‘Adrift From the World’: Exploring the Lived Experiences of Individuals Affected by an Inherited Optic Neuropathy in the United Kingdom – A Qualitative Study
Value Health. 2025 Aug 5:S1098-3015(25)02490-8. doi: 10.1016/j.jval.2025.07.023. Online ahead of print. ABSTRACT OBJECTIVES: Little is understood about the lived experiences of individuals affected by inherited optic neuropathies (IONs) in the United Kingdom. The aim of this study was to understand how autosomal dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON), the two more […]
Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis
Transl Vis Sci Technol. 2025 Aug 1;14(8):13. doi: 10.1167/tvst.14.8.13. ABSTRACT PURPOSE: This study aims to understand the differences in cellular and molecular patterns between the Main and Accessory (Acc) regions of pterygium tissue, with a focus on inflammation and mitochondrial energy metabolism. METHODS: We collected bulk RNA sequencing (RNA-seq) data from six pterygium patients and […]
Metformin in Diabetic Retinopathy: Mechanisms, Therapeutic Potential, and Barriers
Cureus. 2025 Jul 7;17(7):e87455. doi: 10.7759/cureus.87455. eCollection 2025 Jul. ABSTRACT The primary aim of diabetic retinopathy (DR) management is to prevent or slow the decline of vision loss. While current treatments for DR are effective in the advanced stages, they may not be as effective in the early phases of the disease. Metformin is among […]
Natural History and Biomarker Challenges in Dominant Optic Atrophy: Implications for Therapeutic Studies
Clin Exp Ophthalmol. 2025 Aug;53(6):597-599. doi: 10.1111/ceo.14583. NO ABSTRACT PMID:40765395 | DOI:10.1111/ceo.14583
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells
Structure. 2025 Jul 25:S0969-2126(25)00258-8. doi: 10.1016/j.str.2025.07.010. Online ahead of print. ABSTRACT Combining three-dimensional (3D) visualization with elemental analysis of vitrified cells can provide crucial insights into subcellular structures and elemental compositions in their native environments. We present a coordinated approach using cryogenic electron energy loss spectroscopy (cryoEELS) and cryogenic electron tomography (cryoET) to characterize the […]
Construction and characteristics of an adjustable biomechanical in vitro corneal stromal model simulating keratoconus pathological features
Mater Today Bio. 2025 Jul 23;34:102130. doi: 10.1016/j.mtbio.2025.102130. eCollection 2025 Oct. ABSTRACT Keratoconus (KC) is a prevalent ectatic corneal disease influenced by corneal biomechanics, though its pathogenesis remains unclear. Constructing an in vitro corneal model with adjustable biomechanics is essential for studying keratoconus. In this study, a KC disease group (L group) was created using […]
MiRNA-122-5p Promotes Retinal Ganglion Cell Oxidative Damage by Targeting DJ-1 in Hyperglycemic Retina
Free Radic Biol Med. 2025 Aug 2:S0891-5849(25)00869-X. doi: 10.1016/j.freeradbiomed.2025.07.054. Online ahead of print. ABSTRACT Mitochondrial dysfunction, induced by prolonged hyperglycemia, is widely regarded as a central factor in oxidative stress and retinal ganglion cell (RGC) degeneration in diabetic retinopathy (DR). DJ-1 (PARK7) acts as a crucial antioxidant defense mechanism, stabilizing mitochondrial structure and redox balance. […]
Adipose-derived mesenchymal stem cells and retinal pigment epithelial cells interactions in a stress environment via tunneling nanotubes
PLoS One. 2025 Aug 4;20(8):e0329672. doi: 10.1371/journal.pone.0329672. eCollection 2025. ABSTRACT This study aims to demonstrate the formation of tunneling tubes (TNTs) between adipose-derived mesenchymal stem cells (AdMSCs) and retinal pigment epithelial cells (RPE-1) and their alterations in response to experimental stress conditions. Serum starvation was employed as a stress condition to induce TNTs between the […]
Digitalization of surgical features improves surgical accuracy via surgeon guidance and robotization
NPJ Digit Med. 2025 Aug 2;8(1):497. doi: 10.1038/s41746-025-01887-6. ABSTRACT The evolution of surgical techniques aims to augment surgeons’ capabilities through digital guidance and robotization for higher precision and consistency. Currently, surgeries heavily rely on surgeon’s experience and visual judgment, causing operation variations. Artificial intelligence (AI) offers a solution by extracting and digitizing surgical trajectories and […]
IVF add-ons: effectiveness, efficiency, safety, and additional costs – A position statement by the SIFES-MR
Eur J Obstet Gynecol Reprod Biol. 2025 Jul 29;313:114609. doi: 10.1016/j.ejogrb.2025.114609. Online ahead of print. ABSTRACT OBJECTIVE: To critically appraise IVF add-ons, based on current evidence, international recommendations, and expert consensus from SIFES-MR. STUDY DESIGN: Consensus developed by a multidisciplinary panel of Italian reproductive medicine experts over two years, based on clinical expertise, revision of […]