Category: Ophthalmology AND mitochondrial

Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis

World J Diabetes. 2024 Jun 15;15(6):1317-1339. doi: 10.4239/wjd.v15.i6.1317. ABSTRACT BACKGROUND: Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR. AIM: To determine the HYWZF prevention mechanisms, especially those underlying mitophagy. METHODS: Human retinal capillary endothelial cells (HRCECs) were treated with high glucose […]

A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s hereditary optic neuropathy

Clin Case Rep. 2024 Jul 8;12(7):e9045. doi: 10.1002/ccr3.9045. eCollection 2024 Jul. ABSTRACT We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber’s hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion. PMID:38979087 | PMC:PMC11228619 | DOI:10.1002/ccr3.9045

Metabolomic Disparities in Intraocular Fluid Across Varied Stages of Cataract Progression: Implications for the Analysis of Cataract Development

J Ocul Pharmacol Ther. 2024 Jul 8. doi: 10.1089/jop.2024.0067. Online ahead of print. ABSTRACT Introduction: The lens’s metabolic demands are met through a continuous circulation of aqueous humor, encompassing a spectrum of components such as organic and inorganic ions, carbohydrates, glutathione, urea, amino acids, proteins, oxygen, carbon dioxide, and water. Metabolomics is a pivotal tool, […]

Thiostrepton induces oxidative stress, mitochondrial dysfunction and ferroptosis in HaCaT cells

Cell Signal. 2024 Jul 3:111285. doi: 10.1016/j.cellsig.2024.111285. Online ahead of print. ABSTRACT TST has been mainly studied for its anti-tumor proliferation and antimicrobial effects, but not widely used in dermatological diseases. The mechanism of cellular damage by TST in response to H2O2-mediated oxidative stress was investigated in human skin immortalized keratinocytes (HaCaT) as an in […]

Leber hereditary optic neuropathy in Czechia and Slovakia: Quality of life and costs from patient perspective

Heliyon. 2024 May 31;10(11):e32296. doi: 10.1016/j.heliyon.2024.e32296. eCollection 2024 Jun 15. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is the most frequent mitochondrial disease causing dyschromatopsia and progressive central visual loss that is subacute in progression and painless. Several studies have been published assessing QoL in patients with LHON, but no estimate of the economic burden […]

The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis

Cell Signal. 2024 Jul 1:111283. doi: 10.1016/j.cellsig.2024.111283. Online ahead of print. ABSTRACT It has been demonstrated that circular RNAs (circRNAs) are associated with the development of diabetic retinopathy (DR). Nevertheless, the function of circSLC16A10 in the development of DR remains unclear. In order to investigate the role of circSLC16A10, we employed cell and animal models […]

Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition

Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1. doi: 10.1167/iovs.65.8.1. ABSTRACT PURPOSE: Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible blindness. GIG is characterized by the abnormal deposition of extracellular matrix (ECM) in the trabecular meshwork (TM), elevation of intraocular pressure (IOP), and loss of retinal ganglion cells (RGCs). The […]

Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2

J Clin Invest. 2024 Jul 1;134(13):e175560. doi: 10.1172/JCI175560. ABSTRACT Mitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy […]