Preclinical Assessment of Mitochondrial-Targeted ND4 Gene Therapy for Leber Hereditary Optic Neuropathy
Invest Ophthalmol Vis Sci. 2025 Nov 3;66(14):58. doi: 10.1167/iovs.66.14.58. ABSTRACT PURPOSE: The purpose of this study was to establish preclinical safety data to advance mitochondrial targeted AAV-delivered human ND4 (MTSAAV/hND4) for treatment of Leber Hereditary Optic Neuropathy (LHON). METHODS: MTSAAV/hND4 was bilaterally injected into mouse eyes to evaluate potential adverse effects on visual function using […]
Causal Effects Between Retinal Characteristics and Cardiovascular Diseases: Insights from Genetic Correlation, Mendelian Randomization, and Cross-Sectional Study
Glob Heart. 2025 Nov 21;20(1):104. doi: 10.5334/gh.1493. eCollection 2025. ABSTRACT BACKGROUND: Cardiovascular diseases (CVDs) are the leading global cause of mortality and disability, with prevalence increasing due to aging and risk factors like obesity and hypertension. The retina, rich in microvasculature, provides a unique opportunity to investigate microvascular dysfunction linked to CVDs and other systemic […]
Activation of GSDME by all-trans-retinal increases sensitivity to photoreceptor ferroptosis
Int J Biol Sci. 2025 Oct 27;21(15):7029-7042. doi: 10.7150/ijbs.114187. eCollection 2025. ABSTRACT Impaired clearance of all-trans-retinal (atRAL) due to visual cycle dysfunction contributes to photoreceptor atrophy, a key pathological hallmark of Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (AMD). Prior studies have shown that light-induced atRAL accumulation promotes ferroptosis and activates gasdermin […]
Nutraceuticals and neuroprotection for glaucoma-introducing the NP-10 System
Ther Adv Ophthalmol. 2025 Nov 20;17:25158414251393125. doi: 10.1177/25158414251393125. eCollection 2025 Jan-Dec. ABSTRACT Glaucoma, a leading global cause of irreversible blindness, often progresses despite adequate intraocular pressure (IOP) control, highlighting a crucial unmet need for neuroprotective strategies that directly promote retinal ganglion cell survival. In addition, the glaucoma standard of care is often reactive, initiating only […]
In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON
Nat Commun. 2025 Nov 23. doi: 10.1038/s41467-025-66600-3. Online ahead of print. ABSTRACT Leber hereditary optic neuropathy (LHON), a maternally inherited mitochondrial disorder, results from point mutations in mitochondrial DNA (mtDNA), primarily affecting the MT-ND4 gene. To date, no animal model harboring authentic LHON mutations has been available, limiting therapeutic development. However, when we attempted to […]
Acute High Intraocular Pressure Induced by Vitreous Cavity Infusion: an animal model to evaluate corneal endothelial injuries
Exp Eye Res. 2025 Nov 20:110765. doi: 10.1016/j.exer.2025.110765. Online ahead of print. ABSTRACT Elevated intraocular pressure (IOP) is a critical factor in corneal endothelial cells (CECs) injury, yet the precise mechanisms remain poorly understood due to confounding variables in clinical studies. This study developed an acute high IOP model in New Zealand rabbits by vitreous […]
First record of Argulus japonicus infestation on Cyprinus carpio in Hungary, and the first description of Argulus japonicus europaeus subsp. nov. Keve, 2025
Parasit Vectors. 2025 Nov 21;18(1):480. doi: 10.1186/s13071-025-07106-1. ABSTRACT BACKGROUND: Species belonging to the genus Argulus are globally distributed fish parasites. Their veterinary significance primarily lies in their disruptive presence and their role as mechanical vectors. Although Argulus japonicus Thiele, 1900 is a widely distributed representative of this genus that feeds on freshwater fish, only Argulus […]
Amniotic membrane transplantation promotes retinal hole closure in a rabbit model
Sci Rep. 2025 Nov 21;15(1):41253. doi: 10.1038/s41598-025-25162-6. ABSTRACT Amniotic membrane transplantation (AMT) is an effective treatment for refractory macular hole closure, yet the underlying mechanism supporting that effectiveness remains unclear. Here, we investigated the role of retinal regeneration in this process using an in vivo rabbit retinal-hole (RH) model in which AMT was performed on […]
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3
Int J Biol Macromol. 2025 Nov 19:149102. doi: 10.1016/j.ijbiomac.2025.149102. Online ahead of print. ABSTRACT Cataracts seriously affect the vision of patients and can even lead to blindness. RAB3GAP2 is associated with cataracts, but its regulatory effects on cataracts need to be determined. We established a mouse model of cataracts and cell models of cataracts induced […]
IT TAKES TWO TO TANGO: potential novel therapies for autosomal dominant optic atrophy
Front Ophthalmol (Lausanne). 2025 Nov 5;5:1688232. doi: 10.3389/fopht.2025.1688232. eCollection 2025. ABSTRACT Autosomal dominant optic atrophy (ADOA) is among the most prevalent inherited optic neuropathies with hallmark symptoms of bilateral, painless, progressive, and typically permanent vision loss over time. ADOA can affect patients’ quality of life with debilitating visual symptoms, and there is a pressing need […]