Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
bioRxiv [Preprint]. 2024 Sep 12:2024.09.09.612106. doi: 10.1101/2024.09.09.612106. ABSTRACT Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain and throughout the body, causing seizures and neurodegeneration in infancy. The mechanistic underpinnings of such neuropathology remains unclear. Here, we characterized the molecular mechanisms by which neuronal […]
Effects of 5G radiofrequency electromagnetic radiation on indicators of vitality and DNA integrity of in vitro exposed boar semen
Theriogenology. 2024 Sep 25;230:243-249. doi: 10.1016/j.theriogenology.2024.09.025. Online ahead of print. ABSTRACT The effects of radiofrequency electromagnetic radiation (RF-EMR) on semen quality have been in the spotlight in recent years, though research results to date have been contradictory. The effects of RF-EMR amongst others depend upon frequency, and there is currently no literature concerning the influence […]
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
J Neuroinflammation. 2024 Sep 28;21(1):245. doi: 10.1186/s12974-024-03214-4. ABSTRACT Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease. Microglia activation is accompanied by the formation and chronic expression of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. The […]
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca2+ homeostasis
Phytomedicine. 2024 Sep 22;135:156088. doi: 10.1016/j.phymed.2024.156088. Online ahead of print. ABSTRACT BACKGROUND: Melatonin is an antioxidant that also has anti-inflammatory effects. It has been reported to delay the progression of age-related macular degeneration (AMD), however, the mechanism has not been fully recognized. PURPOSE: The aim of the present study was to investigate the effects of […]
Clustered ARPE-19 cells distinct in mitochondrial membrane potential may play a pivotal role in cell differentiation
Sci Rep. 2024 Sep 27;14(1):22391. doi: 10.1038/s41598-024-73145-w. ABSTRACT Age-related macular degeneration (AMD) is associated with the dysfunction and degeneration of retinal pigment epithelium (RPE) cells. Here, we examined how the formation and expansions of cell clusters are regulated by the differentiation of the RPE cells. In this study, ARPE-19 cells were cultivated in standard or […]
Crocin Protects the 661W Murine Photoreceptor Cell Line against the Toxic Effects of All-Trans-Retinal
Int J Mol Sci. 2024 Sep 20;25(18):10124. doi: 10.3390/ijms251810124. ABSTRACT Age-related macular degeneration (AMD) is a common disease contributing to vision loss in the elderly. All-trans-retinal (atRAL) is a retinoid in the retina, and its abnormal accumulation exhibits toxicity to the retina and promotes oxidative stress-induced photoreceptor degeneration, which plays a crucial role in AMD […]
Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats
Biomolecules. 2024 Aug 23;14(9):1047. doi: 10.3390/biom14091047. ABSTRACT Rotenone is a mitochondrial complex I inhibitor that causes retinal degeneration. A study of a rat model of rotenone-induced retinal degeneration suggested that this model is caused by indirect postsynaptic N-methyl-D-aspartate (NMDA) stimulation triggered by oxidative stress-mediated presynaptic intracellular calcium signaling. To elucidate the mechanisms by which rotenone […]
Severe Optic Neuropathy Induced by Very Prolonged Tedizolid as Suppressive Therapy: Description of a Case Report and Implication for Better Assessment
Open Forum Infect Dis. 2024 Sep 24;11(9):ofae517. doi: 10.1093/ofid/ofae517. eCollection 2024 Sep. ABSTRACT The long-term tolerability of linezolid is low because of mitochondrial toxicity, whereas tedizolid may represent a better option for suppressive therapy. We report a first presumed case of tedizolid-associated optic neuropathy after a very prolonged (18-month) intake and believe that screening for […]
Current Insights on Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and their significance in the pathophysiology of ocular disorders
Exp Eye Res. 2024 Sep 24:110110. doi: 10.1016/j.exer.2024.110110. Online ahead of print. ABSTRACT The intricate interaction network necessary for essential physiological functions underscores the interdependence among eukaryotic cells. Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs), specialized junctions between mitochondria and the ER, were recently discovered. These junctions participate in various cellular processes, including calcium level regulation, lipid […]
ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1alpha
Invest Ophthalmol Vis Sci. 2024 Sep 3;65(11):39. doi: 10.1167/iovs.65.11.39. ABSTRACT PURPOSE: Retinal detachment (RD) leads to photoreceptor (PR) hypoxia due to separation from the retinal pigment epithelium (RPE). Hypoxia stabilizes retinal hypoxia-inducible factor 1-alpha (HIF1α), crucial for PR survival during RD. This study explores the regulatory role of HIF1α in PR cell survival pathways during […]