Structure-Function Correlation in Cobalt-Induced Brain Toxicity
Cells. 2024 Oct 24;13(21):1765. doi: 10.3390/cells13211765. ABSTRACT Cobalt toxicity is difficult to detect and therefore often underdiagnosed. The aim of this study was to explore the pathophysiology of cobalt-induced oxidative stress in the brain and its impact on structure and function. Thirty-five wild-type C57B16 mice received intraperitoneal cobalt chloride injections: a single high dose with […]
Prominin-1 Knockdown Causes RPE Degeneration in a Mouse Model
Cells. 2024 Oct 24;13(21):1761. doi: 10.3390/cells13211761. ABSTRACT There are currently no effective treatments for retinal pigment epithelial (RPE) cell loss in atrophic AMD (aAMD). However, our research on Prominin-1 (Prom1), a known structural protein in photoreceptors (PRs), has revealed its distinct role in RPE and offers promising insights. While pathogenic Prom1 mutations have been linked […]
Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):10. doi: 10.1167/iovs.65.13.10. ABSTRACT PURPOSE: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms […]
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):12. doi: 10.1167/iovs.65.13.12. ABSTRACT PURPOSE: Aging alters the function of the lacrimal gland and disrupts the balance of the microenvironment on the ocular surface, eventually leading to aqueous-tear-deficient dry eye. Mitophagy has been reported to play an important role in aging, but the underlying mechanism remains unclear. METHODS: The […]
The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia
Sci Rep. 2024 Nov 5;14(1):26819. doi: 10.1038/s41598-024-77823-7. ABSTRACT Sperm motility is a crucial factor in male fertility. Photobiomodulation (PBM) has been reported to increase sperm motility, but a consistent approach suitable for identifying standardizable protocols is lacking. We collected asthenozoospermic (n = 70) and normozoospermic (n = 20) semen. The asthenozoospermic samples were irradiated with […]
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen
Aging Dis. 2024 Oct 9. doi: 10.14336/AD.2024.0459. Online ahead of print. ABSTRACT Soft tissue ectopic calcification is due to abnormal accumulation of calcium and phosphate outside the bone. It is the result of the failure of a complex, active, and highly regulated process – much of which is still not well understood. Some of our […]
Cigarette smoke extract induces ferroptosis in human retinal pigment epithelial cells
Heliyon. 2024 Sep 24;10(20):e38151. doi: 10.1016/j.heliyon.2024.e38151. eCollection 2024 Oct 30. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a common blindness diseases. Retinal pigment epithelium (RPE) dysfunction due to smoking is an essential environmental factor in the pathogenesis of AMD. Ferroptosis is a novel type of iron-dependent programmed cell death (PCD). However, the relationship between cigarette […]
N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis
Mol Med. 2024 Nov 4;30(1):196. doi: 10.1186/s10020-024-00965-x. ABSTRACT N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expression profile (mRNA), impaired mitochondrial metabolism (mtRNA), and translational suppression (rRNA) of tumor […]
Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis
BMC Ophthalmol. 2024 Nov 4;24(1):479. doi: 10.1186/s12886-024-03746-6. ABSTRACT BACKGROUND: It is widely accepted that glaucoma-induced oxidative stress expedites cataracts’ process. Therefore, we examined the effects of apelin-13 against oxidative stress-induced damage in human lens epithelial cells (HLECs) and investigated the potential pathogenic mechanism of acute primary angle-closure glaucoma. METHODS: This experiment included five groups: control, […]
Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):3. doi: 10.1167/iovs.65.13.3. ABSTRACT PURPOSE: Conjunctival melanoma (CJM) is a rare malignant ocular surface tumor, which often leads to local recurrences and metastases. In murine models of subcutaneous tumors, treatment with a novel virus-like drug conjugate (VDC; Bel-sar) showed a dual mechanism of action with direct tumor cell killing […]