Targeting LARP1 to mitigate aging in Lens epithelial cells: mechanistic insights into mitochondrial dysfunction
Exp Eye Res. 2025 Aug 14:110582. doi: 10.1016/j.exer.2025.110582. Online ahead of print. ABSTRACT As we age, lens epithelial cells (LECs) undergo various stressors, contributing to cataract development. Targeting the regulation of mitochondrial metabolism may be an effective strategy to delay LEC aging. La-related protein 1 (LARP1) is an RNA-binding protein that affects mitochondrial function by […]
Metabolomic insights into vitreous humor with therapy outcome in type 2 diabetic retinopathy
BMC Ophthalmol. 2025 Aug 15;25(1):460. doi: 10.1186/s12886-025-04283-6. ABSTRACT BACKGROUND: The therapeutic outcome for Type 2 Diabetic Retinopathy (T2DR) following vitrectomy has been unsatisfactory, with no definitive biomarker available to predict treatment response. Identifying a biomarker correlated with treatment efficacy is crucial, as the vitreous-situated between the lens and retina-may influence retinal metabolic perturbations. METHODS: Vitreous […]
MTHFD2 Drives Retinoblastoma Progression via Notch Signaling Activation: Implications for Targeted Pediatric Ocular Cancer Therapy
Exp Eye Res. 2025 Aug 13:110579. doi: 10.1016/j.exer.2025.110579. Online ahead of print. ABSTRACT Retinoblastoma (RB), the most prevalent intraocular malignancy in children, severely threatens vision and survival, yet therapeutic strategies for recurrent or refractory RB remain limited. MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2), one of the key enzymes involved in mitochondrial one-carbon metabolism, is aberrantly overexpressed in […]
Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival
J Biol Chem. 2025 Aug 12:110586. doi: 10.1016/j.jbc.2025.110586. Online ahead of print. ABSTRACT Mutations in the mitochondrial respiratory complex I accessory subunit NADH:ubiquinone oxidoreductase subunit S4 (ndufs4) can cause the mitochondrial disease Leigh syndrome, which may be associated with vision loss. We previously demonstrated that mice with global deletion of ndufs4 exhibited impaired in vivo […]
Resveratrol as a Novel Therapeutic Approach for Diabetic Retinopathy: Molecular Mechanisms, Clinical Potential, and Future Challenges
Molecules. 2025 Aug 4;30(15):3262. doi: 10.3390/molecules30153262. ABSTRACT Diabetic retinopathy (DR) is a progressive, multifactorial complication of diabetes and one of the major global causes of visual impairment. Its pathogenesis involves chronic hyperglycaemia-induced oxidative stress, inflammation, mitochondrial dysfunction, neurodegeneration, and pathological angiogenesis, as well as emerging systemic contributors such as gut microbiota dysregulation. While current treatments, […]
Glaucoma-associated Optineurin mutations increase transcellular degradation of mitochondria in a vertebrate optic nerve
Elife. 2025 Aug 12;14:e103844. doi: 10.7554/eLife.103844. Online ahead of print. ABSTRACT We previously described a process whereby mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of mice. Since the mitophagy receptor Optineurin (OPTN) is one of few large-effect glaucoma genes and axonal […]
0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia
Sci Rep. 2025 Aug 11;15(1):29392. doi: 10.1038/s41598-025-12800-2. ABSTRACT Myopia is the most widespread refractive error caused by an increase in the axial length (AL) of the eyeball, and is also a major risk factor for other blinding eye diseases, seriously endangering human health and quality of life. Investigating practical methods to control the progression of […]
Technological advances in the diagnosis and management of inherited optic neuropathies
Front Neurol. 2025 Jul 25;16:1609033. doi: 10.3389/fneur.2025.1609033. eCollection 2025. ABSTRACT Preferential degeneration of retinal ganglion cells (RGCs) is a defining feature of the inherited optic neuropathies (IONs), a group of monogenic eye diseases predominately comprising Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA). Their pathogenesis is characterised by mitochondrial dysfunction, which causes […]
hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis
J Mol Histol. 2025 Aug 9;56(4):264. doi: 10.1007/s10735-025-10535-y. ABSTRACT OBJECTIVE: Diabetic retinopathy (DR) is a leading cause of vision loss, driven by hyperglycemia-induced human retinal microvascular endothelial cell (HRMEC) dysfunction, mitochondrial impairment, oxidative stress, inflammation, and aberrant angiogenesis. Circular RNAs (circRNAs) have emerged as critical regulators in various ocular pathologies, yet their contributions to DR […]
Unlocking the potential of GLP-1 receptor agonists in ocular therapeutics: from molecular pathways to clinical impact
Front Pharmacol. 2025 Jul 24;16:1618079. doi: 10.3389/fphar.2025.1618079. eCollection 2025. ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for diabetes and obesity, exhibit pleiotropic effects-including anti-inflammatory, antioxidant, and neuroprotective properties-that position them as transformative candidates for ocular therapeutics. Ocular diseases such as glaucoma and diabetic retinopathy (DR) are driven by multifactorial pathogenesis. Current therapies often target […]