Organic photovoltaic biomaterial with fullerene derivatives for near-infrared light sensing in neural cells
Biointerphases. 2024 Jul 1;19(4):041001. doi: 10.1116/6.0003279. ABSTRACT Retinal degenerative diseases, which can lead to photoreceptor cell apoptosis, have now become the leading irreversible cause of blindness worldwide. In this study, we developed an organic photovoltaic biomaterial for artificial retinas, enabling neural cells to detect photoelectric stimulation. The biomaterial was prepared using a conjugated polymer donor, […]
Protocol for real-time measurement of mitochondrial respiration in the mouse ocular posterior pole using a Seahorse XFe24 analyzer
STAR Protoc. 2024 Jul 11;5(3):103150. doi: 10.1016/j.xpro.2024.103150. Online ahead of print. ABSTRACT During aging and in retinal degenerative diseases, vulnerable retinal pigment epithelial (RPE) cells are subject to mitochondrial dysfunction, creating a need for accessibility to tools which can facilitate assessment of the ocular posterior pole bioenergetics. Here, we present a protocol for quantifying mitochondrial […]
Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium
Cells. 2024 Jun 25;13(13):1100. doi: 10.3390/cells13131100. ABSTRACT The retinal pigment epithelium (RPE) is an essential component of the retina that plays multiple roles required to support visual function. These include light onset- and circadian rhythm-dependent tasks, such as daily phagocytosis of photoreceptor outer segments. Mitochondria provide energy to the highly specialized and energy-dependent RPE. In […]
Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone
Vision Res. 2024 Jul 10;222:108456. doi: 10.1016/j.visres.2024.108456. Online ahead of print. ABSTRACT Although biomechanical changes of the trabecular meshwork (TM) are important to the pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in the underlying molecular mechanisms of the development of it. In this study, we performed intravitreal triamcinolone injection (IVTA) in […]
Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
Cell Commun Signal. 2024 Jul 11;22(1):359. doi: 10.1186/s12964-024-01710-x. ABSTRACT PURPOSE: Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach available for BCD patients. Previous research has suggested that polyunsaturated fatty acids (PUFAs) may play a significant role in the development […]
A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria
Neural Regen Res. 2025 Apr 1;20(4):1081-1082. doi: 10.4103/NRR.NRR-D-24-00222. Epub 2024 Jun 3. NO ABSTRACT PMID:38989941 | DOI:10.4103/NRR.NRR-D-24-00222
Leber’s hereditary optic neuropathy: Update on current diagnosis and treatment
Front Ophthalmol (Lausanne). 2023 Jan 11;2:1077395. doi: 10.3389/fopht.2022.1077395. eCollection 2022. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a fairly prevalent mitochondrial disorder (1:50,000) arising from the dysfunction of the mitochondrial respiratory chain, which eventually leads to apoptosis of retinal ganglion cells. The usual presentation is that of a young male with a sequential reduction in […]
Flavoprotein fluorescence elevation is a marker of mitochondrial oxidative stress in patients with retinal disease
Front Ophthalmol (Lausanne). 2023 Feb 16;3:1110501. doi: 10.3389/fopht.2023.1110501. eCollection 2023. ABSTRACT PURPOSE: Recent studies of glaucoma, age-related macular degeneration, and diabetic retinopathy have demonstrated that flavoprotein fluorescence (FPF) can be utilized non-invasively as an indicator of mitochondrial oxidative stress in the retina. However, a comprehensive assessment of the validity and reliability of FPF in differentiating […]
microRNA 146a ameliorates retinal damage in experimental autoimmune uveitis
Front Ophthalmol (Lausanne). 2023 Mar 24;3:1130202. doi: 10.3389/fopht.2023.1130202. eCollection 2023. ABSTRACT INTRODUCTION: Uveitis and related intraocular inflammations are a major cause of blindness due to retinal damage caused by degeneration and loss of the photoreceptor cells. In mouse experimental autoimmune uveitis (EAU) previously we have shown mitochondrial oxidative stress with marked upregulation of αA crystallin […]
Proposing a Neurotropic Etiology for Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis
Front Ophthalmol (Lausanne). 2022 Jan 10;1:802962. doi: 10.3389/fopht.2021.802962. eCollection 2021. ABSTRACT PURPOSE: To reassess the underlying pathophysiology of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinitis (RPC) through comparison with the non-inoculated eye of the von Szily animal model of neurotropic viral retinal infection. METHODS: Narrative review. RESULTS: Literature reports of isolated […]