Category: Ophthalmology AND mitochondrial

High-Glucose-Induced Metabolic and Redox Alterations Are Distinctly Modulated by Various Antidiabetic Agents and Interventions Against FABP5/7, MITF and ANGPTL4 in Melanoma A375 Cells

Int J Mol Sci. 2025 Jan 24;26(3):1014. doi: 10.3390/ijms26031014. ABSTRACT Hyperglycemia-induced effects on cellular metabolic properties and reactive oxygen species (ROS) generation play pivotal roles in the pathogenesis of malignant melanoma (MM). This study assessed how metabolic states, ROS production, and related gene expression are modulated by antidiabetic agents. The anti-diabetic agents metformin (Met) and […]

A Dynamic Deferoxamine Polymer with Exceptional Performance in Mitochondrial Iron Depletion and Cytosolic Protein Delivery

Small. 2025 Feb 13:e2412093. doi: 10.1002/smll.202412093. Online ahead of print. ABSTRACT Deferoxamine (DFO) is an FDA-approved naturally occurring iron chelator commonly used to treat transfusion-induced iron overload. The abundant and flexible hydroxamic acid groups in DFO enable exceptional iron binding capacity and high protein binding via hydrogen bonding interactions. However, the applications of DFO to […]

The Potential Roles of IL-1β, IL-6, and RIPK3 in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Diagnostics (Basel). 2025 Jan 26;15(3):290. doi: 10.3390/diagnostics15030290. ABSTRACT Background/Objectives: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are rare but severe skin conditions, often triggered by medications, that can be life-threatening. These conditions frequently affect the eyes, causing ocular surface disease, which can result in visual impairment or blindness. Although the exact mechanisms behind SJS/TEN remain […]

Disrupted Mitochondrial Dynamics Impair Corneal Epithelial Healing in Neurotrophic Keratopathy

Int J Mol Sci. 2025 Feb 3;26(3):1290. doi: 10.3390/ijms26031290. ABSTRACT Neurotrophic keratopathy (NK) is a degenerative corneal disease characterized by impaired corneal sensitivity and epithelial repair that is often linked to sensory nerve dysfunction. To establish a clinically relevant model and explore the mechanisms underlying NK pathogenesis, we developed a novel mouse model through partial […]

The Role of Visual Electrophysiology in Systemic Hereditary Syndromes

Int J Mol Sci. 2025 Jan 23;26(3):957. doi: 10.3390/ijms26030957. ABSTRACT Visual electrophysiology is a valuable tool for evaluating the visual system in various systemic syndromes. This review highlights its clinical application in a selection of syndromes associated with hearing loss, mitochondrial dysfunction, obesity, and other multisystem disorders. Techniques such as full-field electroretinography (ffERG), multifocal electroretinography […]

Endoplasmic Reticulum-Mitochondria Crosstalk in Fuchs Endothelial Corneal Dystrophy: Current Status and Future Prospects

Int J Mol Sci. 2025 Jan 22;26(3):894. doi: 10.3390/ijms26030894. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is a progressive and debilitating disorder of the corneal endothelium (CE) that affects approximately 4% of individuals over the age of 40. Despite the burden of the disease, the pathogenesis of FECD remains poorly understood, and treatment options are limited, […]

Enhancing the Photocatalytic Efficacy of g-C3N4 Through Irradiation Modification and Composite Construction with Ti3C2 for Photodynamic Therapy

Molecules. 2025 Jan 22;30(3):487. doi: 10.3390/molecules30030487. ABSTRACT Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (Ti3C2, TC)/graphitic carbon nitride (g-C3N4, CN) nanocomposite through a synergistic approach combining electron beam irradiation and 2D/2D composite formation. […]

Metabolic dysregulation in glaucoma

Clin Exp Optom. 2025 Feb 12:1-7. doi: 10.1080/08164622.2025.2463502. Online ahead of print. ABSTRACT Glaucoma is a multifactorial neurodegenerative disorder characterised by the progressive loss of retinal ganglion cells, ultimately leading to irreversible blindness worldwide. Recent research highlights metabolic dysregulation as a crucial factor in the pathophysiology of glaucoma. This review examines the intricate relationship between […]

Mitochondrial Dysfunction During TGF-beta1-Induced Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

Curr Eye Res. 2025 Feb 12:1-9. doi: 10.1080/02713683.2025.2464783. Online ahead of print. ABSTRACT PURPOSE: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells contributes to the epiretinal membrane development in proliferative vitreoretinopathy (PVR). This study aimed at investigating changes in mitochondrial function during EMT in PVR. METHODS: Transmission electron microscopy (TEM) was utilized to examine […]