelial wound healing by promoting HMGCS2-mediated mitochondrial metabolic homeostasis
Exp Eye Res. 2025 Dec 9:110805. doi: 10.1016/j.exer.2025.110805. Online ahead of print. ABSTRACT Corneal epithelial regeneration is critical for restoring ocular surface function after injury. This study investigated the therapeutic potential and molecular mechanism of honokiol (HNK) in promoting corneal epithelial repair. Using a murine corneal epithelial debridement model, we observed that HNK accelerated wound […]
Autophagy and Mitophagy in Diabetic Retinopathy: The Effects and Mechanism of Action on the Neurovascular Unit
Exp Eye Res. 2025 Dec 9:110802. doi: 10.1016/j.exer.2025.110802. Online ahead of print. ABSTRACT While diabetic retinopathy (DR) is the primary cause of vision impairment and blindness in people with diabetes, current treatments fail to target early pathogenic mechanisms to halt disease progression. The development of DR involves complex cellular stress responses associated with metabolic dysregulation. […]
Targeting endothelial mitochondrial dynamics in glaucoma: A novel therapeutic opportunity
Mol Ther. 2025 Dec 10:S1525-0016(25)01022-6. doi: 10.1016/j.ymthe.2025.11.036. Online ahead of print. NO ABSTRACT PMID:41380675 | DOI:10.1016/j.ymthe.2025.11.036
Combination of YAP inhibition and photodynamic therapy induces dual DNA damage and activates STING pathway to enhance immunotherapy in uveal melanoma
Redox Biol. 2025 Dec 6;89:103965. doi: 10.1016/j.redox.2025.103965. Online ahead of print. ABSTRACT Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and is highly aggressive, with no therapies shown to improve overall survival. Although immunotherapy achieves response rates of 33-40 % in advanced cutaneous melanoma, its efficacy in UM is disappointingly low, […]