Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure
Am J Physiol Heart Circ Physiol. 2024 Dec 1;327(6):H1327-H1342. doi: 10.1152/ajpheart.00539.2024. Epub 2024 Oct 25. ABSTRACT Diabetes mellitus (DM) is characterized by chronic hyperglycemia, and despite intensive glycemic control, the risk of heart failure in patients with diabetes remains high. Diabetes-induced heart failure (DHF) presents a unique metabolic challenge, driven by significant alterations in cardiac […]
Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity
Liver Int. 2024 Nov 15. doi: 10.1111/liv.16167. Online ahead of print. ABSTRACT BACKGROUND: Drug-induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements. AIMS: Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide. MATERIALS & METHODS: […]
Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):30. doi: 10.1167/iovs.65.13.30. ABSTRACT PURPOSE: Localized diseases can be affected by and affect the systemic environment via blood circulation. In this study, we explored the differences in circulating serum mRNAs between patients with wet AMD (wAMD) and controls. METHODS: Blood samples were obtained from 60 Finnish patients with wAMD […]
PCSK7, a potential target for the treatment of age-related macular degeneration: inhibition of retinal epithelial cell death
Int J Clin Exp Pathol. 2024 Oct 15;17(10):371-380. doi: 10.62347/LEHU9944. eCollection 2024. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a complex disease with a pathophysiology that remains incompletely understood. PCSK7 is closely related to the normal development of ocular tissues; however, the roles and mechanisms of PCSK7 in AMD have yet to be elucidated. Therefore, […]
Multiwavelength photobiomodulation in atrophic age-related macular degeneration
Eur J Ophthalmol. 2024 Nov 15:11206721241298316. doi: 10.1177/11206721241298316. Online ahead of print. ABSTRACT PURPOSE: To evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target. METHODS: This retrospective, non-comparative case series […]
HO-1-Mediated Ferroptosis Regulates Retinal Neovascularization via the COX2/VEGFA Axis
Free Radic Biol Med. 2024 Nov 12:S0891-5849(24)01051-7. doi: 10.1016/j.freeradbiomed.2024.11.017. Online ahead of print. ABSTRACT Retinal neovascularization (RNV) is a key pathological process in many blinding disorders. This study aims to investigate the potential mechanisms of heme oxygenase-1 (HO-1) on ferroptosis during RNV. Through bioinformatics analysis, differentially expressed ferroptosis-related genes were identified in the oxygen-induced retinopathy […]
Editorial: Mitochondrial dysfunction and genetic variations in neuro-ophthalmology diseases
Front Ophthalmol (Lausanne). 2024 Oct 30;4:1483607. doi: 10.3389/fopht.2024.1483607. eCollection 2024. NO ABSTRACT PMID:39539390 | PMC:PMC11557555 | DOI:10.3389/fopht.2024.1483607
Late-Onset Mitochondrial Neurogastrointestinal Encephalopathy Presenting With Isolated Ophthalmic Findings
J Neuroophthalmol. 2024 Nov 11. doi: 10.1097/WNO.0000000000002287. Online ahead of print. NO ABSTRACT PMID:39527508 | DOI:10.1097/WNO.0000000000002287
Leber Hereditary Optic Neuropathy With Significant Visual Recovery: An MT-ND6 Mutation in a Malay Patient
Cureus. 2024 Oct 10;16(10):e71210. doi: 10.7759/cureus.71210. eCollection 2024 Oct. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare maternally inherited mitochondrial disorder that predominantly affects young men, leading to optic nerve degeneration and subsequent vision loss. The rarity of LHON and its clinical similarity to optic neuritis complicates diagnosis, necessitating genetic testing to confirm specific […]
Structure-Function Correlation in Cobalt-Induced Brain Toxicity
Cells. 2024 Oct 24;13(21):1765. doi: 10.3390/cells13211765. ABSTRACT Cobalt toxicity is difficult to detect and therefore often underdiagnosed. The aim of this study was to explore the pathophysiology of cobalt-induced oxidative stress in the brain and its impact on structure and function. Thirty-five wild-type C57B16 mice received intraperitoneal cobalt chloride injections: a single high dose with […]