Mitogenomic architecture and phylogenetic placement of Ctenophthalmus yunnanus and Frontopsylla diqingensis: insights from comparative genomics
Front Vet Sci. 2025 Oct 29;12:1683581. doi: 10.3389/fvets.2025.1683581. eCollection 2025. ABSTRACT Fleas are among the most common hematophagous ectoparasites of mammals. In addition to causing allergic dermatitis and anemia, they can transmit various pathogens. Currently, molecular data on fleas remain relatively scarce. This study sequenced the complete mitochondrial genomes of Ctenophthalmus yunnanus (first mitogenome reported) […]
The roles of glycerophospholipids in the aging retina and age-related macular degeneration
Graefes Arch Clin Exp Ophthalmol. 2025 Nov 13. doi: 10.1007/s00417-025-07011-4. Online ahead of print. ABSTRACT Glycerophospholipids (GPs) are integral constituents of cellular membranes, and play a crucial role in the regulation of lipid metabolism homeostasis and physiological conditions. However, pathological alterations associated with aging, such as variations in plasma GP concentrations, disruptions in intercellular GP […]
Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity
Nutrients. 2025 Oct 25;17(21):3357. doi: 10.3390/nu17213357. ABSTRACT Background/Objectives: Photobiomodulation (PBM) is a non-invasive, low-level laser treatment shown to improve insulin resistance, glucose metabolism, and obesity-related inflammation. This study examined whether PBM could acutely enhance mitochondrial efficiency and energy metabolism in women with obesity. Methods: In a randomized, crossover within-subject design, 16 women with obesity (43 […]
Aging and Corneal Nerve Health: Mechanisms of Degeneration and Emerging Therapies for the Cornea
Cells. 2025 Nov 4;14(21):1730. doi: 10.3390/cells14211730. ABSTRACT Corneal nerves play a crucial role in maintaining ocular surface homeostasis by supporting the functional integrity of corneal epithelial, stromal, and endothelial cells; modulating tear secretion; and facilitating sensory responses essential for overall ocular health. With advancing age, these highly specialized peripheral sensory fibers undergo progressive attrition and […]
Therapeutic Modulation of the Nox2-Hv1-ROS Axis by Botulinum Neurotoxin A Confers Protection Against CoCl2-Induced Retinal Hypoxic Injury
Int J Mol Sci. 2025 Nov 6;26(21):10806. doi: 10.3390/ijms262110806. ABSTRACT Neuroinflammation and oxidative stress are key drivers of various ocular diseases. Experimental hypoxia, modeled using cobalt chloride (CoCl2), induces hypoxia-inducible factor 1-alpha (HIF-1α) stabilization, mitochondrial dysfunction, and excessive reactive oxygen species (ROS) production, primarily via the NADPH oxidase 2 (Nox2)-voltage-gated proton channel Hv1 axis. Although […]
Update on Nicotinamide and Its Application in the Management of Glaucoma
Int J Mol Sci. 2025 Nov 6;26(21):10789. doi: 10.3390/ijms262110789. ABSTRACT Glaucoma continues to be a primary contributor to permanent vision loss worldwide, frequently advancing even when intraocular pressure management is clinically adequate. Accumulating research emphasizes the metabolic susceptibility of retinal ganglion cells (RGCs), specifically concerning the progressive depletion of nicotinamide adenine dinucleotide (NAD+), a pivotal […]
Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives
Int J Mol Sci. 2025 Nov 3;26(21):10699. doi: 10.3390/ijms262110699. ABSTRACT Dry eye disease (DED) is a highly prevalent multifactorial disorder of the ocular surface that extends beyond local tear film pathology to involve systemic immune, neuroendocrine, and neurosensory mechanisms. Increasing evidence reveals a strong and bidirectional association between DED and psychiatric disorders, particularly depression, anxiety, […]
Diet, Exercise, and Lifestyle in Glaucoma: Current Evidence and Future Perspectives
Nutrients. 2025 Oct 27;17(21):3369. doi: 10.3390/nu17213369. ABSTRACT Glaucoma is a major ocular neurodegenerative disease and a leading cause of irreversible blindness worldwide, with prevalence projected to exceed 110 million by 2040. Although lowering intraocular pressure (IOP) remains the only proven treatment, glaucoma arises from a complex interplay of genetic, local, and systemic factors-including oxidative stress, […]
Molecular mechanisms of 10-butyl ether minocycline, a novel nonantibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders
J Pharmacol Exp Ther. 2025 Oct 10;392(11):103748. doi: 10.1016/j.jpet.2025.103748. Online ahead of print. ABSTRACT The pleiotropy of minocycline (MINO), including anti-inflammatory, antioxidant, antimigratory, anti-matrix metalloproteinase (MMP), and neuroprotective effects, has been extensively reported. A novel nonantibiotic MINO derivative, 10-butyl ether minocycline (BEM), was synthesized to retain the pleiotropy of MINO while minimizing side effects such […]
Kyphoscoliosis peptidase deficiency-induced myofibrillar degeneration, focal depletion of mitochondria, and protein aggregation: A true myofibrillar myopathy?
J Neuromuscul Dis. 2025 Nov 12:22143602251387026. doi: 10.1177/22143602251387026. Online ahead of print. ABSTRACT Homozygous KY variants have been described to cause congenital myopathy, myofibrillar myopathy type 7, and hereditary spastic paraplegia. We report the findings in two families harboring the homozygous missense NM_178554.4:c.727T > C p.(Cys243Arg) and splice site NM_178554.4:c.710 + 1G > A KY […]