Acute Bilateral Vision Loss in a Young Male: A Case of Leber’s Hereditary Optic Neuropathy
Cureus. 2025 Jun 23;17(6):e86607. doi: 10.7759/cureus.86607. eCollection 2025 Jun. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is a rare mitochondrial genetic disorder that primarily affects young adult males, leading to acute or subacute painless central vision loss. The condition results from point mutations in mitochondrial DNA, most commonly affecting the ND1, ND4, or ND6 genes, which […]
Berberine Inhibits High Glucose-Induced Ferroptosis in Retinal Vascular Endothelial Cells: Mechanism and Implications
Exp Eye Res. 2025 Jul 21:110531. doi: 10.1016/j.exer.2025.110531. Online ahead of print. ABSTRACT This study investigates ferroptosis in human retinal microvascular endothelial cells (HRMECs) under high-glucose conditions and explores the therapeutic potential of Berberine (BBR) in mitigating this process. Using Western blotting and RT-qPCR, we observed that prolonged high glucose (48h) significantly downregulated GPX4 and […]
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy
Int Immunopharmacol. 2025 Jul 22;163:115240. doi: 10.1016/j.intimp.2025.115240. Online ahead of print. ABSTRACT To identify platelet-related biomarkers in diabetic retinopathy (DR) and clarify the role of lymphocyte cytosolic protein 2 (LCP2) and the PD-1/PD-L1 pathway in DR pathogenesis, we employed STZ-induced diabetic rats and a high-glucose (HG) T cell-RPE cell co-culture model. Platelet-related genes were screened […]
IL-1β-Mediated Immunometabolic Adaptation in Corneal Epithelial Cells
J Inflamm Res. 2025 Jul 18;18:9537-9555. doi: 10.2147/JIR.S495323. eCollection 2025. ABSTRACT PURPOSE: As an external mucosal surface, the corneal epithelium is subject to a barrage of stressors that are known to trigger inflammation. IL-1β, a master regulator of inflammation, is secreted into the preocular tear film by ocular surface epithelial cells and infiltrating immune cells. […]
CD38-NAD(+) Axis: New Insights into Glaucoma Therapy
Mol Neurobiol. 2025 Jul 22. doi: 10.1007/s12035-025-05243-3. Online ahead of print. ABSTRACT Glaucoma is a globally recognized leading cause of irreversible blindness, and its progression is closely associated with retinal ganglion cell (RGC) degeneration and mitochondrial dysfunction. Recently, there has been growing interest in the role of nicotinamide adenine dinucleotide (NAD +) and its regulatory […]
TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function
Clin Ophthalmol. 2025 Jul 16;19:2343-2362. doi: 10.2147/OPTH.S521660. eCollection 2025. ABSTRACT BACKGROUND: Recent studies have demonstrated that mitochondrial dysfunction is pivotal in early diabetic retinopathy (DR). Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis. METHODS: We established in vivo and in vitro models of DR. Hematoxylin and […]
Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression
Mater Today Bio. 2025 Jul 4;33:102052. doi: 10.1016/j.mtbio.2025.102052. eCollection 2025 Aug. ABSTRACT The breakdown of the blood-retinal barrier (BRB), which induces vascular leakage, represents a critical pathological hallmark underlying severe vision loss in uveitis. The inflammatory response triggers phenotypic alterations in microglia, driving excessive reactive oxygen species (ROS) production and initiating a pro-inflammatory cytokine storm […]
Artemisinin synergizes with CCCP in autophagic cell death induction via ER stress in uveal melanoma
iScience. 2025 Jun 21;28(8):112972. doi: 10.1016/j.isci.2025.112972. eCollection 2025 Aug 15. ABSTRACT Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and it is associated with a poor prognosis due to the lack of effective targeted therapies. Artemisinin (ARS), a widely used antimalarial drug, has demonstrated anti-tumor effects in several types of cancer, […]
Sex differences on laser-induced choroidal neovascularization and short-chain fatty acid treatment in a mouse model
J Neuroinflammation. 2025 Jul 19;22(1):188. doi: 10.1186/s12974-025-03508-1. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of blindness worldwide, with a clinical presentation that varies between sexes. In late-stage AMD, choroidal neovascularization (CNV) triggers retinal inflammation and degeneration, processes that are exacerbated by an overactive response of retinal microglial cells. Short-chain fatty acids (SCFAs) have […]
NDUFV1 mutation presenting as isolated progressive optic neuropathy: a unique manifestation of mitochondrial complex I deficiency
BMJ Case Rep. 2025 Jul 18;18(7):e266155. doi: 10.1136/bcr-2025-266155. ABSTRACT Mutations in the NDUFV1 gene, encoding a subunit of mitochondrial complex I, are typically associated with severe neurological disorders such as Leigh syndrome. We report a pre-teen girl with progressive bilateral optic atrophy and steady visual deterioration, without neurological findings or systemic involvement. Neuroimaging was unremarkable […]