Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation
Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2502483122. doi: 10.1073/pnas.2502483122. Epub 2025 Sep 5. ABSTRACT Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows […]
Dimethyl fumarate is an inhibitor of pathological angiogenesis
Cell Signal. 2025 Sep 2:112106. doi: 10.1016/j.cellsig.2025.112106. Online ahead of print. ABSTRACT Vascular endothelial growth factor (VEGF), a pro-angiogenic molecule, supports blood vessel growth during wound healing but also drives pathological neovascularization in blinding eye diseases such as neovascular age-related macular degeneration (nAMD). Dimethyl fumarate (DMFu), an FDA-approved drug for multiple sclerosis, has previously shown […]
Metformin may alter the course of Leber’s hereditary optic neuropathy: a case report
Front Med (Lausanne). 2025 Aug 19;12:1609941. doi: 10.3389/fmed.2025.1609941. eCollection 2025. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a rare inherited mitochondrial disease caused by variants in mitochondrial DNA (mtDNA) transmitted exclusively through the maternal line. The disease predominantly affects young males and is characterized by progressive bilateral vision loss. Idebenone, a well-studied drug, modestly enhances […]
Oxidative stress-related biomarkers in thyroid eye disease: evidence from bioinformatics analysis and experimental validation
Front Immunol. 2025 Aug 18;16:1635712. doi: 10.3389/fimmu.2025.1635712. eCollection 2025. ABSTRACT BACKGROUND: Oxidative stress is a key contributor to the pathogenesis of the autoimmune condition thyroid eye disease (TED). However, its precise molecular mechanisms and reliable biomarkers remain unclear. Bioinformatics enables the identification of differentially expressed genes through transcriptomic analysis. However, distinguishing truly relevant findings from […]
The Therapeutic Potential of Flavonols in Alzheimer’s Disease: Inhibiting Amyloid-β, Oxidative Stress, and Neuroinflammation
Biofactors. 2025 Sep-Oct;51(5):e70047. doi: 10.1002/biof.70047. ABSTRACT Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) aggregation, oxidative stress, and neuroinflammation, remains a significant global health challenge. This study investigates the therapeutic potential of flavonols-quercetin, kaempferol, myricetin, and fisetin-in targeting Aβ aggregation and mitigating AD pathology through diverse molecular mechanisms. Our findings reveal that […]
High expression of Mrps10 in diabetic retinopathy: A bioinformatics analysis based on public transcriptomic data
Medicine (Baltimore). 2025 Aug 29;104(35):e44179. doi: 10.1097/MD.0000000000044179. ABSTRACT Diabetic retinopathy (DR) is one of the most common microvascular complications in diabetic patients, severely affecting their vision and quality of life. However, the precise molecular mechanisms underlying DR remain unclear. In recent years, mitochondrial ribosomal protein S10 (Mrps10) gene has gained attention due to its high […]
Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link?
Front Neurol. 2025 Aug 13;16:1616992. doi: 10.3389/fneur.2025.1616992. eCollection 2025. ABSTRACT INTRODUCTION: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited condition due to mitochondrial DNA (mtDNA) mutations usually affecting young men within their thirties, while women seem protected by estrogens with a female-to-male ratio of 1:3. Late-onset cases (over 40 years of age) are usually […]
A model for de novo pigmentation of amelanotic retinal pigment epithelial cells
Acta Ophthalmol. 2025 Sep 2. doi: 10.1111/aos.17572. Online ahead of print. ABSTRACT PURPOSE: Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non-pigmented model of ARPE-19 cells […]
Downregulation of the Core Circadian Gene Nr1d2 in the Lacrimal Gland Contributes to Postoperative Dry Eye Disease by Impairing Lipid Metabolism
Ocul Surf. 2025 Aug 28:S1542-0124(25)00109-0. doi: 10.1016/j.jtos.2025.08.009. Online ahead of print. ABSTRACT PURPOSE: Dry eye disease (DED) is a prevalent complication after refractive surgery, and its underlying mechanisms are not fully understood. Given that circadian rhythm tightly regulates tear secretion, this study aims to investigate the circadian changes in the lacrimal gland after corneal refractive […]
Retinal multimodal-imaging and functional tests in a mitochondrial disease with focal and segmental glomerulosclerosis
Int J Ophthalmol. 2025 Sep 18;18(9):1770-1776. doi: 10.18240/ijo.2025.09.19. eCollection 2025. ABSTRACT The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA (m.3243A>G) are highly variable, with different symptoms observed in different patients. These include mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); maternally inherited diabetes and deafness syndrome (MIDD); other syndromic conditions; or […]