Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In Vivo
Int J Mol Sci. 2025 Dec 4;26(23):11746. doi: 10.3390/ijms262311746. ABSTRACT Oxidative-stress-induced neuronal injury is a major contributor to neurodegenerative diseases, underscoring the need for novel neuroprotective strategies. Natural products with antioxidant and mitochondrial-stabilizing properties are increasingly recognized as promising multi-target therapeutics. Ficus benjamina L., a member of the Moraceae family, is rich in flavonoids and […]
Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative Mechanisms
Int J Mol Sci. 2025 Nov 28;26(23):11539. doi: 10.3390/ijms262311539. ABSTRACT Inherited retinal degenerations (IRDs), driven by pathogenic mutations, often involve primary dysfunction of the retinal pigment epithelium (RPE)-a pathogenic feature shared with atrophic age-related macular degeneration (aAMD), despite aAMD’s multifactorial etiology. Prominin-1 (Prom1), traditionally linked to photoreceptor pathology, has an unclear role in RPE homeostasis. […]
Dietary restriction-responsive genes define prognostic subtypes and predict metastasis in colorectal cancer
Transl Cancer Res. 2025 Nov 30;14(11):7790-7809. doi: 10.21037/tcr-2025-1329. Epub 2025 Nov 26. ABSTRACT BACKGROUND: Colorectal cancer (CRC) is a major cause of cancer-related death, with a poor prognosis often due to metastasis and recurrence. Dietary restriction (DR) is known to delay tumor progression and extend lifespan, but the roles of dietary restriction-responsive genes (DRRGs) in […]
Ocular Toxicity and Mechanistic Investigation for Berberine and Its Metabolite Berberrubine on Zebrafish
Molecules. 2025 Nov 30;30(23):4602. doi: 10.3390/molecules30234602. ABSTRACT Berberine (BBR) has seen growing application in ophthalmology, yet the ocular toxicity of BBR and its metabolites remains poorly understood. This study aimed to evaluate the ocular toxicity of BBR and its major metabolite M1 and unravel their underlying mechanisms. Ocular toxicity was evaluated in human corneal epithelial […]
SIRT3 deficiency exacerbates cognitive decline by disrupting mitochondrial antioxidant homeostasis in D-galactose-induced aging mice
J Transl Med. 2025 Dec 10. doi: 10.1186/s12967-025-07495-y. Online ahead of print. ABSTRACT BACKGROUND: Age-related cognitive decline poses a growing clinical burden, with mitochondrial oxidative stress recognized as a key mediator. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, is a potential regulator of redox balance, but its role in hippocampal function and cognitive aging, particularly its […]
CRISPR/Cas12a coupled with MIRA: A specific and rapid assay for human DNA in challenging forensic matrices
Forensic Sci Int Genet. 2025 Dec 8;82:103393. doi: 10.1016/j.fsigen.2025.103393. Online ahead of print. ABSTRACT Human DNA detection is crucial in forensic medicine, particularly for trace, degraded, or mixed samples, which demand high sensitivity, specificity, and rapid processing. Traditional methods, such as immunological assays and PCR-based techniques, often suffer from operational complexity, limited sensitivity, or high […]
Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models
BMC Complement Med Ther. 2025 Dec 9. doi: 10.1186/s12906-025-05215-z. Online ahead of print. ABSTRACT BACKGROUND: Parkinson’s disease (PD) is becoming increasingly prevalent worldwide. The pathophysiology of this condition is characterized by oxidative stress, inflammation, iron accumulation, mitochondrial dysfunction, and protein aggregation, all of which contribute to cell death and neurodegeneration. Microglia, the innate immune cells […]
Serum neuronal, glial and mitochondrial markers in autosomal dominant optic atrophy and Leber hereditary optic neuropathy
Brain Commun. 2025 Nov 17;7(6):fcaf446. doi: 10.1093/braincomms/fcaf446. eCollection 2025. ABSTRACT Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (ADOA) are the two most prevailing primary mitochondrial optic neuropathies. Both diseases preferentially affect the smallest retinal ganglion cells (GCs) of the papillomacular bundle, causing central visual loss in young patients. Although ADOA and LHON show […]
Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus
World J Stem Cells. 2025 Nov 26;17(11):111162. doi: 10.4252/wjsc.v17.i11.111162. ABSTRACT Type 2 diabetes mellitus, particularly when accompanied by obesity, has become a major global public health burden. Visceral adipose tissue accumulation contributes to insulin resistance, lipotoxicity, and chronic inflammation, thereby accelerating metabolic deterioration. Although pharmacological agents such as pioglitazone and metformin are effective in modulating […]
Protective Effects of Standardized Peucedanum Japonicum Thunb. Extract Against UVB-Induced Corneal Epithelial Apoptosis via Mitochondrial Regulation
Front Biosci (Landmark Ed). 2025 Nov 27;30(11):46498. doi: 10.31083/FBL46498. ABSTRACT BACKGROUND: Ultraviolet B (UVB) irradiation is a major environmental factor causing corneal epithelial cell apoptosis, leading to ocular surface damage and vision impairment. OBJECTIVE: This study aimed to investigate whether the standardized extract of Peucedanum japonicum Thunb. (SBP) protects corneal cells from UVB-induced apoptosis and […]