FLIM-guided self-reporting of PDT efficacy using a mitochondria-targeted, viscosity-sensitive quinolinium probe
J Mater Chem B. 2025 Oct 22. doi: 10.1039/d5tb01668a. Online ahead of print. ABSTRACT Mitochondrial viscosity plays a pivotal role in the microenvironment of mitochondria and is closely associated with pathological conditions. As a light-activated treatment for cancer and infections, photodynamic therapy (PDT) relies on reactive oxygen species (ROS) generation by photosensitizers to induce cell […]
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction
Signal Transduct Target Ther. 2025 Oct 22;10(1):350. doi: 10.1038/s41392-025-02448-9. ABSTRACT Proliferative diabetic retinopathy (PDR) is a major complication of diabetes characterized by pathological angiogenesis in the retina. Standard treatment includes vitrectomy to remove these abnormal vessels, and the resulting clinical specimens provide an opportunity to define drivers of PDR. Here, we profiled endothelial and immune […]
The Emerging Role of Metabolic Interventions in Uveal Melanoma
Semin Cancer Biol. 2025 Oct 17:S1044-579X(25)00126-9. doi: 10.1016/j.semcancer.2025.10.002. Online ahead of print. ABSTRACT Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, presenting significant clinical challenges due to its aggressive nature and metastatic potential, which results in poor prognosis in some patients. Despite recent therapeutic advances, the survival rate for metastatic UM […]
Lights-on for Cardiovascular Disease: Can Red and Near Infrared Light Treatment Help the Recovery Process?
Ann Biomed Eng. 2025 Oct 17. doi: 10.1007/s10439-025-03884-y. Online ahead of print. ABSTRACT Two of the most common, often fatal, forms of cardiovascular disease are acute myocardial infarction and stroke. Both conditions involve compromised blood flow to target organs, resulting in dysfunction and subsequent death of cardiac and brain cells. Unfortunately, treatment options aiding the […]
Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced retinal pigment epithelium degeneration in mice
J Transl Med. 2025 Oct 15;23(1):1103. doi: 10.1186/s12967-025-07195-7. ABSTRACT BACKGROUND: Disruption of the retinoid (visual) cycle causes all-trans-retinal (atRAL) to accumulate in photoreceptors and retinal pigment epithelium (RPE), contributing to Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (dAMD). Yet, the mechanisms underlying atRAL-induced RPE degeneration are not well understood. Here, we explored […]
Population-specific polygenic risk scores for people of Han Chinese ancestry
Nature. 2025 Oct 15. doi: 10.1038/s41586-025-09350-y. Online ahead of print. ABSTRACT Predicting complex disease risks on the basis of individual genomic profiles is an advancing field in human genetics1,2. However, most genetic studies have focused on populations of European ancestry, creating a global imbalance in precision medicine and underscoring the need for genomic research in […]
Enhanced mitochondria-associated membrane formation in Fuchs endothelial corneal dystrophy: a novel link between endoplasmic reticulum stress and mitochondrial dysfunction
Jpn J Ophthalmol. 2025 Oct 15. doi: 10.1007/s10384-025-01288-y. Online ahead of print. ABSTRACT PURPOSE: To investigate the presence and characteristics of mitochondria-associated membranes (MAMs) in Fuchs endothelial corneal dystrophy (FECD) and to assess the relationship between endoplasmic reticulum (ER) stress and MAM formation in corneal endothelial cells, given the established roles of mitochondrial dysfunction and […]
The Role of ARL13B in Mitochondrial Homeostasis in Cultured Human Corneal Endothelial Cells
Invest Ophthalmol Vis Sci. 2025 Oct 1;66(13):25. doi: 10.1167/iovs.66.13.25. ABSTRACT PURPOSE: The purpose of this study was to investigate the relationship between primary cilia and mitochondrial function in cultured human corneal endothelial cells (HCECs). METHODS: HCECs obtained from donor corneas were cultured and categorized into either differentiated cells or cell-state transition (CST) cells based on […]
Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients
Curr Eye Res. 2025 Oct 14:1-8. doi: 10.1080/02713683.2025.2570815. Online ahead of print. ABSTRACT PURPOSE: To investigate the possible contribution of nitrosative stress, mitochondrial peptide levels (humanin and mitochondrial open-reading frame of the 12S rRNA-c), and ferroptosis parameters in corneal epithelial cells obtained from patients with keratoconus. METHODS: This prospective study was conducted on corneal epithelial […]
Choroidal neovascularization in a teenager with Kearns Sayre syndrome
Ophthalmic Genet. 2025 Oct 14:1-2. doi: 10.1080/13816810.2025.2572711. Online ahead of print. ABSTRACT BACKGROUND: Kearns Sayre syndrome (KSS) is a rare multisystem mitochondrial disorder. KSS primarily targets energy supply in cells through impaired oxidative metabolism and reduced ATP (Adenosine triphosphate) production. KSS is clinically characterized by a classic triad of chronic progressive external ophthalmoplegia, retinitis pigmentosa […]