Fat oxidation rates and cardiorespiratory responses during exercise in different subject populations with post-acute sequelae of SARS-CoV-2 infection: a comparison with normative percentile values
Front Physiol. 2023 Dec 8;14:1310319. doi: 10.3389/fphys.2023.1310319. eCollection 2023. ABSTRACT Introduction: Post-acute sequelae of SARS-CoV-2 infection (PASC) presents a spectrum of symptoms following acute COVID-19, with exercise intolerance being a prevalent manifestation likely linked to disrupted oxygen metabolism and mitochondrial function. This study aims to assess maximal fat oxidation (MFO) and exercise intensity at MFO […]
Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism
J Extracell Vesicles. 2024 Jan;13(1):e12401. doi: 10.1002/jev2.12401. ABSTRACT Retinal degeneration (RD), a group of diseases leading to irreversible vision loss, is characterised by retinal pigment epithelium (RPE) or retinal neuron damage and loss. With fewer risks of immune rejection and tumorigenesis, stem cell-secreted extracellular vesicles (EVs) offer a new cell-free therapeutic paradigm for RD, which […]
Vitamin B3 Supplementation for Optic Neuropathies: A Comprehensive Review
J Ocul Pharmacol Ther. 2023 Dec 27. doi: 10.1089/jop.2023.0125. Online ahead of print. ABSTRACT Optic neuropathies, such as glaucoma, are some of the leading causes of irreversible blindness worldwide. There has been a lot of research for potential therapies that could attenuate and even reduce the impact of the pathological pathways that lead to the […]
Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice
J Alzheimers Dis. 2023 Dec 18. doi: 10.3233/JAD-231102. Online ahead of print. ABSTRACT BACKGROUND: Increasing evidence has highlighted retinal impairments in neurodegenerative diseases. Dominant mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS), and the accumulation of TDP-43 in the cytoplasm is a pathological hallmark of ALS, frontotemporal dementia (FTD), and many […]
Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy
Ocul Surf. 2023 Dec 21:S1542-0124(23)00157-X. doi: 10.1016/j.jtos.2023.12.006. Online ahead of print. ABSTRACT PURPOSE: Diabetes mellitus (DM) is a leading risk factor for corneal neuropathy and dry eye disease (DED). Another common consequence of DM is diabetic peripheral polyneuropathy (DPN). Both complications affect around 50 % of the DM patients but the relationship between DM, DED […]
20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels
Neuroreport. 2023 Dec 22. doi: 10.1097/WNR.0000000000001990. Online ahead of print. ABSTRACT CONTEXT: Sevoflurane is an inhalational anesthetic widely used in pediatric surgery. However, animal studies have shown that multiple sevoflurane exposures during the neonatal period led to ototoxicity. 20(S)-Ginsenoside Rh1, a ginsenoside extract, protects against cisplatin-induced ototoxicity by scavenging free radicals. OBJECTIVE: This study aimed […]
DNAJC30 Gene Variants Are a Frequent Cause of a Rare Disease: Leber Hereditary Optic Neuropathy in Polish Patients
Int J Mol Sci. 2023 Dec 15;24(24):17496. doi: 10.3390/ijms242417496. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare disorder causing a sudden painless loss of visual acuity in one or both eyes, affecting young males in their second to third decade of life. The molecular background of the LHON is up to 90%, genetically defined […]
RNA-Sequencing Analysis Reveals the Role of Mitochondrial Energy Metabolism Alterations and Immune Cell Activation in Form-Deprivation and Lens-Induced Myopia in Mice
Genes (Basel). 2023 Nov 30;14(12):2163. doi: 10.3390/genes14122163. ABSTRACT Myopia is a substantial global public health concern primarily linked to the elongation of the axial length of the eyeball. While numerous animal models have been employed to investigate myopia, the specific contributions of genetic factors and the intricate signaling pathways involved remain incompletely understood. In this […]
Benzalkonium chloride greatly deteriorates the biological activities of human corneal stroma fibroblasts in a concentration-dependent manner
Graefes Arch Clin Exp Ophthalmol. 2023 Dec 22. doi: 10.1007/s00417-023-06325-5. Online ahead of print. ABSTRACT BACKGROUND: Corneal tissues indirectly obtain nutritional needs and oxygen to maintain their homeostasis, and therefore, benzalkonium chloride (BAC) containing ocular instillations for medical therapy may, in turn, induce toxic effects more than expected in corneal tissues, especially the inside stroma […]
Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis
Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec 22. doi: 10.1007/s00210-023-02897-5. Online ahead of print. ABSTRACT Septic cardiomyopathy (SCM) is manifested by impairment of cardiac contractile function with myocardial mitochondrial dysregulation. Natural product, songorine (SGR), a diterpenoid alkaloid derived from the lateral root of Aconitum carmichaeli, has been reported for the treatment of heart failure. Here, the […]