Transketolase regulates endoplasmic reticulum stress independent of enzymatic activity in human retinal Müller cells
Exp Eye Res. 2025 Nov 6:110732. doi: 10.1016/j.exer.2025.110732. Online ahead of print. ABSTRACT Transketolase (TKT) expression in the nucleus of the retina has been reported, but its function beyond metabolism remains unclear. In this study, we investigated the role of TKT in the regulation of endoplasmic reticulum (ER) stress in the retina. Using a VEGF-overexpressing […]
Dihydroartemisinin: A Targeting Agent of CCT3-Mediated Oxidative Stress to Enhance the Antitumor Activity of Doxorubicin in Hepatocellular Carcinoma
Dig Dis Sci. 2025 Nov 8. doi: 10.1007/s10620-025-09503-z. Online ahead of print. ABSTRACT BACKGROUND: Liver cancer is the third most common cause of cancer-related death after lung and colorectal cancers. Hepatocellular carcinoma (LIHC) is the predominant subtype. Doxorubicin (DOX), an anthracycline chemotherapy drug, is extensively employed in the clinical treatment of early-stage and mid-stage liver […]
Nanoparticles-mediated mitochondrial relocation of lipid-lowering drugs shape energy metabolism to conquer acquired immune resistance
Drug Resist Updat. 2025 Nov 4;84:101323. doi: 10.1016/j.drup.2025.101323. Online ahead of print. ABSTRACT CD276, is a fatal recently discovered immune checkpoint proteins of B7 family. Due to the not clearly uncovered signal pathways that involved in the expression of CD276 in tumors, few strategies were discovered to regulate CD276. Here, we newly discovered that abnormal […]
Biological aging phenotypes mediate gut microbiota effects on age-related macular degeneration subtype progression: genetic causality by mendelian randomization and mediation analysis
AMB Express. 2025 Nov 7;15(1):167. doi: 10.1186/s13568-025-01972-9. ABSTRACT The mechanisms driving age-related macular degeneration (AMD) progression into two major but distinct vision-threatening subtypes, geographic atrophy (GA) and choroidal neovascularization (CNV), are unclear. This study identifies causal gut microbiota (GM) taxa involved in AMD and their connections to biological aging phenotypes, including epigenetic clock acceleration, telomere […]
Non-invasive bioelectrical therapy suppresses retinal neovascularization by modulating cellular metabolism and inflammation
Cell Commun Signal. 2025 Nov 6;23(1):479. doi: 10.1186/s12964-025-02451-1. ABSTRACT BACKGROUND: Pathological retinal neovascularization, a major cause of blindness, occurs in conditions such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Microglial activation and chronic neuroinflammation play critical roles in disease progression by promoting vascular permeability and angiogenesis. While anti-VEGF therapies are the current standard […]
From Castro to Quantum Mechanics: Marching Through Tunnels With Reactive Oxygen Species
J Neuroophthalmol. 2025 Oct 16. doi: 10.1097/WNO.0000000000002400. Online ahead of print. ABSTRACT The 2025 Jacobson Lecture revealed a scientific journey that began with the Cuban epidemic of blindness to recent studies of the quantum mechanical underpinnings of Leber’s Hereditary Optic Neuropathy (LHON). A sudden outbreak of bilaterally symmetrical optic neuropathy and peripheral neuropathy in more […]
Lactylated histone H4K8 regulation of MFN2/Wnt signaling integrates glycolytic metabolism and Müller cell activation in the pathogenesis of glaucoma
Neurobiol Dis. 2025 Nov 4:107178. doi: 10.1016/j.nbd.2025.107178. Online ahead of print. ABSTRACT Elevated intraocular pressure (IOP) imposes a substantial glycolytic demand on retinal tissue, driving excessive lactate production to sustain neuronal energy homeostasis. In the present study, we demonstrate that this metabolic stress markedly increases histone H4 lysine 8 lactylation (H4K8la) throughout the glaucomatous retina. […]
Beyond Impaired GABAergic Signaling: Inflammation and Metabolic Dysfunction in Genetic Epilepsy Induced by GABRG2 Mutation
Mol Neurobiol. 2025 Nov 5;63(1):3. doi: 10.1007/s12035-025-05277-7. ABSTRACT Although the mechanisms underlying genetic epilepsies associated with mutations in the γ-aminobutyric acid type A receptor γ2 subunit gene (GABRG2) have been extensively investigated, prior studies primarily focused on the functional alterations of mutant ion channels. Emerging evidence has indicated that neuroinflammation and metabolic disturbances are involved […]
Homocysteine and Diabetic Retinopathy
Exp Eye Res. 2025 Nov 3:110729. doi: 10.1016/j.exer.2025.110729. Online ahead of print. ABSTRACT Diabetic retinopathy (DR), a leading cause of blindness in working-age adults, is a complex neurovascular complication of diabetes mellitus. Beyond chronic hyperglycemia, hyperhomocysteinemia (HHcy) has emerged as a significant modulator of DR progression. This review delineates the multifaceted role of HHcy in […]
Cepharanthine-induced mitophagy through regulation of FBXL4-BNIP3 drives ferroptosis leading to robust anti-lung cancer efficacy
Free Radic Biol Med. 2025 Oct 31:S0891-5849(25)01334-6. doi: 10.1016/j.freeradbiomed.2025.10.302. Online ahead of print. ABSTRACT Cepharanthine (Cep), a natural alkaloid from Stephania (Menispermaceae), exhibits broad-spectrum anti-cancer activity. In the present study, Cep was found to induce ferroptosis and mitophagy, for which the relationship and upstream targets remain unelucidated. Herein, the role of Cep in the induction […]