JP4-039, a Mitochondria-Targeted Nitroxide, Mitigates the Effect of Apoptosis and Inflammatory Cell Migration in the Irradiated Mouse Retina
Int J Mol Sci. 2024 Jun 13;25(12):6515. doi: 10.3390/ijms25126515. ABSTRACT We hypothesize that the injection of JP4-039, a mitochondria-targeted nitroxide, prior to irradiation of the mouse retina may decrease apoptosis and reduce neutrophil and macrophage migration into the retina. In our study, we aimed to examine the effects of JP4-039 in the mouse retina using […]
Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress
Antioxidants (Basel). 2024 Jun 19;13(6):743. doi: 10.3390/antiox13060743. ABSTRACT Oxidative stress is a key factor causing mitochondrial dysfunction and retinal ganglion cell (RGC) death in glaucomatous neurodegeneration. The cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway is involved in mitochondrial protection, promoting RGC survival. Soluble adenylyl cyclase (sAC) is a key regulator of the cyclic […]
The Molecular Mechanisms of Cuproptosis and Small-Molecule Drug Design in Diabetes Mellitus
Molecules. 2024 Jun 15;29(12):2852. doi: 10.3390/molecules29122852. ABSTRACT In the field of human health research, the homeostasis of copper (Cu) is receiving increased attention due to its connection to pathological conditions, including diabetes mellitus (DM). Recent studies have demonstrated that proteins associated with Cu homeostasis, such as ATOX1, FDX1, ATP7A, ATPB, SLC31A1, p53, and UPS, also […]
Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue
Proteomics Clin Appl. 2024 Jun 24:e202400018. doi: 10.1002/prca.202400018. Online ahead of print. ABSTRACT PURPOSE: Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of chronic kidney disease and end-stage renal disease. One potential mechanism underlying cellular dysfunction contributing to kidney disease is aberrant protein post-translational modifications. Lysine acetylation is […]
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA plus syndrome
JCI Insight. 2024 Jun 25:e180582. doi: 10.1172/jci.insight.180582. Online ahead of print. ABSTRACT Autosomal dominant optic atrophy plus (ADOA+) is characterized by primary optic nerve atrophy accompanied by a spectrum of degenerative neurological symptoms. Despite ongoing research, no effective treatments are currently available for this condition. Our study provided evidence for the pathogenicity of an unreported […]
TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma
bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.597951. doi: 10.1101/2024.06.07.597951. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to injury. Tlr4 is highly expressed in ocular tissues and is known to modulate inflammatory processes in both anterior and posterior segment tissues. […]
Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy
Folia Histochem Cytobiol. 2024 Jun 24. doi: 10.5603/fhc.98875. Online ahead of print. ABSTRACT INTRODUCTION: Diabetic cataract (DC) is a common ocular complication of diabetes. Mitofusin 2 (MFN2), a mitochondrial fusion protein, is involved in the pathogenesis of cataract and diabetic complications. However, its role and molecular mechanisms in DC remain unclear. MATERIALS AND METHODS: DC […]
Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Inflammation. 2024 Jun 23. doi: 10.1007/s10753-024-02076-5. Online ahead of print. ABSTRACT Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue damage. Nevertheless, precise targeted and efficient therapies are limited. Thus, studies into novel therapeutic targets for the management of autoimmune diseases are urgently needed. Radical […]
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
BMC Ophthalmol. 2024 Jun 21;24(1):268. doi: 10.1186/s12886-024-03524-4. ABSTRACT BACKGROUND: Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelial function remains unclear. This study aimed to determine the effect and possible mechanism of SD on […]
Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Cell Commun Signal. 2024 Jun 21;22(1):343. doi: 10.1186/s12964-024-01712-9. ABSTRACT Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phosphorylation. In our study, we examined the impact of POLRMT on angiogenesis and found that its silencing or knockout (KO) […]