Long-term exposure to PM(2.5) leads to mitochondrial damage and differential expression of associated circRNA in rat hepatocytes
Sci Rep. 2024 May 24;14(1):11870. doi: 10.1038/s41598-024-62748-y. ABSTRACT Fine particulate matter (PM2.5) is one of the four major causes of mortality globally. The objective of this study was to investigate the mechanism underlying liver injury following exposure to PM2.5 and the involvement of circRNA in its regulation. A PM2.5 respiratory tract exposure model was established […]
Ophthalmomyiasis Case Caused by Two Blow Fly (Diptera: Calliphoridae) Species in North America
ScientificWorldJournal. 2024 May 14;2024:2209301. doi: 10.1155/2024/2209301. eCollection 2024. ABSTRACT Ophthalmomyiasis is the result of fly larvae feeding on the tissues of the eye. Commonly associated with poor hygiene and open wounds, this condition is rare and often stigmatized. Treatment can be straightforward, and full recovery is common. Identifying the species responsible for ophthalmomyiasis is important […]
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Cell Biosci. 2024 May 21;14(1):64. doi: 10.1186/s13578-024-01243-3. ABSTRACT BACKGROUND: Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigment epithelium (RPE). MicroRNAs (miRs) are implicated in RP pathogenesis, and downregulating miR-181a/b has shown therapeutic benefit in RP […]
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Acta Neuropathol Commun. 2024 May 21;12(1):79. doi: 10.1186/s40478-024-01782-3. ABSTRACT Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death. The retina is often affected in common neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Studies have demonstrated that the retina in patients with […]
Human Conjunctival Transcriptome in Acanthamoeba Keratitis: An Exploratory Study
Cornea. 2024 May 21. doi: 10.1097/ICO.0000000000003545. Online ahead of print. ABSTRACT PURPOSE: The purpose of this study was to identify conjunctival transcriptome differences in patients with Acanthamoeba keratitis compared with keratitis with no known associated pathogen. METHODS: The host conjunctival transcriptome of 9 patients with Acanthamoeba keratitis (AK) is compared with the host conjunctival transcriptome […]
Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression
Discov Oncol. 2024 May 21;15(1):178. doi: 10.1007/s12672-024-01045-6. ABSTRACT OBJECTIVE: Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional Chinese medicine to intervene and treat melanoma, we turned our attention to celastrol. […]
l-Serine Protects Murine Retinal Ganglion Cells from Oxidative Stress via Modulation of Mitochondrial Dysfunction
Curr Eye Res. 2024 May 21:1-9. doi: 10.1080/02713683.2024.2355661. Online ahead of print. ABSTRACT PURPOSE: This study aimed to investigate the effects of l-serine on mitochondrial dysfunction in retinal ganglion cells after exposure to H2O2-induced oxidative stress. METHODS: Retinal ganglion cells obtained from C57BL6 mice (postnatal days 1-4) were purified and cultured. A cell viability assay […]
Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting
ACS Appl Mater Interfaces. 2024 May 20. doi: 10.1021/acsami.4c01382. Online ahead of print. ABSTRACT Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and the regulation of TPP linkage modes […]
Impaired mitochondrial morphological plasticity and failure of mitophagy associated with the G11778A mutation of LHON
Biochem Biophys Res Commun. 2024 May 14;721:150119. doi: 10.1016/j.bbrc.2024.150119. Online ahead of print. ABSTRACT Mitochondrial dynamics were examined in human dermal fibroblasts biopsied from a confirmed Leber’s Hereditary Optic Neuropathy (LHON) patient with a homoplasmic G11778A mutation of the mitochondrial genome. Expression of the G11778A mutation did not impart any discernible difference in mitochondrial network […]
Histopathological findings of anterior lens capsule in pediatric cataract
Indian J Ophthalmol. 2024 May 20. doi: 10.4103/IJO.IJO_2957_23. Online ahead of print. ABSTRACT PURPOSE: To investigate the histopathological findings of the anterior lens capsule in pediatric patients who had surgery for cataracts. METHODS: This study is a prospective interventional study. Anterior capsule tissue samples that were obtained by the anterior capsulotomy method during phacoemulsification surgery […]