Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration
Cell Death Dis. 2024 Oct 19;15(10):763. doi: 10.1038/s41419-024-07150-2. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models of AMD have revealed the significance of impaired lipid metabolism and anti-oxidative […]
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Angiogenesis. 2024 Oct 19. doi: 10.1007/s10456-024-09952-6. Online ahead of print. NO ABSTRACT PMID:39425886 | DOI:10.1007/s10456-024-09952-6
Clinical and genetic landscape of optic atrophy in 826 families: insights from 50 nuclear genes
Brain. 2024 Oct 18:awae324. doi: 10.1093/brain/awae324. Online ahead of print. ABSTRACT Hereditary optic neuropathies (HON) are a group of diseases due to genetic defects either in mitochondria or in nuclear genomes. The increasing availability of genetic testing has expanded a broader genetic and phenotypic spectrum of HON than previously recognized. To provide systematic insight into […]
Meta-analysis of treatment outcomes for patients with m.11778G>A MT-ND4 Leber Hereditary Optic Neuropathy
Surv Ophthalmol. 2024 Oct 15:S0039-6257(24)00130-9. doi: 10.1016/j.survophthal.2024.10.002. Online ahead of print. ABSTRACT Our aim was to assess the visual outcomes of patients with Leber hereditary optic neuropathy (LHON) harboring the m.11778G>A MT-ND4 mutation who had no treatment (natural history) or received idebenone or lenadogene nolparvovec. Efficacy outcomes included clinically relevant recovery (CRR) from nadir and […]
TiO2-Nanoparticle-Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism
Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):24. doi: 10.1167/iovs.65.12.24. ABSTRACT PURPOSE: To explore the application and potential ferroptosis mechanisms of sonodynamic therapy (SDT) using titanium dioxide nanoparticles (TiO2-NPs) as sonosensitizers for the prevention of posterior capsule opacification (PCO). METHODS: We fabricated TiO2-NP-coated intraocular lenses (TiO2-IOLs) using the spin-coating method, followed by ultrasound activation of the […]
The Role of Nicotinamide Riboside in the Preservation of Retinal Ganglion Cells Using An In Vitro Glutamate-Induced Excitotoxicity Model
Exp Eye Res. 2024 Oct 14:110126. doi: 10.1016/j.exer.2024.110126. Online ahead of print. ABSTRACT Delaying or preventing the loss of retinal ganglion cells (RGCs) in glaucoma is needed for vision preservation. Glutamate-mediated neurotoxicity arises from the excessive stimulation of N-methyl-D-aspartate membrane receptors by glutamate. This overstimulation, occurring specifically in RGCs, triggers a progressive deterioration of the […]
Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy
Autophagy. 2024 Oct 16:1-17. doi: 10.1080/15548627.2024.2409613. Online ahead of print. ABSTRACT Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage. Moreover, […]
Multifocal vitelliform lesions associated with mitochondrial retinopathy
Am J Ophthalmol Case Rep. 2024 Oct 2;36:102181. doi: 10.1016/j.ajoc.2024.102181. eCollection 2024 Dec. ABSTRACT PURPOSE: To report a case of multifocal vitelliform lesions in a patient affected by metabolic encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) with the m.3243A>G variant. OBSERVATIONS: A 37-year-old woman affected by MELAS was referred to our center for progressive vision […]
Hypoxia-mediated rescue of retinal ganglion cells deficient in mitochondrial complex I is independent of the hypoxia-inducible factor pathway
Sci Rep. 2024 Oct 15;14(1):24114. doi: 10.1038/s41598-024-75916-x. ABSTRACT Continuous exposure to environmental hypoxia (11% O2) has been shown to markedly slow the progressive degeneration of retinal ganglion cells (RGCs) in a mouse model of mitochondrial optic neuropathy with RGC-specific deletion of the key mitochondrial complex I accessory subunit ndufs4. As a first step toward identifying […]
Exploring the Potential of Synthetic Cannabinoids: Modulation of Biological Activity of Normal and Cancerous Human Colon Epithelial Cells
Cells. 2024 Sep 26;13(19):1616. doi: 10.3390/cells13191616. ABSTRACT Colorectal cancer (CRC) is a global problem. Oncology currently practices conventional methods of treating this carcinoma, including surgery, chemotherapy, and radiotherapy. Unfortunately, their efficacy is low; hence, the exploration of new therapies is critical. Recently, many efforts have focused on developing safe and effective anticancer compounds. Some of […]