Mitochondrial Retinopathy Complicated with Choroidal Neovascularization
Ophthalmol Retina. 2025 Aug 28:S2468-6530(25)00359-8. doi: 10.1016/j.oret.2025.08.001. Online ahead of print. NO ABSTRACT PMID:40879593 | DOI:10.1016/j.oret.2025.08.001
Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function
Elife. 2025 Aug 27;13:RP95887. doi: 10.7554/eLife.95887. ABSTRACT Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), important signaling molecules involved in many cellular processes including Ca2+ release from the endoplasmic reticulum (ER). PLCG1 encodes the PLCγ1 isozyme that is broadly expressed. Hyperactive somatic mutations of PLCG1 are observed in […]
The PERK-p38 MAPK Axis Drives Endoplasmic Reticulum Stress-Induced Apoptosis in Fuchs Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):63. doi: 10.1167/iovs.66.11.63. ABSTRACT PURPOSE: To investigate the role of p38 mitogen-activated protein kinase (MAPK) in endoplasmic reticulum (ER) stress-induced corneal endothelial cell death in Fuchs endothelial corneal dystrophy (FECD) and to evaluate its potential as a therapeutic target. METHODS: Three complementary ER stress models were utilized: (1) FECD […]
In Vivo Reprogramming Dysfunctional Retinal Ganglion Cells and Visual-phototransduction via Wireless Charging Nanogold for Leber’s Hereditary Optic Neuropathy
Adv Mater. 2025 Aug 25:e04509. doi: 10.1002/adma.202504509. Online ahead of print. ABSTRACT Gene therapy offers a promising treatment for Leber’s hereditary optic neuropathy (LHON), a disease of retinal ganglion cell (RGC) degeneration with severe vision loss caused by mitochondria-NADH dehydrogenase 4 (MT-ND4) mutations. However, optimizing mitochondria-targeted gene delivery to promote RGC regeneration and visual-photoreception recovery […]
Mitochondrial Homeostasis in Cancer: Functions and Targeted Therapies
Crit Rev Oncol Hematol. 2025 Aug 21:104899. doi: 10.1016/j.critrevonc.2025.104899. Online ahead of print. ABSTRACT The dysregulation of mitochondrial homeostasis in tumor cells plays a significant role in tumorigenesis and progression. Mitochondria within tumor cells exhibit extensive mutations, proliferation, and fragmentation to accommodate heightened metabolic and energy requirements. This disruption of mitochondrial homeostasis is intricately linked […]
Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Müller Cells of the Diabetic Neural Retina by Modulating ACSL4
J Diabetes Res. 2025 Aug 13;2025:1924668. doi: 10.1155/jdr/1924668. eCollection 2025. ABSTRACT Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by early neuronal damage in the retina, termed diabetic neuropathy in the retina (DNR). This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to […]
Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma
BMJ Open Ophthalmol. 2025 Aug 21;10(1):e002126. doi: 10.1136/bmjophth-2024-002126. ABSTRACT OBJECTIVE: Glaucoma is a common neurodegenerative disease resulting in irreversible blindness. This study investigates whether fucoxanthin can safeguard retinal ganglion cells (RGCs) by modulating Parkin-mediated mitophagy in experimental glaucoma. METHODS: An experimental glaucomatous model was induced in Sprague-Dawley rats via translimbal laser photocoagulation. Intraocular pressure (IOP) […]
The intersection of mitochondria, lipids, and ferroptosis: a new avenue for dry age-related macular degeneration
Apoptosis. 2025 Aug 21. doi: 10.1007/s10495-025-02165-2. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is currently the leading cause of vision loss in developed countries. Despite decades of research and development, there are currently no treatments for the dry version of the illness. Dry AMD (DAMD) is a multifactorial disease stemming from dysfunction in […]
Mitochondrial Homeostasis Dysfunctions During the Epithelial-Mesenchymal Transition Process in Lens Epithelial Cells
Exp Eye Res. 2025 Aug 18:110583. doi: 10.1016/j.exer.2025.110583. Online ahead of print. ABSTRACT Lens epithelial cells (LECs), the main mitochondria-containing cells in the lens, play a vital role in maintaining lens transparency. Mitochondrial homeostasis is essential for cellular function, yet its changes during epithelial-mesenchymal transition (EMT) in LECs remain unclear. In this study, EMT was […]
Early-Onset Sensorimotor Axonal Neuropathy as Sole Manifestation of HADHA-Related Disorder/ Mitochondrial Trifunctional Protein Defect
J Child Neurol. 2025 Aug 17:8830738251356850. doi: 10.1177/08830738251356850. Online ahead of print. ABSTRACT Pathogenic variants in the HADHA and HADHB genes are associated with impairment of mitochondrial trifunctional protein. Mitochondrial trifunctional protein deficiency is a disorder of long-chain fatty acid oxidation with different clinical presentations: the neonatal-onset form expressing with severe cardiac phenotype, the infantile-onset […]