Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression
Mycopathologia. 2025 Sep 15;190(5):85. doi: 10.1007/s11046-025-00992-0. ABSTRACT INTRODUCTION: Aspergillus fumigatus poses significant clinical challenges due to its increasing azole resistance. This study investigates the sdh1 gene’s role in regulating azole susceptibility, mitochondrial function, and virulence. MATERIALS AND METHODS: Fungal strains were co-cultured with varying concentrations of succinate dehydrogenase inhibitors (SDHIs). Post-treatment azole minimum inhibitory concentrations […]
Dehydroepiandrosterone Prevents Collagen Loss by Regulating HIF-1α Expression and Mitophagy in Hypoxic Human Scleral Fibroblasts
Am J Pathol. 2025 Sep 12:S0002-9440(25)00342-6. doi: 10.1016/j.ajpath.2025.07.018. Online ahead of print. ABSTRACT Myopia progression and its associated complications, which can lead to vision impairment, primarily result from persistent abnormal elongation of the eye’s axial length. The previous metabonomic analysis of intraocular fluids suggested intraocular hormones may play a role in high myopia pathogenesis. In […]
Next-Gen Neuroprotection in Glaucoma: Synergistic Molecules for Targeted Therapy
J Clin Med. 2025 Aug 30;14(17):6145. doi: 10.3390/jcm14176145. ABSTRACT BACKGROUND: Glaucoma is a progressive optic neuropathy marked by retinal ganglion cells (RGCs), apoptosis, vascular insufficiency, oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation. While intraocular pressure (IOP) reduction remains the primary intervention, many patients continue to lose vision despite adequate pressure control. Emerging neuroprotective agents-citicoline, coenzyme […]
Imbalanced mitochondrial homeostasis in ocular diseases: unique pathogenesis and targeted therapy
Exp Eye Res. 2025 Sep 8:110632. doi: 10.1016/j.exer.2025.110632. Online ahead of print. ABSTRACT Mitochondria play a crucial role in energy production and are intimately associated with ocular function. Mitochondrial dysfunction can trigger oxidative stress and inflammation, adversely affecting key ocular structures such as the lacrimal gland, lens, retina, and trabecular meshwork. This dysfunction may compromise […]
Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission
Proc Natl Acad Sci U S A. 2025 Sep 16;122(37):e2426578122. doi: 10.1073/pnas.2426578122. Epub 2025 Sep 9. ABSTRACT Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an […]
MetabOCT: a clinical trial looking for a metabolomic signature predicting the onset of Leber’s hereditary optic neuropathy in healthy MtDNA mutations carriers
Metabolomics. 2025 Sep 9;21(5):134. doi: 10.1007/s11306-025-02328-x. ABSTRACT INTRODUCTION: The definition of Leber’s hereditary optic neuropathy (LHON) does not take into account a preclinical phase during which the thickness of retinal nerve fiber layer (RNFL) is increased, prior to optic nerve atrophy, reducing the chances of visual recovery. OBJECTIVES: Search for a metabolomic signature characterizing this […]
Case Report: Abnormal pupils caused by the mitochondrial MT-TL1 gene m.3243A>G mutation
Front Pediatr. 2025 Aug 21;13:1573886. doi: 10.3389/fped.2025.1573886. eCollection 2025. ABSTRACT BACKGROUND: The m.3243A>G mutation in the MT-TL1 gene is the most common mtDNA mutation. The mutation can lead to a spectrum of conditions, including diabetes, hearing loss, heart and muscle involvement, encephalopathy and epilepsy, gastrointestinal problems, and vision impairment, often occurring concurrently-collectively referred to as […]
The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins
Front Cell Neurosci. 2025 Aug 22;19:1634262. doi: 10.3389/fncel.2025.1634262. eCollection 2025. ABSTRACT BACKGROUND: Imeglimin (Ime), the first in a novel class of antidiabetic agents, has potential therapeutic effects on diabetic peripheral neuropathy (DPN). This study aimed to evaluate and compare the effects on cellular metabolic function and reactive oxygen species (ROS) levels in high glucose-treated mouse […]
Light-emitting diode-derived blue light overexposure accelerates corneal endothelial cell aging by inducing abnormal ROS accumulation
J Photochem Photobiol B. 2025 Sep 1;272:113252. doi: 10.1016/j.jphotobiol.2025.113252. Online ahead of print. ABSTRACT Blue light, defined as short-wavelength visible light ranging from 400 to 500 nm, is recognized for its high energy within the visible light spectrum. The prevalent use of light-emitting diodes (LEDs) has significantly increased exposure to blue light. Corneal endothelial cells […]
A novel protein encoded by hsa_circ_0068626 contributes to age-related cataract via the p62/Keap1/Nrf2 signaling pathway-mediated ferroptosis
Exp Eye Res. 2025 Sep 3:110601. doi: 10.1016/j.exer.2025.110601. Online ahead of print. ABSTRACT This study investigates whether circular RNAs (circRNAs) modulate ferroptosis in lens epithelial cells (LECs) during age-related cataract (ARC) pathogenesis via novel encoded proteins. Initial circRNA-sequencing identified hsa_circ_0068626 (circTFRC) as significantly upregulated in ARC, predominantly localized to the cytoplasm through nuclear-cytoplasmic fractionation and […]