The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium
Free Radic Biol Med. 2024 Nov 2:S0891-5849(24)01015-3. doi: 10.1016/j.freeradbiomed.2024.10.307. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD), the leading cause of central vision loss in the elderly, involves death of the retinal pigment epithelium (RPE) and light-sensing photoreceptors. This multifactorial disease includes contributions from both genetic and environmental risk factors. The current study examined […]
SIRT3 mitigates high glucose-induced damage in retinal microvascular endothelial cells via OPA1-mediated mitochondrial dynamics
Exp Cell Res. 2024 Nov 2:114320. doi: 10.1016/j.yexcr.2024.114320. Online ahead of print. ABSTRACT Oxidative stress in endothelial cells is pivotal in diabetic retinopathy (DR), with mitochondrial homeostasis being crucial to mitigate this stress. This study explored the roles of mitochondrial sirtuins (SIRTs) in high glucose (HG)-induced oxidative stress, related endothelial impairment, and mitochondrial homeostasis damage […]
Integrative multiomic analysis unveils the molecular nexus of mitochondrial dysfunction in the pathogenesis of age-related macular degeneration
Exp Eye Res. 2024 Oct 26:110141. doi: 10.1016/j.exer.2024.110141. Online ahead of print. ABSTRACT Mitochondrial dysfunction is linked to age-related macular degeneration (AMD), but its mechanisms and related molecular networks remain unclear. We explored the association between mitochondrial-related genes and AMD by integrating multiomic data. We acquired summary-level data on mitochondrial-related protein abundance, gene expression, and […]
Association of optic disc drusen and small scleral canals – A systematic review and meta-analysis
Eye (Lond). 2024 Nov 2. doi: 10.1038/s41433-024-03451-0. Online ahead of print. ABSTRACT The pathophysiology of optic disc drusen (ODD) has long been discussed. According to one leading theory, they develop from calcified mitochondria extruded from axons compressed by an unusually small scleral canal. To examine this hypothesis, we conducted a systematic review and meta-analysis evaluating […]
AARS2-Related Disorder
2024 Oct 31. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: AARS2-related disorder includes two distinct phenotypes, infantile-onset cardiomyopathy and neurodegeneration with or without leukoencephalopathy. AARS2-related infantile-onset cardiomyopathy is characterized by hypertrophic cardiomyopathy, hypotonia, skeletal myopathy, and […]
Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth
Cell Metab. 2024 Oct 24:S1550-4131(24)00398-X. doi: 10.1016/j.cmet.2024.10.002. Online ahead of print. ABSTRACT Fructose is associated with colorectal cancer tumorigenesis and metastasis through ketohexokinase-mediated metabolism in the colorectal epithelium, yet its role in the tumor immune microenvironment remains largely unknown. Here, we show that a modest amount of fructose, without affecting obesity and associated complications, promotes […]
Corrigendum: Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes
Front Immunol. 2024 Oct 14;15:1500666. doi: 10.3389/fimmu.2024.1500666. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fimmu.2024.1411957.]. PMID:39469710 | PMC:PMC11513589 | DOI:10.3389/fimmu.2024.1500666
Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress
FASEB J. 2024 Oct;38(20):e70135. doi: 10.1096/fj.202401160RR. ABSTRACT The intake of high dietary fat has been correlated with the progression of age-related macular degeneration (AMD), affecting the function of the retinal pigment epithelium through oxidative stress. A high-fat diet (HFD) can lead to lipid metabolism disorders, excessive production of circulating free fatty acids, and systemic inflammation […]
Ion Channel Piezo1 Induces Ferroptosis of Trabecular Meshwork Cells: A Novel Observation in the Pathogenesis in Primary Open Angle Glaucoma
Am J Physiol Cell Physiol. 2024 Oct 28. doi: 10.1152/ajpcell.00173.2024. Online ahead of print. ABSTRACT PURPOSE: This study aims to elucidate the role of Piezo1, a mechanosensitive molecule, in trabecular meshwork cells (TMCs) in the context of Primary Open Angle Glaucoma (POAG), a leading cause of irreversible visual impairment. Dysfunction of the trabecular meshwork (TM) […]
Prognostic Prediction and Immune Microenvironment Characterization in Uveal Melanoma: A Novel Mitochondrial Metabolism-Related Gene Signature
ACS Omega. 2024 Oct 10;9(42):43034-43045. doi: 10.1021/acsomega.4c06294. eCollection 2024 Oct 22. ABSTRACT Uveal Melanoma (UM), a highly aggressive and metastatic intraocular cancer with a strong propensity for liver metastasis, presents limited therapeutic alternatives and unfavorable survival outcomes. Despite its low incidence, the underlying mechanisms of UM pathogenesis and the precise role of mitochondrial metabolism in […]